Computational and biological evaluation of N-octadecyl-N'-propylsulfamide, a selective PPARα agonist structurally related to N-acylethanolamines.

Computational and biological evaluation of N-octadecyl-N'-propylsulfamide, a selective PPARα agonist structurally related to N-acylethanolamines.

To further understand the pharmacological properties of N-oleoylethanolamine (OEA), a naturally occurring lipid that activates peroxisome proliferator-activated receptor alpha (PPARα), we designed sulfamoyl analogs based on its structure. Among the compounds tested, N-octadecyl-N'-propylsulfami...

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Bibliographic Details
Main Authors: Inmaculada Moreno-Santos, Francisco Javier Pavón, Miguel Romero-Cuevas, Antonia Serrano, Carolina Cano, Margarita Suardíaz, Juan Decara, Juan Suarez, Fernando Rodríguez de Fonseca, Manuel Macías-González
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24651609/?tool=EBI

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