Highly pathogenic H5N6 avian influenza virus outbreak in Pavo cristatus in Jiangxi Province, China
ABSTRACTHighly pathogenic avian influenza (HPAI) is a persistent threat to poultry, wild birds, humans, and other mammals. The continually evolving HPAI H5N6 virus has induced great losses in breeding industries in growing regions around the world. In this study, we confirmed an outbreak of the HPAI...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1586411 |
| _version_ | 1797385802823499776 |
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| author | Meng Li Shengyong Feng Sanfu Lv Jing Luo Jianli Guo Jianhua Sun Hongxuan He |
| author_facet | Meng Li Shengyong Feng Sanfu Lv Jing Luo Jianli Guo Jianhua Sun Hongxuan He |
| author_sort | Meng Li |
| collection | DOAJ |
| description | ABSTRACTHighly pathogenic avian influenza (HPAI) is a persistent threat to poultry, wild birds, humans, and other mammals. The continually evolving HPAI H5N6 virus has induced great losses in breeding industries in growing regions around the world. In this study, we confirmed an outbreak of the HPAI H5N6 virus in captive Pavo cristatus in Jiangxi Province, China. The causative agents H5N6 viruses were isolated and designated JS01, JS02, and K10. Animal experiments showed that all three isolates exhibited high pathogenicity to chickens, but they need adaption to effectively infect mice. A phylogenetic analysis showed that all three isolates were clustered in H5 clade 2.3.4.4c. No novel genetic reassortant was found in JS01, JS02, and K10 viruses. It was estimated that JS01, JS02, and K10 H5N6 viruses were direct descendants of the H5N6 virus circulating in South of China. The estimated divergence time from tMRCAs was anywhere between May 2014 to June 2016. Although the number of outbreaks of avian influenza decreased significantly in 2018, the threat from avian influenza to public health remains serious. Enhanced active surveillance is required to monitor the transmission and evolution of H5 influenza viruses. |
| first_indexed | 2024-03-08T21:59:37Z |
| format | Article |
| id | doaj.art-e8d5616a4a9f495298e2ca9dd26b5efd |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-08T21:59:37Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-e8d5616a4a9f495298e2ca9dd26b5efd2023-12-19T16:09:57ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-018137738010.1080/22221751.2019.1586411Highly pathogenic H5N6 avian influenza virus outbreak in Pavo cristatus in Jiangxi Province, ChinaMeng Li0Shengyong Feng1Sanfu Lv2Jing Luo3Jianli Guo4Jianhua Sun5Hongxuan He6National Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, Beijing, People’s Republic of ChinaNational Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, Beijing, People’s Republic of ChinaCenter of Animal Disease Prevention and Control of Tong Zhou District, Beijing, People’s Republic of ChinaNational Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, Beijing, People’s Republic of ChinaCenter of Animal Disease Prevention and Control of Tong Zhou District, Beijing, People’s Republic of ChinaCenter of Animal Disease Prevention and Control of Tong Zhou District, Beijing, People’s Republic of ChinaNational Research Center for Wildlife Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, Beijing, People’s Republic of ChinaABSTRACTHighly pathogenic avian influenza (HPAI) is a persistent threat to poultry, wild birds, humans, and other mammals. The continually evolving HPAI H5N6 virus has induced great losses in breeding industries in growing regions around the world. In this study, we confirmed an outbreak of the HPAI H5N6 virus in captive Pavo cristatus in Jiangxi Province, China. The causative agents H5N6 viruses were isolated and designated JS01, JS02, and K10. Animal experiments showed that all three isolates exhibited high pathogenicity to chickens, but they need adaption to effectively infect mice. A phylogenetic analysis showed that all three isolates were clustered in H5 clade 2.3.4.4c. No novel genetic reassortant was found in JS01, JS02, and K10 viruses. It was estimated that JS01, JS02, and K10 H5N6 viruses were direct descendants of the H5N6 virus circulating in South of China. The estimated divergence time from tMRCAs was anywhere between May 2014 to June 2016. Although the number of outbreaks of avian influenza decreased significantly in 2018, the threat from avian influenza to public health remains serious. Enhanced active surveillance is required to monitor the transmission and evolution of H5 influenza viruses.https://www.tandfonline.com/doi/10.1080/22221751.2019.1586411Influenza virusH5N6Pavo Cristatus |
| spellingShingle | Meng Li Shengyong Feng Sanfu Lv Jing Luo Jianli Guo Jianhua Sun Hongxuan He Highly pathogenic H5N6 avian influenza virus outbreak in Pavo cristatus in Jiangxi Province, China Emerging Microbes and Infections Influenza virus H5N6 Pavo Cristatus |
| title | Highly pathogenic H5N6 avian influenza virus outbreak in Pavo cristatus in Jiangxi Province, China |
| title_full | Highly pathogenic H5N6 avian influenza virus outbreak in Pavo cristatus in Jiangxi Province, China |
| title_fullStr | Highly pathogenic H5N6 avian influenza virus outbreak in Pavo cristatus in Jiangxi Province, China |
| title_full_unstemmed | Highly pathogenic H5N6 avian influenza virus outbreak in Pavo cristatus in Jiangxi Province, China |
| title_short | Highly pathogenic H5N6 avian influenza virus outbreak in Pavo cristatus in Jiangxi Province, China |
| title_sort | highly pathogenic h5n6 avian influenza virus outbreak in pavo cristatus in jiangxi province china |
| topic | Influenza virus H5N6 Pavo Cristatus |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1586411 |
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