The Significance of True Knot of the Umbilical Cord in Long-Term Offspring Neurological Health
We aimed to study both the short- and long-term neurological implications in offspring born with confirmed knotting of the umbilical cord—“true knot of cord”. In this population based cohort study, a comparison of perinatal outcome and long-term neurological hospitalizations was performed on the bas...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/1/123 |
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| author | Yael Lichtman Tamar Wainstock Asnat Walfisch Eyal Sheiner |
| author_facet | Yael Lichtman Tamar Wainstock Asnat Walfisch Eyal Sheiner |
| author_sort | Yael Lichtman |
| collection | DOAJ |
| description | We aimed to study both the short- and long-term neurological implications in offspring born with confirmed knotting of the umbilical cord—“true knot of cord”. In this population based cohort study, a comparison of perinatal outcome and long-term neurological hospitalizations was performed on the basis of presence or absence of true knot of cord. A Kaplan–Meier survival curve was constructed to compare the cumulative incidence of neurological hospitalizations between the study groups. Multivariable regression models were used to assess the independent association between true knot of cord, perinatal mortality and long term neurological related hospitalizations, while controlling for potential confounders. The study included 243,639 newborns, of them 1.1% (<i>n</i> = 2606) were diagnosed with true knot of the umbilical cord. Higher rates of intrauterine fetal demise (IUFD) were noted in the exposed group, a finding which remained significant in the multivariable generalized estimation equation, while controlling for confounders. The cumulative incidences of neurological hospitalizations over time were comparable between the groups. The Cox regression confirmed a lack of association between true knot of cord and total long term neurological related hospitalizations. While presence of true knot of the umbilical cord is associated with higher IUFD rates, in our population, however, its presence does not appear to impact the long term neurological health of exposed offspring. |
| first_indexed | 2024-03-10T13:35:20Z |
| format | Article |
| id | doaj.art-e8f59bd5aea74fba9e775a9166fa8660 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T13:35:20Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-e8f59bd5aea74fba9e775a9166fa86602023-11-21T07:36:00ZengMDPI AGJournal of Clinical Medicine2077-03832020-12-0110112310.3390/jcm10010123The Significance of True Knot of the Umbilical Cord in Long-Term Offspring Neurological HealthYael Lichtman0Tamar Wainstock1Asnat Walfisch2Eyal Sheiner3Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, IsraelDepartment of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, IsraelDepartment of Obstetrics and Gynecology, Hadassah Mt. Scopus Medical Center, Jerusalem 9112001, IsraelDepartment of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, IsraelWe aimed to study both the short- and long-term neurological implications in offspring born with confirmed knotting of the umbilical cord—“true knot of cord”. In this population based cohort study, a comparison of perinatal outcome and long-term neurological hospitalizations was performed on the basis of presence or absence of true knot of cord. A Kaplan–Meier survival curve was constructed to compare the cumulative incidence of neurological hospitalizations between the study groups. Multivariable regression models were used to assess the independent association between true knot of cord, perinatal mortality and long term neurological related hospitalizations, while controlling for potential confounders. The study included 243,639 newborns, of them 1.1% (<i>n</i> = 2606) were diagnosed with true knot of the umbilical cord. Higher rates of intrauterine fetal demise (IUFD) were noted in the exposed group, a finding which remained significant in the multivariable generalized estimation equation, while controlling for confounders. The cumulative incidences of neurological hospitalizations over time were comparable between the groups. The Cox regression confirmed a lack of association between true knot of cord and total long term neurological related hospitalizations. While presence of true knot of the umbilical cord is associated with higher IUFD rates, in our population, however, its presence does not appear to impact the long term neurological health of exposed offspring.https://www.mdpi.com/2077-0383/10/1/123true knot of cordperinatal outcomeslong-term neurological morbidityintrauterine hypoxia |
| spellingShingle | Yael Lichtman Tamar Wainstock Asnat Walfisch Eyal Sheiner The Significance of True Knot of the Umbilical Cord in Long-Term Offspring Neurological Health Journal of Clinical Medicine true knot of cord perinatal outcomes long-term neurological morbidity intrauterine hypoxia |
| title | The Significance of True Knot of the Umbilical Cord in Long-Term Offspring Neurological Health |
| title_full | The Significance of True Knot of the Umbilical Cord in Long-Term Offspring Neurological Health |
| title_fullStr | The Significance of True Knot of the Umbilical Cord in Long-Term Offspring Neurological Health |
| title_full_unstemmed | The Significance of True Knot of the Umbilical Cord in Long-Term Offspring Neurological Health |
| title_short | The Significance of True Knot of the Umbilical Cord in Long-Term Offspring Neurological Health |
| title_sort | significance of true knot of the umbilical cord in long term offspring neurological health |
| topic | true knot of cord perinatal outcomes long-term neurological morbidity intrauterine hypoxia |
| url | https://www.mdpi.com/2077-0383/10/1/123 |
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