The Trend of TIM3 Expression on T Cells in Patients With Nontuberculous Mycobacterial Lung Disease: From Immune Cell Dysfunction to Clinical Severity

The Trend of TIM3 Expression on T Cells in Patients With Nontuberculous Mycobacterial Lung Disease: From Immune Cell Dysfunction to Clinical Severity

BackgroundThe incidence of nontuberculous mycobacterial lung disease (NTM-LD) is increasing worldwide. Immune exhaustion has been reported in NTM-LD, but T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a co-inhibitory receptor on T cells, has been scarcely studied.MethodsPatients...

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Bibliographic Details
Main Authors: Ping-Huai Wang, Ming-Fang Wu, Chi-Yu Hsu, Sheng-Wei Pan, Chin-Chung Shu, Shih-Lung Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
apoptosis
cytokine
Mycobacterium avium complex
nontuberculous mycobacteria
lung disease
T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.738056/full

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