Protective role of Roflumilast against cadmium-induced cardiotoxicity through inhibition of oxidative stress and NF-κB signaling in rats

Protective role of Roflumilast against cadmium-induced cardiotoxicity through inhibition of oxidative stress and NF-κB signaling in rats

Cadmium (Cd), a potent cardiotoxic environmental heavy metal, induces oxidative stress and membrane disturbances in cardiac myocytes. Phosphodiesterase (PDEs) retards the positive inotropic effects of β-adrenoceptor activation by decreasing levels of cAMP via degradation. Hence, PDE inhibitors sensi...

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Bibliographic Details
Main Authors:	Mohd Nazam Ansari, Majid A. Ganaie, Najeeb Ur Rehman, Khalid M. Alharthy, Tajdar H. Khan, Faisal Imam, Mushtaq A. Ansari, Naif O. Al-Harbi, Basit L. Jan, Ishfaq A. Sheikh, Abubaker M. Hamad
Format:	Article
Language:	English
Published:	Elsevier 2019-07-01
Series:	Saudi Pharmaceutical Journal
Online Access:	http://www.sciencedirect.com/science/article/pii/S1319016419300520

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