The Lysine Specific Demethylase-1 Negatively Regulates the <i>COL9A1</i> Gene in Human Articular Chondrocytes

The Lysine Specific Demethylase-1 Negatively Regulates the <i>COL9A1</i> Gene in Human Articular Chondrocytes

Osteoarthritis (OA) is a degenerative disease of the joints which is associated with an impaired production of the cartilage matrix by the chondrocytes. Here, we investigated the role of Lysine-Specific Demethylase-1 (LSD1), a chromatin remodeling enzyme whose role in articular chondrocytes was prev...

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Bibliographic Details
Main Authors: Anne-Laure Durand, Alexandre Dufour, Elisabeth Aubert-Foucher, Christine Oger-Desfeux, Marielle Pasdeloup, Sebastien Lustig, Elvire Servien, Gualter Vaz, Emeline Perrier-Groult, Frederic Mallein-Gerin, Jerome E. Lafont
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
articular chondrocytes
type IX collagen
lysine demethylase
osteoarthritis
Online Access:https://www.mdpi.com/1422-0067/21/17/6322

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