4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression

4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression

Radioresistant (RR) cells are poor prognostic factors for tumor recurrence and metastasis after radiotherapy. The hyaluronan (HA) synthesis inhibitor, 4-methylumbelliferone (4-MU), shows anti-tumor and anti-metastatic effects through suppressing HA synthase (HAS) expression in various cancer cells....

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Bibliographic Details
Main Authors: Kazuki Hasegawa, Ryo Saga, Kentaro Ohuchi, Yoshikazu Kuwahara, Kazuo Tomita, Kazuhiko Okumura, Tomoaki Sato, Manabu Fukumoto, Eichi Tsuruga, Yoichiro Hosokawa
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
radioresistant cells
hyaluronan
oral squamous cell carcinoma
4-methylumbelliferone
hyaluronan synthase 3
oxidative stress
Online Access:https://www.mdpi.com/2073-4409/11/23/3780

Internet

https://www.mdpi.com/2073-4409/11/23/3780

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