Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction
The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals...
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Associação Brasileira de Divulgação Científica
2007-11-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100016 |
| _version_ | 1818914479215214592 |
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| author | R.M. Saraiva R.M. Kanashiro-Takeuchi E.L. Antonio O. Campos P.J.F. Tucci V.A. Moisés |
| author_facet | R.M. Saraiva R.M. Kanashiro-Takeuchi E.L. Antonio O. Campos P.J.F. Tucci V.A. Moisés |
| author_sort | R.M. Saraiva |
| collection | DOAJ |
| description | The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurements of LV end-diastolic pressure were made and DE was performed simultaneously 1 week after surgically induced MI (N = 16) or sham-operation (N = 17) in female Wistar rats (200 to 250 g). The ratio of peak early (E) to late (A) diastolic LV filling velocities and the ratio of E velocity to peak early (Em) diastolic myocardial velocity were the best predictors of high LV end-diastolic pressure (>12 mmHg) soon after MI. Cut-off values of 1.77 for the E/A ratio (P = 0.001) identified rats with elevated LV end-diastolic pressure with 90% sensitivity and 80% specificity. Cut-off values of 20.4 for the E/Em ratio (P = 0.0001) identified rats with elevated LV end-diastolic pressure with 81.8% sensitivity and 80% specificity. Moreover, E/A and E/Em ratios were the only echocardiographic parameters independently associated with LV end-diastolic pressure in multiple linear regression analysis. Therefore, DE identifies rats with high LV end-diastolic pressure soon after MI. These findings have implications for using serial DE in animal selection and in the assessment of their response to experimental therapies. |
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| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-19T23:47:02Z |
| publishDate | 2007-11-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-e8f5bf07a33645c2b8def32962697cc22022-12-21T20:01:16ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2007-11-0140111557156510.1590/S0100-879X2007001100016Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarctionR.M. SaraivaR.M. Kanashiro-TakeuchiE.L. AntonioO. CamposP.J.F. TucciV.A. MoisésThe severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurements of LV end-diastolic pressure were made and DE was performed simultaneously 1 week after surgically induced MI (N = 16) or sham-operation (N = 17) in female Wistar rats (200 to 250 g). The ratio of peak early (E) to late (A) diastolic LV filling velocities and the ratio of E velocity to peak early (Em) diastolic myocardial velocity were the best predictors of high LV end-diastolic pressure (>12 mmHg) soon after MI. Cut-off values of 1.77 for the E/A ratio (P = 0.001) identified rats with elevated LV end-diastolic pressure with 90% sensitivity and 80% specificity. Cut-off values of 20.4 for the E/Em ratio (P = 0.0001) identified rats with elevated LV end-diastolic pressure with 81.8% sensitivity and 80% specificity. Moreover, E/A and E/Em ratios were the only echocardiographic parameters independently associated with LV end-diastolic pressure in multiple linear regression analysis. Therefore, DE identifies rats with high LV end-diastolic pressure soon after MI. These findings have implications for using serial DE in animal selection and in the assessment of their response to experimental therapies.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100016Heart failureMyocardial infarctionEchocardiographyHemodynamics |
| spellingShingle | R.M. Saraiva R.M. Kanashiro-Takeuchi E.L. Antonio O. Campos P.J.F. Tucci V.A. Moisés Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction Brazilian Journal of Medical and Biological Research Heart failure Myocardial infarction Echocardiography Hemodynamics |
| title | Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction |
| title_full | Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction |
| title_fullStr | Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction |
| title_full_unstemmed | Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction |
| title_short | Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction |
| title_sort | rats with high left ventricular end diastolic pressure can be identified by doppler echocardiography one week after myocardial infarction |
| topic | Heart failure Myocardial infarction Echocardiography Hemodynamics |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100016 |
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