Parietal intrahemispheric source connectivity of resting-state electroencephalographic alpha rhythms is abnormal in Naïve HIV patients
Previous evidence showed abnormal parietal sources of resting-state electroencephalographic (EEG) delta (< 4 Hz) and alpha (8–12 Hz) rhythms in treatment-Naïve HIV (Naïve HIV) subjects, as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis that these loca...
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| Language: | English |
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Elsevier
2022-04-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923022000193 |
| _version_ | 1797367860088012800 |
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| author | Claudio Babiloni Claudio Del Percio Roberta Lizio Susanna Lopez Alfredo Pennica Paolo Roma Valentina Correr Federica Cucciolla Ginevra Toma Andrea Soricelli Francesco Di Campli Antonio Aceti Elisabetta Teti Loredana Sarmati Gloria Crocetti Raffaele Ferri Ivan Lorenzo Massimo Galli Cristina Negri Gioacchino Angarano Annalisa Saracino Luciana Lepore Massimo Di Pietro Francesco Maria Fusco Vincenzo Vullo Gabriella D’Ettorre Pasquale Pagliano Giusy Di Flumeri Benedetto Maurizio Celesia Elio Gentilini Cacciola Giovanni Di Perri Andrea Calcagno Fabrizio Stocchi Stefano Ferracuti Paolo Onorati Massimo Andreoni Giuseppe Noce |
| author_facet | Claudio Babiloni Claudio Del Percio Roberta Lizio Susanna Lopez Alfredo Pennica Paolo Roma Valentina Correr Federica Cucciolla Ginevra Toma Andrea Soricelli Francesco Di Campli Antonio Aceti Elisabetta Teti Loredana Sarmati Gloria Crocetti Raffaele Ferri Ivan Lorenzo Massimo Galli Cristina Negri Gioacchino Angarano Annalisa Saracino Luciana Lepore Massimo Di Pietro Francesco Maria Fusco Vincenzo Vullo Gabriella D’Ettorre Pasquale Pagliano Giusy Di Flumeri Benedetto Maurizio Celesia Elio Gentilini Cacciola Giovanni Di Perri Andrea Calcagno Fabrizio Stocchi Stefano Ferracuti Paolo Onorati Massimo Andreoni Giuseppe Noce |
| author_sort | Claudio Babiloni |
| collection | DOAJ |
| description | Previous evidence showed abnormal parietal sources of resting-state electroencephalographic (EEG) delta (< 4 Hz) and alpha (8–12 Hz) rhythms in treatment-Naïve HIV (Naïve HIV) subjects, as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis that these local abnormalities may be related to functional cortical dysconnectivity as an oscillatory brain network disorder.The present EEG database regarded 128 Naïve HIV and 60 Healthy subjects. The eLORETA freeware estimated lagged linear EEG source connectivity (LLC). The area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification between Healthy and HIV individuals.Parietal intrahemispheric LLC solutions in alpha sources were abnormally lower in the Naïve HIV than in the control group. Furthermore, those abnormalities were greater in the Naïve HIV subgroup with executive and visuospatial deficits than the Naïve HIV subgroup with normal cognition. AUROC curves of those LLC solutions exhibited moderate/good accuracies (0.75–0.88) in the discrimination between the Naïve HIV individuals with executive and visuospatial deficits vs. Naïve HIV individuals with normal cognition and control individuals.In quiet wakefulness, Naïve HIV subjects showed clinically relevant abnormalities in parietal alpha source connectivity. HIV may alter a parietal “hub” oscillating at the alpha frequency in quiet wakefulness as a brain network disorder. |
| first_indexed | 2024-03-08T17:23:13Z |
| format | Article |
| id | doaj.art-e8ec83b2e6464988a0ad8743b044b61d |
| institution | Directory Open Access Journal |
| issn | 1873-2747 |
| language | English |
