fMRI correlates of jumping-to-conclusions in patients with delusions: Connectivity patterns and effects of metacognitive training
Background: Reasoning biases such as the jumping-to-conclusions bias (JTC) are thought to contribute to delusions. Interventions targeting these biases such as metacognitive training (MCT) may improve delusions. So far, it is not clear whether JTC depends on dopaminergic reward areas that constitute...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221315821830216X |
| _version_ | 1811207453639966720 |
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| author | Christina Andreou Saskia Steinmann Gregor Leicht Katharina Kolbeck Steffen Moritz Christoph Mulert |
| author_facet | Christina Andreou Saskia Steinmann Gregor Leicht Katharina Kolbeck Steffen Moritz Christoph Mulert |
| author_sort | Christina Andreou |
| collection | DOAJ |
| description | Background: Reasoning biases such as the jumping-to-conclusions bias (JTC) are thought to contribute to delusions. Interventions targeting these biases such as metacognitive training (MCT) may improve delusions. So far, it is not clear whether JTC depends on dopaminergic reward areas that constitute the main action locus of antipsychotic drugs, or on additional cortical areas. The present study aimed to investigate fMRI activation and functional connectivity patterns underlying JTC, and their changes following MCT, in patients with delusions. Methods: Participants were 25 healthy individuals and 26 patients with current delusions who were either medication-free or on stable medication without sufficient response. We assessed (1) BOLD activity in the task-positive (TPN), task-negative (TNN), and subcortical reward network (RN); (2) Psychophysiological interactions (PPI) of peak activation areas. Results: Presence of JTC (irrespective of group) was associated with lower RN activity during conclusion events, and with increased effective connectivity between TPN and TNN during draw events. Following MCT, changes were observed in TPN activity and in effective connectivity of inferior parietal cortex (part of the TPN) with all three target networks. Conclusion: JTC is associated not only with reward system areas that constitute the main target of antipsychotic drugs, but also with cortical areas, particularly of the TPN. Keywords: Evidence gathering, Prediction error, Schizophrenia, Psychosis, Striatum |
| first_indexed | 2024-04-12T04:04:33Z |
| format | Article |
| id | doaj.art-e8dd2c787da34fcfb843078d76df754b |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-12T04:04:33Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-e8dd2c787da34fcfb843078d76df754b2022-12-22T03:48:39ZengElsevierNeuroImage: Clinical2213-15822018-01-0120119127fMRI correlates of jumping-to-conclusions in patients with delusions: Connectivity patterns and effects of metacognitive trainingChristina Andreou0Saskia Steinmann1Gregor Leicht2Katharina Kolbeck3Steffen Moritz4Christoph Mulert5Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; University Psychiatric Clinics Basel, University of Basel, Basel, Switzerland; Neuropsychology Unit, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Corresponding author. University Psychiatric Clinics Basel, Wilhelm Klein-Strasse 27, 4002 Basel, Switzerland.Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyPsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyPsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Neuropsychology Unit, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyNeuropsychology Unit, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyPsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Centre for Psychiatry and Psychotherapy, Justus-Liebig-University, Giessen, GermanyBackground: Reasoning biases such as the jumping-to-conclusions bias (JTC) are thought to contribute to delusions. Interventions targeting these biases such as metacognitive training (MCT) may improve delusions. So far, it is not clear whether JTC depends on dopaminergic reward areas that constitute the main action locus of antipsychotic drugs, or on additional cortical areas. The present study aimed to investigate fMRI activation and functional connectivity patterns underlying JTC, and their changes following MCT, in patients with delusions. Methods: Participants were 25 healthy individuals and 26 patients with current delusions who were either medication-free or on stable medication without sufficient response. We assessed (1) BOLD activity in the task-positive (TPN), task-negative (TNN), and subcortical reward network (RN); (2) Psychophysiological interactions (PPI) of peak activation areas. Results: Presence of JTC (irrespective of group) was associated with lower RN activity during conclusion events, and with increased effective connectivity between TPN and TNN during draw events. Following MCT, changes were observed in TPN activity and in effective connectivity of inferior parietal cortex (part of the TPN) with all three target networks. Conclusion: JTC is associated not only with reward system areas that constitute the main target of antipsychotic drugs, but also with cortical areas, particularly of the TPN. Keywords: Evidence gathering, Prediction error, Schizophrenia, Psychosis, Striatumhttp://www.sciencedirect.com/science/article/pii/S221315821830216X |
| spellingShingle | Christina Andreou Saskia Steinmann Gregor Leicht Katharina Kolbeck Steffen Moritz Christoph Mulert fMRI correlates of jumping-to-conclusions in patients with delusions: Connectivity patterns and effects of metacognitive training NeuroImage: Clinical |
| title | fMRI correlates of jumping-to-conclusions in patients with delusions: Connectivity patterns and effects of metacognitive training |
| title_full | fMRI correlates of jumping-to-conclusions in patients with delusions: Connectivity patterns and effects of metacognitive training |
| title_fullStr | fMRI correlates of jumping-to-conclusions in patients with delusions: Connectivity patterns and effects of metacognitive training |
| title_full_unstemmed | fMRI correlates of jumping-to-conclusions in patients with delusions: Connectivity patterns and effects of metacognitive training |
| title_short | fMRI correlates of jumping-to-conclusions in patients with delusions: Connectivity patterns and effects of metacognitive training |
| title_sort | fmri correlates of jumping to conclusions in patients with delusions connectivity patterns and effects of metacognitive training |
| url | http://www.sciencedirect.com/science/article/pii/S221315821830216X |
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