A Tribute to Lewis Wolpert and His Ideas on the 50th Anniversary of the Publication of His Paper ‘Positional Information and the Spatial Pattern of Differentiation’. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis
This article is a tribute to Lewis Wolpert and his ideas on the occasion of the recent 50th anniversary of the publication of his article ‘Positional Information and the Spatial Pattern of Differentiation’. This tribute relates to another one of his ideas: his early ‘Progress Zone’ timing model for...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-04-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/7/2552 |
| _version_ | 1797571361088995328 |
|---|---|
| author | Antony J. Durston |
| author_facet | Antony J. Durston |
| author_sort | Antony J. Durston |
| collection | DOAJ |
| description | This article is a tribute to Lewis Wolpert and his ideas on the occasion of the recent 50th anniversary of the publication of his article ‘Positional Information and the Spatial Pattern of Differentiation’. This tribute relates to another one of his ideas: his early ‘Progress Zone’ timing model for limb development. Recent evidence is reviewed showing a mechanism sharing features with this model patterning the main body axis in early vertebrate development. This tribute celebrates the golden era of Developmental Biology. |
| first_indexed | 2024-03-10T20:38:16Z |
| format | Article |
| id | doaj.art-e8deb613dd7e49a7bdc8300d53876ac3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:38:16Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e8deb613dd7e49a7bdc8300d53876ac32023-11-19T20:51:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01217255210.3390/ijms21072552A Tribute to Lewis Wolpert and His Ideas on the 50th Anniversary of the Publication of His Paper ‘Positional Information and the Spatial Pattern of Differentiation’. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) AxisAntony J. Durston0Institute of Biology, University of Leiden, Sylvius Laboratory, Sylviusweg 72, 2333 BE Leiden, The NetherlandsThis article is a tribute to Lewis Wolpert and his ideas on the occasion of the recent 50th anniversary of the publication of his article ‘Positional Information and the Spatial Pattern of Differentiation’. This tribute relates to another one of his ideas: his early ‘Progress Zone’ timing model for limb development. Recent evidence is reviewed showing a mechanism sharing features with this model patterning the main body axis in early vertebrate development. This tribute celebrates the golden era of Developmental Biology.https://www.mdpi.com/1422-0067/21/7/2552hox geneslimb developmentmain body axistimingtime space translation |
| spellingShingle | Antony J. Durston A Tribute to Lewis Wolpert and His Ideas on the 50th Anniversary of the Publication of His Paper ‘Positional Information and the Spatial Pattern of Differentiation’. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis International Journal of Molecular Sciences hox genes limb development main body axis timing time space translation |
| title | A Tribute to Lewis Wolpert and His Ideas on the 50th Anniversary of the Publication of His Paper ‘Positional Information and the Spatial Pattern of Differentiation’. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis |
| title_full | A Tribute to Lewis Wolpert and His Ideas on the 50th Anniversary of the Publication of His Paper ‘Positional Information and the Spatial Pattern of Differentiation’. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis |
| title_fullStr | A Tribute to Lewis Wolpert and His Ideas on the 50th Anniversary of the Publication of His Paper ‘Positional Information and the Spatial Pattern of Differentiation’. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis |
| title_full_unstemmed | A Tribute to Lewis Wolpert and His Ideas on the 50th Anniversary of the Publication of His Paper ‘Positional Information and the Spatial Pattern of Differentiation’. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis |
| title_short | A Tribute to Lewis Wolpert and His Ideas on the 50th Anniversary of the Publication of His Paper ‘Positional Information and the Spatial Pattern of Differentiation’. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis |
| title_sort | tribute to lewis wolpert and his ideas on the 50th anniversary of the publication of his paper positional information and the spatial pattern of differentiation evidence for a timing mechanism for setting up the vertebrate anterior posterior a p axis |
| topic | hox genes limb development main body axis timing time space translation |
| url | https://www.mdpi.com/1422-0067/21/7/2552 |
| work_keys_str_mv | AT antonyjdurston atributetolewiswolpertandhisideasonthe50thanniversaryofthepublicationofhispaperpositionalinformationandthespatialpatternofdifferentiationevidenceforatimingmechanismforsettingupthevertebrateanteriorposteriorapaxis AT antonyjdurston tributetolewiswolpertandhisideasonthe50thanniversaryofthepublicationofhispaperpositionalinformationandthespatialpatternofdifferentiationevidenceforatimingmechanismforsettingupthevertebrateanteriorposteriorapaxis |