Association between cognitive performance and self-reported glaucoma in middle-aged and older adults: a cross-sectional analysis of ELSA-Brasil
Recent evidence suggests that glaucoma and Alzheimer's disease are neurodegenerative diseases sharing common pathophysiological and etiological features, although findings are inconclusive. We sought to investigate whether self-reported glaucoma patients without dementia present poorer cognitiv...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2020-10-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020001200608&tlng=en |
| _version_ | 1818973574480789504 |
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| author | K.S. Vidal C.K. Suemoto A.B. Moreno B. Duncan M.I. Schmidt M. Maestri S.M. Barreto P.A. Lotufo L. Bertola I.M. Bensenor A.R. Brunoni |
| author_facet | K.S. Vidal C.K. Suemoto A.B. Moreno B. Duncan M.I. Schmidt M. Maestri S.M. Barreto P.A. Lotufo L. Bertola I.M. Bensenor A.R. Brunoni |
| author_sort | K.S. Vidal |
| collection | DOAJ |
| description | Recent evidence suggests that glaucoma and Alzheimer's disease are neurodegenerative diseases sharing common pathophysiological and etiological features, although findings are inconclusive. We sought to investigate whether self-reported glaucoma patients without dementia present poorer cognitive performance, an issue that has been less investigated. We employed cross-sectional data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) and included participants ≥50 years of age without a known diagnosis of dementia and a self-reported glaucoma diagnosis. We excluded those with previous stroke, other eye conditions, and using drugs that could impair cognition. We evaluated cognition using delayed word recall, phonemic verbal fluency, and trail making (version B) tests. We used multinomial linear regression models to investigate associations between self-reported glaucoma with cognition, adjusted by several sociodemographic and clinical variables. Out of 4,331 participants, 139 reported glaucoma. Fully-adjusted models showed that self-reported glaucoma patients presented poorer performance in the verbal fluency test (β=-0.39, 95%CI=-0.64 to -0.14, P=0.002), but not in the other cognitive assessments. Thus, our results support the hypothesis that self-reported glaucoma is associated with poor cognitive performance; however, longitudinal data are necessary to corroborate our findings. |
| first_indexed | 2024-12-20T15:26:20Z |
| format | Article |
| id | doaj.art-e8e69017467841569042dbe86ba8f5c0 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-20T15:26:20Z |
| publishDate | 2020-10-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-e8e69017467841569042dbe86ba8f5c02022-12-21T19:35:49ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2020-10-01531210.1590/1414-431x202010347Association between cognitive performance and self-reported glaucoma in middle-aged and older adults: a cross-sectional analysis of ELSA-BrasilK.S. Vidalhttps://orcid.org/0000-0003-4559-2612C.K. Suemotohttps://orcid.org/0000-0002-5942-4778A.B. Morenohttps://orcid.org/0000-0002-8282-6521B. Duncanhttps://orcid.org/0000-0002-7491-2630M.I. Schmidthttps://orcid.org/0000-0002-3837-0731M. Maestrihttps://orcid.org/0000-0003-2821-5073S.M. Barretohttps://orcid.org/0000-0001-7383-7811P.A. Lotufohttps://orcid.org/0000-0002-4856-8450L. Bertolahttps://orcid.org/0000-0001-5771-2576I.M. Bensenorhttps://orcid.org/0000-0002-6723-5678A.R. Brunonihttps://orcid.org/0000-0002-6310-3571Recent evidence suggests that glaucoma and Alzheimer's disease are neurodegenerative diseases sharing common pathophysiological and etiological features, although findings are inconclusive. We sought to investigate whether self-reported glaucoma patients without dementia present poorer cognitive performance, an issue that has been less investigated. We employed cross-sectional data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) and included participants ≥50 years of age without a known diagnosis of dementia and a self-reported glaucoma diagnosis. We excluded those with previous stroke, other eye conditions, and using drugs that could impair cognition. We evaluated cognition using delayed word recall, phonemic verbal fluency, and trail making (version B) tests. We used multinomial linear regression models to investigate associations between self-reported glaucoma with cognition, adjusted by several sociodemographic and clinical variables. Out of 4,331 participants, 139 reported glaucoma. Fully-adjusted models showed that self-reported glaucoma patients presented poorer performance in the verbal fluency test (β=-0.39, 95%CI=-0.64 to -0.14, P=0.002), but not in the other cognitive assessments. Thus, our results support the hypothesis that self-reported glaucoma is associated with poor cognitive performance; however, longitudinal data are necessary to corroborate our findings.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020001200608&tlng=enCohort studyCognitive performanceGlaucomaRetinal diseasesElderly |
| spellingShingle | K.S. Vidal C.K. Suemoto A.B. Moreno B. Duncan M.I. Schmidt M. Maestri S.M. Barreto P.A. Lotufo L. Bertola I.M. Bensenor A.R. Brunoni Association between cognitive performance and self-reported glaucoma in middle-aged and older adults: a cross-sectional analysis of ELSA-Brasil Brazilian Journal of Medical and Biological Research Cohort study Cognitive performance Glaucoma Retinal diseases Elderly |
| title | Association between cognitive performance and self-reported glaucoma in middle-aged and older adults: a cross-sectional analysis of ELSA-Brasil |
| title_full | Association between cognitive performance and self-reported glaucoma in middle-aged and older adults: a cross-sectional analysis of ELSA-Brasil |
| title_fullStr | Association between cognitive performance and self-reported glaucoma in middle-aged and older adults: a cross-sectional analysis of ELSA-Brasil |
| title_full_unstemmed | Association between cognitive performance and self-reported glaucoma in middle-aged and older adults: a cross-sectional analysis of ELSA-Brasil |
| title_short | Association between cognitive performance and self-reported glaucoma in middle-aged and older adults: a cross-sectional analysis of ELSA-Brasil |
| title_sort | association between cognitive performance and self reported glaucoma in middle aged and older adults a cross sectional analysis of elsa brasil |
| topic | Cohort study Cognitive performance Glaucoma Retinal diseases Elderly |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020001200608&tlng=en |
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