Pelvic Lymph Node Dissection in Penile Cancer With Inguinal Lymph Node Extranodal Extension: A Multicenter Experience
Background: The aim of this study is to determine the necessary extent of penile lymph node dissection (PLND) in penile cancer patients with inguinal lymph node extracapsular extension (ILN-ENE).Methods: Penile cancer patients who underwent PLND in 15 centers from January 2006 to April 2020 were ret...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-06-01
|
| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2021.644273/full |
| _version_ | 1819009694851661824 |
|---|---|
| author | Zai-Shang Li Zai-Shang Li Zai-Shang Li Hui Han Hui Han Hui Han Chuang-Zhong Deng Chuang-Zhong Deng Yong-Hong Li Yong-Hong Li Yong-Hong Li Chong Wu Chong Wu Chong Wu Peng Chen Zhuo-Wei Liu Zhuo-Wei Liu Zhuo-Wei Liu Zi-Ke Qin Zi-Ke Qin Zi-Ke Qin Fang-Jian Zhou Fang-Jian Zhou Fang-Jian Zhou |
| author_facet | Zai-Shang Li Zai-Shang Li Zai-Shang Li Hui Han Hui Han Hui Han Chuang-Zhong Deng Chuang-Zhong Deng Yong-Hong Li Yong-Hong Li Yong-Hong Li Chong Wu Chong Wu Chong Wu Peng Chen Zhuo-Wei Liu Zhuo-Wei Liu Zhuo-Wei Liu Zi-Ke Qin Zi-Ke Qin Zi-Ke Qin Fang-Jian Zhou Fang-Jian Zhou Fang-Jian Zhou |
| author_sort | Zai-Shang Li |
| collection | DOAJ |
| description | Background: The aim of this study is to determine the necessary extent of penile lymph node dissection (PLND) in penile cancer patients with inguinal lymph node extracapsular extension (ILN-ENE).Methods: Penile cancer patients who underwent PLND in 15 centers from January 2006 to April 2020 were retrospectively analyzed. PLND was performed in patients with ILN-ENE.Results: Sixty-two patients with ILN-ENE were included in the analysis. A total of 51.6% (32/62) of the patients were confirmed to have pelvic lymph node metastasis (PLNM), and 31.3% (10/32) of patients were confirmed to have multiple PLNMs. Of the patients with metastases, 59.4% (19/32) had bilateral inguinal lymph node metastasis (ILNM). According to the anatomical structure, 71.9% (23/32) of the patients had PLNM in the external iliac region, and 56.2% (18/32) had PLNM in the obturator region. Among those with oligo-PLNM, 65.1% (28/43) of the patients had PLNM in the external iliac region and 38.9% (15/43) had PLNM in the obturator region. A significant overall survival difference was observed between patients with the bilateral ILNM and unilateral ILNM (36-month: 21.2 vs. 53.7%, respectively, P = 0.023). Patients with bilateral ILNM had relatively poor metastasis-free survival compared with unilateral ILNM (36-month: 33.0 vs. 13.9%, respectively, P = 0.051).Conclusions: The external iliac and obturator region were the most commonly affected regions in patients with ILN-ENE, and these regions were the only affected regions in patients with oligo-PLNM. Patients with bilateral ILNM had a high risk of PLNM and worse survival. |
| first_indexed | 2024-12-21T01:00:27Z |
| format | Article |
| id | doaj.art-e8ee9e99981f42e997b78b1e51e21eea |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-12-21T01:00:27Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-e8ee9e99981f42e997b78b1e51e21eea2022-12-21T19:21:12ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2021-06-01810.3389/fsurg.2021.644273644273Pelvic Lymph Node Dissection in Penile Cancer With Inguinal Lymph Node Extranodal Extension: A Multicenter ExperienceZai-Shang Li0Zai-Shang Li1Zai-Shang Li2Hui Han3Hui Han4Hui Han5Chuang-Zhong Deng6Chuang-Zhong Deng7Yong-Hong Li8Yong-Hong Li9Yong-Hong Li10Chong Wu11Chong Wu12Chong Wu13Peng Chen14Zhuo-Wei Liu15Zhuo-Wei Liu16Zhuo-Wei Liu17Zi-Ke Qin18Zi-Ke Qin19Zi-Ke Qin20Fang-Jian Zhou21Fang-Jian Zhou22Fang-Jian Zhou23Department of Urology, Shenzhen People's Hospital, The Second Clinic Medical College of Jinan University, Shenzhen, ChinaDepartment of Urology, First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, ChinaMinimally Invasive Urology of Shenzhen Research and Development Center of Medical Engineering and Technology, Shenzhen, ChinaDepartment of Urology, Sun Yat-sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangzhou, ChinaCollaborative Innovation Center of Cancer Medicine, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangzhou, ChinaCollaborative Innovation Center of Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangzhou, ChinaCollaborative Innovation Center of Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangzhou, ChinaCollaborative Innovation Center of Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Urology, Sun Yat-sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangzhou, ChinaCollaborative Innovation Center of Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangzhou, ChinaCollaborative Innovation Center of Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-sen University Cancer Center, Guangzhou, ChinaState Key Laboratory of Oncology in South China, Guangzhou, ChinaCollaborative Innovation Center of