Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake

Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake

Dysregulation of cholesterol homeostasis is associated with various metabolic diseases, including atherosclerosis and type 2 diabetes. The sterol response element binding protein (SREBP)-2 transcription factor induces the expression of genes involved in de novo cholesterol biosynthesis and low densi...

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Bibliographic Details
Main Authors: Muhua Yang, Weidong Liu, Christina Pellicane, Christine Sahyoun, Biny K. Joseph, Christina Gallo-Ebert, Melissa Donigan, Devanshi Pandya, Caroline Giordano, Adam Bata, Joseph T. Nickels, Jr.
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Journal of Lipid Research
Subjects:
microRNA
metabolism
cholesterol
transcription
sterol response element binding protein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520350306

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