Design, Preparation, Characterization and Evaluation of Five Cocrystal Hydrates of Fluconazole with Hydroxybenzoic Acids

Design, Preparation, Characterization and Evaluation of Five Cocrystal Hydrates of Fluconazole with Hydroxybenzoic Acids

To modulate the physicochemical properties of fluconazole (FLZ), a multifunctional antifungal drug, the crystal engineering technique was employed. In this paper, five novel cocrystal hydrates of FLZ with a range of phenolic acids from the GRAS list, namely, 2,4-dihydroxybenzoic acid (24DHB), 3,4-di...

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Bibliographic Details
Main Authors: Hongmei Yu, Baoxi Zhang, Meiju Liu, Wenhui Xing, Kun Hu, Shiying Yang, Guorong He, Ningbo Gong, Guanhua Du, Yang Lu
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceutics
Subjects:
fluconazole
cocrystal
hydrate
stability
dissolution
Online Access:https://www.mdpi.com/1999-4923/14/11/2486

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