| last_indexed | 2024-03-08T17:23:13Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj.art-e8ec83b2e6464988a0ad8743b044b61d2024-01-03T04:11:11ZengElsevierBrain Research Bulletin1873-27472022-04-01181129143Parietal intrahemispheric source connectivity of resting-state electroencephalographic alpha rhythms is abnormal in Naïve HIV patientsClaudio Babiloni0Claudio Del Percio1Roberta Lizio2Susanna Lopez3Alfredo Pennica4Paolo Roma5Valentina Correr6Federica Cucciolla7Ginevra Toma8Andrea Soricelli9Francesco Di Campli10Antonio Aceti11Elisabetta Teti12Loredana Sarmati13Gloria Crocetti14Raffaele Ferri15Ivan Lorenzo16Massimo Galli17Cristina Negri18Gioacchino Angarano19Annalisa Saracino20Luciana Lepore21Massimo Di Pietro22Francesco Maria Fusco23Vincenzo Vullo24Gabriella D’Ettorre25Pasquale Pagliano26Giusy Di Flumeri27Benedetto Maurizio Celesia28Elio Gentilini Cacciola29Giovanni Di Perri30Andrea Calcagno31Fabrizio Stocchi32Stefano Ferracuti33Paolo Onorati34Massimo Andreoni35Giuseppe Noce36Department of Physiology and Pharmacology “Erspamer”, Sapienza University of Rome, Rome, Italy; Hospital San Raffaele Cassino, Cassino (FR), Italy; Correspondence to: Department of Physiology and Pharmacology ''V. Erspamer'', Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.Department of Physiology and Pharmacology “Erspamer”, Sapienza University of Rome, Rome, ItalyIRCCS Synlab SDN, Naples, ItalyDepartment of Physiology and Pharmacology “Erspamer”, Sapienza University of Rome, Rome, ItalyInfectious Diseases, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, ItalyDepartment of Human Neuroscience, Sapienza University of Rome, Rome, ItalyDepartment of Human Neuroscience, Sapienza University of Rome, Rome, ItalyDepartment of Human Neuroscience, Sapienza University of Rome, Rome, ItalyDepartment of Physiology and Pharmacology “Erspamer”, Sapienza University of Rome, Rome, ItalyIRCCS Synlab SDN, Naples, Italy; Department of Motor Sciences and Healthiness, University of Naples Parthenope, Naples, ItalyInfectious Diseases, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, ItalyInfectious Diseases, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, ItalyClinical Infectious Diseases, University of Rome “Tor Vergata”, Rome, ItalyClinical Infectious Diseases, University of Rome “Tor Vergata”, Rome, ItalyInfectious Diseases, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, ItalyOasi Research Institute - IRCCS, Troina, ItalyOasi Research Institute - IRCCS, Troina, ItalyLuigi Sacco Hospital, University of Milan, Milan, ItalyLuigi Sacco Hospital, University of Milan, Milan, ItalyClinic of Infectious Diseases, Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, ItalyClinic of Infectious Diseases, Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, ItalyClinic of Infectious Diseases, Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, ItalySanta Maria Annunziata Hospital, Florence, ItalySanta Maria Annunziata Hospital, Florence, ItalyUmberto I Hospital, Rome, ItalyUmberto I Hospital, Rome, ItalyDepartment of Medicine, Surgery and Dentistry, ''Scuola Medica Salernitana'', Unit of Infectious Diseases, University of Salerno, Baronissi, ItalyAORN dei Colli, D. Cotugno Hospital, Department of Infectious Disease and Infectious Emergencies, Naples, ItalyUnit of Infectious Diseases, Garibaldi Hospital, Catania, ItalyUmberto I Hospital, Rome, ItalyAmedeo di Savoia Hospital, Turin, ItalyUnit of Infectious Diseases, Department of Medical Sciences, University of Turin, Turin, ItalyIRCCS S. Raffaele Pisana, Rome, ItalyDepartment of Human Neuroscience, Sapienza University of Rome, Rome, ItalyDepartment of Physiology and Pharmacology “Erspamer”, Sapienza University of Rome, Rome, ItalyClinical Infectious Diseases, University of Rome “Tor Vergata”, Rome, ItalyIRCCS Synlab SDN, Naples, ItalyPrevious evidence showed abnormal parietal sources