Discovery and Optimization of Neutralizing SARS-CoV-2 Antibodies Using ALTHEA Gold Plus Libraries™

Discovery and Optimization of Neutralizing SARS-CoV-2 Antibodies Using ALTHEA Gold Plus Libraries™

We recently reported the isolation and characterization of anti-SARS-CoV-2 antibodies from a phage display library built with the VH repertoire of a convalescent COVID-19 patient, paired with four naïve synthetic VL libraries. One of the antibodies, called IgG-A7, neutralized the Wuhan, Delta (B.1.6...

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Bibliographic Details
Main Authors: Omar U. Guzmán-Bringas, Keyla M. Gómez-Castellano, Edith González-González, Juana Salinas-Trujano, Said Vázquez-Leyva, Luis Vallejo-Castillo, Sonia M. Pérez-Tapia, Juan C. Almagro
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
COVID-19
phage display
therapeutic antibodies
affinity maturation
semi-synthetic libraries
Online Access:https://www.mdpi.com/1422-0067/24/5/4609

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