Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays
Effective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1). Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detection...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2014-03-01
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| Series: | AIP Advances |
| Online Access: | http://dx.doi.org/10.1063/1.4869636 |
| _version_ | 1818414439819378688 |
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| author | N. Bajwa C. J. Maldonado T. Thundat A. Passian |
| author_facet | N. Bajwa C. J. Maldonado T. Thundat A. Passian |
| author_sort | N. Bajwa |
| collection | DOAJ |
| description | Effective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1). Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detection of biomolecules by transducing the antigen-antibody binding into change in resistivity via induced surface stress variation. We demonstrate a mechanical transduction of Swine H1N1 Hemagglutinin peptide binding and suggest the employed technique may offer a potential platform for detection of the H1N1 virus, which could be clinically used to diagnose and provide subsequent relief. |
| first_indexed | 2024-12-14T11:19:07Z |
| format | Article |
| id | doaj.art-e8f3f8a110a34a8c8cf5d01f961612f4 |
| institution | Directory Open Access Journal |
| issn | 2158-3226 |
| language | English |
| last_indexed | 2024-12-14T11:19:07Z |
| publishDate | 2014-03-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | AIP Advances |
| spelling | doaj.art-e8f3f8a110a34a8c8cf5d01f961612f42022-12-21T23:03:51ZengAIP Publishing LLCAIP Advances2158-32262014-03-0143037118037118-610.1063/1.4869636019403ADVPiezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arraysN. Bajwa0C. J. Maldonado1T. Thundat2A. Passian3Oak Ridge National Laboratory, Oak Ridge, TN 37831, USAClinical Investigations Facility, David Grant USAF Medical Center, Travis Air Force Base, CA 94535-1809, USADepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, T6G 2V4, CanadaOak Ridge National Laboratory, Oak Ridge, TN 37831, USAEffective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1). Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detection of biomolecules by transducing the antigen-antibody binding into change in resistivity via induced surface stress variation. We demonstrate a mechanical transduction of Swine H1N1 Hemagglutinin peptide binding and suggest the employed technique may offer a potential platform for detection of the H1N1 virus, which could be clinically used to diagnose and provide subsequent relief.http://dx.doi.org/10.1063/1.4869636 |
| spellingShingle | N. Bajwa C. J. Maldonado T. Thundat A. Passian Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays AIP Advances |
| title | Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays |
| title_full | Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays |
| title_fullStr | Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays |
| title_full_unstemmed | Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays |
| title_short | Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays |
| title_sort | piezoresistive measurement of swine h1n1 hemagglutinin peptide binding with microcantilever arrays |
| url | http://dx.doi.org/10.1063/1.4869636 |
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