Engineered Lipidic Nanomaterials Inspired by Sphingomyelin Metabolism for Cancer Therapy
Sphingomyelin (SM) and its metabolites are crucial regulators of tumor cell growth, differentiation, senescence, and programmed cell death. With the rise in lipid-based nanomaterials, engineered lipidic nanomaterials inspired by SM metabolism, corresponding lipid targeting, and signaling activation...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/14/5366 |
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| author | Han Zhu Hua-Jie Chen Hai-Yan Wen Zhi-Gang Wang Shu-Lin Liu |
| author_facet | Han Zhu Hua-Jie Chen Hai-Yan Wen Zhi-Gang Wang Shu-Lin Liu |
| author_sort | Han Zhu |
| collection | DOAJ |
| description | Sphingomyelin (SM) and its metabolites are crucial regulators of tumor cell growth, differentiation, senescence, and programmed cell death. With the rise in lipid-based nanomaterials, engineered lipidic nanomaterials inspired by SM metabolism, corresponding lipid targeting, and signaling activation have made fascinating advances in cancer therapeutic processes. In this review, we first described the specific pathways of SM metabolism and the roles of their associated bioactive molecules in mediating cell survival or death. We next summarized the advantages and specific applications of SM metabolism-based lipidic nanomaterials in specific cancer therapies. Finally, we discussed the challenges and perspectives of this emerging and promising SM metabolism-based nanomaterials research area. |
| first_indexed | 2024-03-11T00:48:24Z |
| format | Article |
| id | doaj.art-e8d9f71cf1cd4dcd865ce5cc8b34d646 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:48:24Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e8d9f71cf1cd4dcd865ce5cc8b34d6462023-11-18T20:41:04ZengMDPI AGMolecules1420-30492023-07-012814536610.3390/molecules28145366Engineered Lipidic Nanomaterials Inspired by Sphingomyelin Metabolism for Cancer TherapyHan Zhu0Hua-Jie Chen1Hai-Yan Wen2Zhi-Gang Wang3Shu-Lin Liu4State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, and School of Medicine, Nankai University, Tianjin 300071, ChinaEngineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, ChinaEngineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, ChinaState Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, and School of Medicine, Nankai University, Tianjin 300071, ChinaState Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, and School of Medicine, Nankai University, Tianjin 300071, ChinaSphingomyelin (SM) and its metabolites are crucial regulators of tumor cell growth, differentiation, senescence, and programmed cell death. With the rise in lipid-based nanomaterials, engineered lipidic nanomaterials inspired by SM metabolism, corresponding lipid targeting, and signaling activation have made fascinating advances in cancer therapeutic processes. In this review, we first described the specific pathways of SM metabolism and the roles of their associated bioactive molecules in mediating cell survival or death. We next summarized the advantages and specific applications of SM metabolism-based lipidic nanomaterials in specific cancer therapies. Finally, we discussed the challenges and perspectives of this emerging and promising SM metabolism-based nanomaterials research area.https://www.mdpi.com/1420-3049/28/14/5366cancer therapylipidic nanomaterialsphingomyelin metabolismtumor progression |
| spellingShingle | Han Zhu Hua-Jie Chen Hai-Yan Wen Zhi-Gang Wang Shu-Lin Liu Engineered Lipidic Nanomaterials Inspired by Sphingomyelin Metabolism for Cancer Therapy Molecules cancer therapy lipidic nanomaterial sphingomyelin metabolism tumor progression |
| title | Engineered Lipidic Nanomaterials Inspired by Sphingomyelin Metabolism for Cancer Therapy |
| title_full | Engineered Lipidic Nanomaterials Inspired by Sphingomyelin Metabolism for Cancer Therapy |
| title_fullStr | Engineered Lipidic Nanomaterials Inspired by Sphingomyelin Metabolism for Cancer Therapy |
| title_full_unstemmed | Engineered Lipidic Nanomaterials Inspired by Sphingomyelin Metabolism for Cancer Therapy |
| title_short | Engineered Lipidic Nanomaterials Inspired by Sphingomyelin Metabolism for Cancer Therapy |
| title_sort | engineered lipidic nanomaterials inspired by sphingomyelin metabolism for cancer therapy |
| topic | cancer therapy lipidic nanomaterial sphingomyelin metabolism tumor progression |
| url | https://www.mdpi.com/1420-3049/28/14/5366 |
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