of resting-state electroencephalographic (EEG) delta (< 4 Hz) and alpha (8–12 Hz) rhythms in treatment-Naïve HIV (Naïve HIV) subjects, as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis that these local abnormalities may be related to functional cortical dysconnectivity as an oscillatory brain network disorder.The present EEG database regarded 128 Naïve HIV and 60 Healthy subjects. The eLORETA freeware estimated lagged linear EEG source connectivity (LLC). The area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification between Healthy and HIV individuals.Parietal intrahemispheric LLC solutions in alpha sources were abnormally lower in the Naïve HIV than in the control group. Furthermore, those abnormalities were greater in the Naïve HIV subgroup with executive and visuospatial deficits than the Naïve HIV subgroup with normal cognition. AUROC curves of those LLC solutions exhibited moderate/good accuracies (0.75–0.88) in the discrimination between the Naïve HIV individuals with executive and visuospatial deficits vs. Naïve HIV individuals with normal cognition and control individuals.In quiet wakefulness, Naïve HIV subjects showed clinically relevant abnormalities in parietal alpha source connectivity. HIV may alter a parietal “hub” oscillating at the alpha frequency in quiet wakefulness as a brain network disorder.http://www.sciencedirect.com/science/article/pii/S0361923022000193Human immunodeficiency virus (HIV)Functional brain connectivityResting-state EEG rhythmsExact Low-resolution brain electromagnetic source tomography (eLORETA) |
| spellingShingle | Claudio Babiloni Claudio Del Percio Roberta Lizio Susanna Lopez Alfredo Pennica Paolo Roma Valentina Correr Federica Cucciolla Ginevra Toma Andrea Soricelli Francesco Di Campli Antonio Aceti Elisabetta Teti Loredana Sarmati Gloria Crocetti Raffaele Ferri Ivan Lorenzo Massimo Galli Cristina Negri Gioacchino Angarano Annalisa Saracino Luciana Lepore Massimo Di Pietro Francesco Maria Fusco Vincenzo Vullo Gabriella D’Ettorre Pasquale Pagliano Giusy Di Flumeri Benedetto Maurizio Celesia Elio Gentilini Cacciola Giovanni Di Perri Andrea Calcagno Fabrizio Stocchi Stefano Ferracuti Paolo Onorati Massimo Andreoni Giuseppe Noce Parietal intrahemispheric source connectivity of resting-state electroencephalographic alpha rhythms is abnormal in Naïve HIV patients Brain Research Bulletin Human immunodeficiency virus (HIV) Functional brain connectivity Resting-state EEG rhythms Exact Low-resolution brain electromagnetic source tomography (eLORETA) |
| title | Parietal intrahemispheric source connectivity of resting-state electroencephalographic alpha rhythms is abnormal in Naïve HIV patients |
| title_full | Parietal intrahemispheric source connectivity of resting-state electroencephalographic alpha rhythms is abnormal in Naïve HIV patients |
| title_fullStr | Parietal intrahemispheric source connectivity of resting-state electroencephalographic alpha rhythms is abnormal in Naïve HIV patients |
| title_full_unstemmed | Parietal intrahemispheric source connectivity of resting-state electroencephalographic alpha rhythms is abnormal in Naïve HIV patients |
| title_short | Parietal intrahemispheric source connectivity of resting-state electroencephalographic alpha rhythms is abnormal in Naïve HIV patients |
| title_sort | parietal intrahemispheric source connectivity of resting state electroencephalographic alpha rhythms is abnormal in naive hiv patients |
| topic | Human immunodeficiency virus (HIV) Functional brain connectivity Resting-state EEG rhythms Exact Low-resolution brain electromagnetic source tomography (eLORETA) |
| url | http://www.sciencedirect.com/science/article/pii/S0361923022000193 |
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