Conceptual Design of a Novel Nozzle Combined with a Clinical Proton Linac for Magnetically Focussed Minibeams
(1) Background: Proton minibeam radiation therapy (pMBRT) is a novel therapeutic approach with the potential to significantly increase normal tissue sparing while providing tumour control equivalent or superior to standard proton therapy. For reasons of efficiency, flexibility and minibeam quality,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/18/4657 |
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| author | Tim Schneider Annalisa Patriarca Alberto Degiovanni Manuel Gallas Yolanda Prezado |
| author_facet | Tim Schneider Annalisa Patriarca Alberto Degiovanni Manuel Gallas Yolanda Prezado |
| author_sort | Tim Schneider |
| collection | DOAJ |
| description | (1) Background: Proton minibeam radiation therapy (pMBRT) is a novel therapeutic approach with the potential to significantly increase normal tissue sparing while providing tumour control equivalent or superior to standard proton therapy. For reasons of efficiency, flexibility and minibeam quality, the optimal implementation of pMBRT should use magnetically focussed minibeams which, however, could not yet be generated in a clinical environment. In this study, we evaluated our recently proposed minibeam nozzle together with a new clinical proton linac as a potential implementation. (2) Methods: Monte Carlo simulations were performed to determine under which conditions minibeams can be generated and to evaluate the robustness against focussing magnet errors. Moreover, an example of conventional pencil beam scanning irradiation was simulated. (3) Results: Excellent minibeam sizes between 0.6 and 0.9 mm full width at half maximum could be obtained and a good tolerance to errors was observed. Furthermore, the delivery of a 10 cm × 10 cm field with pencil beams was demonstrated. (4) Conclusion: The combination of the new proton linac and minibeam nozzle could represent an optimal implementation of pMBRT by allowing the generation of magnetically focussed minibeams with clinically relevant parameters. It could furthermore be used for conventional pencil beam scanning. |
| first_indexed | 2024-03-10T07:50:46Z |
| format | Article |
| id | doaj.art-e8ea914b13b249b89ea9986ed049469a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T07:50:46Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e8ea914b13b249b89ea9986ed049469a2023-11-22T12:18:36ZengMDPI AGCancers2072-66942021-09-011318465710.3390/cancers13184657Conceptual Design of a Novel Nozzle Combined with a Clinical Proton Linac for Magnetically Focussed MinibeamsTim Schneider0Annalisa Patriarca1Alberto Degiovanni2Manuel Gallas3Yolanda Prezado4Institut Curie, Université Paris Saclay, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, 91400 Orsay, FranceCentre de Protonthérapie d’Orsay, Radiation Oncology Department, Institut Curie, PSL Research University, 91898 Orsay, FranceADAM SA, 1217 Meyrin, SwitzerlandADAM SA, 1217 Meyrin, SwitzerlandInstitut Curie, Université Paris Saclay, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, 91400 Orsay, France(1) Background: Proton minibeam radiation therapy (pMBRT) is a novel therapeutic approach with the potential to significantly increase normal tissue sparing while providing tumour control equivalent or superior to standard proton therapy. For reasons of efficiency, flexibility and minibeam quality, the optimal implementation of pMBRT should use magnetically focussed minibeams which, however, could not yet be generated in a clinical environment. In this study, we evaluated our recently proposed minibeam nozzle together with a new clinical proton linac as a potential implementation. (2) Methods: Monte Carlo simulations were performed to determine under which conditions minibeams can be generated and to evaluate the robustness against focussing magnet errors. Moreover, an example of conventional pencil beam scanning irradiation was simulated. (3) Results: Excellent minibeam sizes between 0.6 and 0.9 mm full width at half maximum could be obtained and a good tolerance to errors was observed. Furthermore, the delivery of a 10 cm × 10 cm field with pencil beams was demonstrated. (4) Conclusion: The combination of the new proton linac and minibeam nozzle could represent an optimal implementation of pMBRT by allowing the generation of magnetically focussed minibeams with clinically relevant parameters. It could furthermore be used for conventional pencil beam scanning.https://www.mdpi.com/2072-6694/13/18/4657minibeam radiation therapyprotonspMBRTlinacmagnetic focussingMonte Carlo |
| spellingShingle | Tim Schneider Annalisa Patriarca Alberto Degiovanni Manuel Gallas Yolanda Prezado Conceptual Design of a Novel Nozzle Combined with a Clinical Proton Linac for Magnetically Focussed Minibeams Cancers minibeam radiation therapy protons pMBRT linac magnetic focussing Monte Carlo |
| title | Conceptual Design of a Novel Nozzle Combined with a Clinical Proton Linac for Magnetically Focussed Minibeams |
| title_full | Conceptual Design of a Novel Nozzle Combined with a Clinical Proton Linac for Magnetically Focussed Minibeams |
| title_fullStr | Conceptual Design of a Novel Nozzle Combined with a Clinical Proton Linac for Magnetically Focussed Minibeams |
| title_full_unstemmed | Conceptual Design of a Novel Nozzle Combined with a Clinical Proton Linac for Magnetically Focussed Minibeams |
| title_short | Conceptual Design of a Novel Nozzle Combined with a Clinical Proton Linac for Magnetically Focussed Minibeams |
| title_sort | conceptual design of a novel nozzle combined with a clinical proton linac for magnetically focussed minibeams |
| topic | minibeam radiation therapy protons pMBRT linac magnetic focussing Monte Carlo |
| url | https://www.mdpi.com/2072-6694/13/18/4657 |
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