Cancer Medicine, Guangzhou, ChinaBackground: The aim of this study is to determine the necessary extent of penile lymph node dissection (PLND) in penile cancer patients with inguinal lymph node extracapsular extension (ILN-ENE).Methods: Penile cancer patients who underwent PLND in 15 centers from January 2006 to April 2020 were retrospectively analyzed. PLND was performed in patients with ILN-ENE.Results: Sixty-two patients with ILN-ENE were included in the analysis. A total of 51.6% (32/62) of the patients were confirmed to have pelvic lymph node metastasis (PLNM), and 31.3% (10/32) of patients were confirmed to have multiple PLNMs. Of the patients with metastases, 59.4% (19/32) had bilateral inguinal lymph node metastasis (ILNM). According to the anatomical structure, 71.9% (23/32) of the patients had PLNM in the external iliac region, and 56.2% (18/32) had PLNM in the obturator region. Among those with oligo-PLNM, 65.1% (28/43) of the patients had PLNM in the external iliac region and 38.9% (15/43) had PLNM in the obturator region. A significant overall survival difference was observed between patients with the bilateral ILNM and unilateral ILNM (36-month: 21.2 vs. 53.7%, respectively, P = 0.023). Patients with bilateral ILNM had relatively poor metastasis-free survival compared with unilateral ILNM (36-month: 33.0 vs. 13.9%, respectively, P = 0.051).Conclusions: The external iliac and obturator region were the most commonly affected regions in patients with ILN-ENE, and these regions were the only affected regions in patients with oligo-PLNM. Patients with bilateral ILNM had a high risk of PLNM and worse survival.https://www.frontiersin.org/articles/10.3389/fsurg.2021.644273/fullcancer managementmetastasissurgerysurvivalpelvic lymph node dissection |
| spellingShingle | Zai-Shang Li Zai-Shang Li Zai-Shang Li Hui Han Hui Han Hui Han Chuang-Zhong Deng Chuang-Zhong Deng Yong-Hong Li Yong-Hong Li Yong-Hong Li Chong Wu Chong Wu Chong Wu Peng Chen Zhuo-Wei Liu Zhuo-Wei Liu Zhuo-Wei Liu Zi-Ke Qin Zi-Ke Qin Zi-Ke Qin Fang-Jian Zhou Fang-Jian Zhou Fang-Jian Zhou Pelvic Lymph Node Dissection in Penile Cancer With Inguinal Lymph Node Extranodal Extension: A Multicenter Experience Frontiers in Surgery cancer management metastasis surgery survival pelvic lymph node dissection |
| title | Pelvic Lymph Node Dissection in Penile Cancer With Inguinal Lymph Node Extranodal Extension: A Multicenter Experience |
| title_full | Pelvic Lymph Node Dissection in Penile Cancer With Inguinal Lymph Node Extranodal Extension: A Multicenter Experience |
| title_fullStr | Pelvic Lymph Node Dissection in Penile Cancer With Inguinal Lymph Node Extranodal Extension: A Multicenter Experience |
| title_full_unstemmed | Pelvic Lymph Node Dissection in Penile Cancer With Inguinal Lymph Node Extranodal Extension: A Multicenter Experience |
| title_short | Pelvic Lymph Node Dissection in Penile Cancer With Inguinal Lymph Node Extranodal Extension: A Multicenter Experience |
| title_sort | pelvic lymph node dissection in penile cancer with inguinal lymph node extranodal extension a multicenter experience |
| topic | cancer management metastasis surgery survival pelvic lymph node dissection |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2021.644273/full |
| work_keys_str_mv | AT zaishangli pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT zaishangli pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT zaishangli pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT huihan pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT huihan pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT huihan pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT chuangzhongdeng pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT chuangzhongdeng pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT yonghongli pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT yonghongli pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT yonghongli pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT chongwu pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT chongwu pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT chongwu pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT pengchen pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT zhuoweiliu pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT zhuoweiliu pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT zhuoweiliu pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT zikeqin pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT zikeqin pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT zikeqin pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT fangjianzhou pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT fangjianzhou pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience AT fangjianzhou pelviclymphnodedissectioninpenilecancerwithinguinallymphnodeextranodalextensionamulticenterexperience |