Regulatory T<sub>R3-56</sub> Cells in the Complex Panorama of Immune Activation and Regulation
The interplay between immune activation and immune regulation is a fundamental aspect of the functional harmony of the immune system. This delicate balance is essential to triggering correct and effective immune responses against pathogens while preventing excessive inflammation and the immunopathog...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/12/24/2841 |
| _version_ | 1797381630337220608 |
|---|---|
| author | Flavia Carriero Valentina Rubino Stefania Leone Rosangela Montanaro Vincenzo Brancaleone Giuseppina Ruggiero Giuseppe Terrazzano |
| author_facet | Flavia Carriero Valentina Rubino Stefania Leone Rosangela Montanaro Vincenzo Brancaleone Giuseppina Ruggiero Giuseppe Terrazzano |
| author_sort | Flavia Carriero |
| collection | DOAJ |
| description | The interplay between immune activation and immune regulation is a fundamental aspect of the functional harmony of the immune system. This delicate balance is essential to triggering correct and effective immune responses against pathogens while preventing excessive inflammation and the immunopathogenic mechanisms of autoimmunity. The knowledge of all the mechanisms involved in immune regulation is not yet definitive, and, probably, the overall picture is much broader than what has been described in the scientific literature so far. Given the plasticity of the immune system and the diversity of organisms, it is highly probable that numerous other cells and molecules are still to be ascribed to the immune regulation process. Here, we report a general overview of how immune activation and regulation interact, based on the involvement of molecules and cells specifically dedicated to these processes. In addition, we discuss the role of T<sub>R3-56</sub> lymphocytes as a new cellular candidate in the immune regulation landscape. |
| first_indexed | 2024-03-08T20:55:11Z |
| format | Article |
| id | doaj.art-e8e9cc3e70d14a13846f59c7c0161c80 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-08T20:55:11Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e8e9cc3e70d14a13846f59c7c0161c802023-12-22T13:59:45ZengMDPI AGCells2073-44092023-12-011224284110.3390/cells12242841Regulatory T<sub>R3-56</sub> Cells in the Complex Panorama of Immune Activation and RegulationFlavia Carriero0Valentina Rubino1Stefania Leone2Rosangela Montanaro3Vincenzo Brancaleone4Giuseppina Ruggiero5Giuseppe Terrazzano6Department of Sciences, University of Basilicata, 85100 Potenza, ItalyDepartment of Translational Medicine, University of Naples Federico II, 80131 Naples, ItalyHematopoietic Stem Cell Transplantation Unit, Azienda Ospedaliera A. Cardarelli, 80131 Naples, ItalyDepartment of Sciences, University of Basilicata, 85100 Potenza, ItalyDepartment of Sciences, University of Basilicata, 85100 Potenza, ItalyDepartment of Translational Medicine, University of Naples Federico II, 80131 Naples, ItalyDepartment of Sciences, University of Basilicata, 85100 Potenza, ItalyThe interplay between immune activation and immune regulation is a fundamental aspect of the functional harmony of the immune system. This delicate balance is essential to triggering correct and effective immune responses against pathogens while preventing excessive inflammation and the immunopathogenic mechanisms of autoimmunity. The knowledge of all the mechanisms involved in immune regulation is not yet definitive, and, probably, the overall picture is much broader than what has been described in the scientific literature so far. Given the plasticity of the immune system and the diversity of organisms, it is highly probable that numerous other cells and molecules are still to be ascribed to the immune regulation process. Here, we report a general overview of how immune activation and regulation interact, based on the involvement of molecules and cells specifically dedicated to these processes. In addition, we discuss the role of T<sub>R3-56</sub> lymphocytes as a new cellular candidate in the immune regulation landscape.https://www.mdpi.com/2073-4409/12/24/2841immune regulationimmune regulatory cell phenotypesT<sub>R3-56</sub> |
| spellingShingle | Flavia Carriero Valentina Rubino Stefania Leone Rosangela Montanaro Vincenzo Brancaleone Giuseppina Ruggiero Giuseppe Terrazzano Regulatory T<sub>R3-56</sub> Cells in the Complex Panorama of Immune Activation and Regulation Cells immune regulation immune regulatory cell phenotypes T<sub>R3-56</sub> |
| title | Regulatory T<sub>R3-56</sub> Cells in the Complex Panorama of Immune Activation and Regulation |
| title_full | Regulatory T<sub>R3-56</sub> Cells in the Complex Panorama of Immune Activation and Regulation |
| title_fullStr | Regulatory T<sub>R3-56</sub> Cells in the Complex Panorama of Immune Activation and Regulation |
| title_full_unstemmed | Regulatory T<sub>R3-56</sub> Cells in the Complex Panorama of Immune Activation and Regulation |
| title_short | Regulatory T<sub>R3-56</sub> Cells in the Complex Panorama of Immune Activation and Regulation |
| title_sort | regulatory t sub r3 56 sub cells in the complex panorama of immune activation and regulation |
| topic | immune regulation immune regulatory cell phenotypes T<sub>R3-56</sub> |
| url | https://www.mdpi.com/2073-4409/12/24/2841 |
| work_keys_str_mv | AT flaviacarriero regulatorytsubr356subcellsinthecomplexpanoramaofimmuneactivationandregulation AT valentinarubino regulatorytsubr356subcellsinthecomplexpanoramaofimmuneactivationandregulation AT stefanialeone regulatorytsubr356subcellsinthecomplexpanoramaofimmuneactivationandregulation AT rosangelamontanaro regulatorytsubr356subcellsinthecomplexpanoramaofimmuneactivationandregulation AT vincenzobrancaleone regulatorytsubr356subcellsinthecomplexpanoramaofimmuneactivationandregulation AT giuseppinaruggiero regulatorytsubr356subcellsinthecomplexpanoramaofimmuneactivationandregulation AT giuseppeterrazzano regulatorytsubr356subcellsinthecomplexpanoramaofimmuneactivationandregulation |