Protection of Mice from Controlled Cortical Impact Injury by Food Additive Glyceryl Tribenzoate
Despite intense investigations, no effective therapy is available to halt the pathogenesis of traumatic brain injury (TBI), a major health concern, which sometimes leads to long-term neurological disability, especially in war veterans and young adults. This study highlights the use of glyceryl tribe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/2083 |
| _version_ | 1797624507082473472 |
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| author | Suresh B. Rangasamy Jit Poddar Kalipada Pahan |
| author_facet | Suresh B. Rangasamy Jit Poddar Kalipada Pahan |
| author_sort | Suresh B. Rangasamy |
| collection | DOAJ |
| description | Despite intense investigations, no effective therapy is available to halt the pathogenesis of traumatic brain injury (TBI), a major health concern, which sometimes leads to long-term neurological disability, especially in war veterans and young adults. This study highlights the use of glyceryl tribenzoate (GTB), a flavoring ingredient, in ameliorating the disease process of controlled cortical impact (CCI)-induced TBI in mice. Oral administration of GTB decreased the activation of microglia and astrocytes to inhibit the expression of inducible nitric oxide synthase (iNOS) in hippocampus and cortex of TBI mice. Accordingly, GTB treatment protected and/or restored synaptic maturation in the hippocampus of TBI mice as revealed by the status of PSD-95, NR-2A and GluR1. Furthermore, oral GTB also reduced the size of lesion cavity in the brain of TBI mice. Finally, GTB treatment improved locomotor functions and protected spatial learning and memory in TBI mice. These results outline a novel neuroprotective property of GTB which may be beneficial in treatment of TBI. |
| first_indexed | 2024-03-11T09:43:19Z |
| format | Article |
| id | doaj.art-e8e6e9261e214a2ab4dfa67241524af0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:43:19Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e8e6e9261e214a2ab4dfa67241524af02023-11-16T16:52:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243208310.3390/ijms24032083Protection of Mice from Controlled Cortical Impact Injury by Food Additive Glyceryl TribenzoateSuresh B. Rangasamy0Jit Poddar1Kalipada Pahan2Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USADepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USADivision of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USADespite intense investigations, no effective therapy is available to halt the pathogenesis of traumatic brain injury (TBI), a major health concern, which sometimes leads to long-term neurological disability, especially in war veterans and young adults. This study highlights the use of glyceryl tribenzoate (GTB), a flavoring ingredient, in ameliorating the disease process of controlled cortical impact (CCI)-induced TBI in mice. Oral administration of GTB decreased the activation of microglia and astrocytes to inhibit the expression of inducible nitric oxide synthase (iNOS) in hippocampus and cortex of TBI mice. Accordingly, GTB treatment protected and/or restored synaptic maturation in the hippocampus of TBI mice as revealed by the status of PSD-95, NR-2A and GluR1. Furthermore, oral GTB also reduced the size of lesion cavity in the brain of TBI mice. Finally, GTB treatment improved locomotor functions and protected spatial learning and memory in TBI mice. These results outline a novel neuroprotective property of GTB which may be beneficial in treatment of TBI.https://www.mdpi.com/1422-0067/24/3/2083glyceryl tribenzoateTBIglial activationlesion cavitymemory and learning |
| spellingShingle | Suresh B. Rangasamy Jit Poddar Kalipada Pahan Protection of Mice from Controlled Cortical Impact Injury by Food Additive Glyceryl Tribenzoate International Journal of Molecular Sciences glyceryl tribenzoate TBI glial activation lesion cavity memory and learning |
| title | Protection of Mice from Controlled Cortical Impact Injury by Food Additive Glyceryl Tribenzoate |
| title_full | Protection of Mice from Controlled Cortical Impact Injury by Food Additive Glyceryl Tribenzoate |
| title_fullStr | Protection of Mice from Controlled Cortical Impact Injury by Food Additive Glyceryl Tribenzoate |
| title_full_unstemmed | Protection of Mice from Controlled Cortical Impact Injury by Food Additive Glyceryl Tribenzoate |
| title_short | Protection of Mice from Controlled Cortical Impact Injury by Food Additive Glyceryl Tribenzoate |
| title_sort | protection of mice from controlled cortical impact injury by food additive glyceryl tribenzoate |
| topic | glyceryl tribenzoate TBI glial activation lesion cavity memory and learning |
| url | https://www.mdpi.com/1422-0067/24/3/2083 |
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