Crosstalk between apoptosis and cytotoxic lymphocytes (CTLs) in the course of Lagovirus europaeus GI.1a infection in rabbits
Lagovirus europaeus is a single-stranded RNA virus causing an acute fatal disease in wild and domestic rabbits around the world. Studies have shown that the pivotal process impacting the immune response against the disease is apoptosis, registered mainly in hepatocytes and in peripheral blood, toget...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Sciendo
2023-02-01
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| Series: | Journal of Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/jvetres-2023-0008 |
| _version_ | 1827968938550493184 |
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| author | Niedźwiedzka-Rystwej Paulina Deptuła Wiesław |
| author_facet | Niedźwiedzka-Rystwej Paulina Deptuła Wiesław |
| author_sort | Niedźwiedzka-Rystwej Paulina |
| collection | DOAJ |
| description | Lagovirus europaeus is a single-stranded RNA virus causing an acute fatal disease in wild and domestic rabbits around the world. Studies have shown that the pivotal process impacting the immune response against the disease is apoptosis, registered mainly in hepatocytes and in peripheral blood, together with an increased number of cytotoxic lymphocytes (CTLs). It is known that cytotoxic lymphocytes can induce target cells to undergo apoptosis on the pseudoreceptor pathway, such apoptosis having been found in several acute and chronic viral infections. The study aimed to assess the crosstalk between the apoptosis of peripheral blood lymphocytes and CD8+ T lymphocytes (as CTLs) in rabbits infected with 6 Lagovirus europaeus GI.1a viruses. |
| first_indexed | 2024-04-09T18:30:20Z |
| format | Article |
| id | doaj.art-e8ec375daa764ac7a454174cd16b1f07 |
| institution | Directory Open Access Journal |
| issn | 2450-8608 |
| language | English |
| last_indexed | 2024-04-09T18:30:20Z |
| publishDate | 2023-02-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Veterinary Research |
| spelling | doaj.art-e8ec375daa764ac7a454174cd16b1f072023-04-11T17:19:26ZengSciendoJournal of Veterinary Research2450-86082023-02-01671414710.2478/jvetres-2023-0008Crosstalk between apoptosis and cytotoxic lymphocytes (CTLs) in the course of Lagovirus europaeus GI.1a infection in rabbitsNiedźwiedzka-Rystwej Paulina0Deptuła Wiesław1Institute of Biology, University of Szczecin, 71-412Szczecin, PolandInstitute of Veterinary Sciences, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Toruń, 87-100Toruń, PolandLagovirus europaeus is a single-stranded RNA virus causing an acute fatal disease in wild and domestic rabbits around the world. Studies have shown that the pivotal process impacting the immune response against the disease is apoptosis, registered mainly in hepatocytes and in peripheral blood, together with an increased number of cytotoxic lymphocytes (CTLs). It is known that cytotoxic lymphocytes can induce target cells to undergo apoptosis on the pseudoreceptor pathway, such apoptosis having been found in several acute and chronic viral infections. The study aimed to assess the crosstalk between the apoptosis of peripheral blood lymphocytes and CD8+ T lymphocytes (as CTLs) in rabbits infected with 6 Lagovirus europaeus GI.1a viruses.https://doi.org/10.2478/jvetres-2023-0008lagovirus europaeusrhdvrabbitapoptosiscytotoxic lymphocytes |
| spellingShingle | Niedźwiedzka-Rystwej Paulina Deptuła Wiesław Crosstalk between apoptosis and cytotoxic lymphocytes (CTLs) in the course of Lagovirus europaeus GI.1a infection in rabbits Journal of Veterinary Research lagovirus europaeus rhdv rabbit apoptosis cytotoxic lymphocytes |
| title | Crosstalk between apoptosis and cytotoxic lymphocytes (CTLs) in the course of Lagovirus europaeus GI.1a infection in rabbits |
| title_full | Crosstalk between apoptosis and cytotoxic lymphocytes (CTLs) in the course of Lagovirus europaeus GI.1a infection in rabbits |
| title_fullStr | Crosstalk between apoptosis and cytotoxic lymphocytes (CTLs) in the course of Lagovirus europaeus GI.1a infection in rabbits |
| title_full_unstemmed | Crosstalk between apoptosis and cytotoxic lymphocytes (CTLs) in the course of Lagovirus europaeus GI.1a infection in rabbits |
| title_short | Crosstalk between apoptosis and cytotoxic lymphocytes (CTLs) in the course of Lagovirus europaeus GI.1a infection in rabbits |
| title_sort | crosstalk between apoptosis and cytotoxic lymphocytes ctls in the course of lagovirus europaeus gi 1a infection in rabbits |
| topic | lagovirus europaeus rhdv rabbit apoptosis cytotoxic lymphocytes |
| url | https://doi.org/10.2478/jvetres-2023-0008 |
| work_keys_str_mv | AT niedzwiedzkarystwejpaulina crosstalkbetweenapoptosisandcytotoxiclymphocytesctlsinthecourseoflagoviruseuropaeusgi1ainfectioninrabbits AT deptuławiesław crosstalkbetweenapoptosisandcytotoxiclymphocytesctlsinthecourseoflagoviruseuropaeusgi1ainfectioninrabbits |