Chorion-derived perinatal mesenchymal stem cells improve cardiac function and vascular regeneration: Preferential treatment for ischemic heart disease
Background: Stem cell therapy has emerged as a novel treatment for heart failure after myocardial infarction (Ml). Bone marrow-derived mesenchymal stem cells (BM-MSCs) are commonly considered because of their accessibility and usability. However, their therapeutic potential remains controversial. In...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Hellenic Journal of Cardiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1109966622000872 |
| _version_ | 1818499288765825024 |
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| author | Yong Soo Park Bong-Woo Park Hayoung Choi Seung Hee Lee Myungshin Kim Hun-Jun Park In-Beom Kim |
| author_facet | Yong Soo Park Bong-Woo Park Hayoung Choi Seung Hee Lee Myungshin Kim Hun-Jun Park In-Beom Kim |
| author_sort | Yong Soo Park |
| collection | DOAJ |
| description | Background: Stem cell therapy has emerged as a novel treatment for heart failure after myocardial infarction (Ml). Bone marrow-derived mesenchymal stem cells (BM-MSCs) are commonly considered because of their accessibility and usability. However, their therapeutic potential remains controversial. In our previous in vitro study, chorion-derived mesenchymal stem cells (C-MSCs) and umbilical cord-derived mesenchymal stem cells (UC-MSCs) demonstrated an ability to differentiate into cardiomyocytes and neural cells, respectively. Thus, we examined whether C-MSCs had a better differentiation potential in an MI animal model. Methods: MI was induced by ligation of the left anterior descending artery, and DiI-labeled MSCs were injected into the border of the infarcted myocardium. The left ventricular ejection fraction (LVEF) and fractional shortening (FS) were measured using echocardiograms. Masson's Trichrome staining was performed to evaluate the viable myocardium. Alpha-sarcomeric actin (α-SA), cardiac troponin-T (cTnT), and isolectin were immunolabeled to evaluate differentiation and capillary formation. Results: After 8 weeks, the LVEF and FS significantly increased to a greater extent in the C-MSC-injected group with maintenance of viable myocardium, as compared to in the control, UC-MSC-, and BM-MSC-injected groups (p < 0.05). Compared to UC-MSCs and BM-MSCs, C-MSCs significantly increased the capillary density (p < 0.05) and demonstrated higher expressions of cTnT and α-SA. Conclusions: In conclusion, compared to UC-MSCs and BM-MSCs, C-MSCs showed a better therapeutic efficacy in a rat MI model. |
| first_indexed | 2024-12-10T20:27:22Z |
| format | Article |
| id | doaj.art-e8f7d776836f4b3192baf2b40f08f312 |
| institution | Directory Open Access Journal |
| issn | 1109-9666 |
| language | English |
| last_indexed | 2024-12-10T20:27:22Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hellenic Journal of Cardiology |
| spelling | doaj.art-e8f7d776836f4b3192baf2b40f08f3122022-12-22T01:34:50ZengElsevierHellenic Journal of Cardiology1109-96662022-07-01665258Chorion-derived perinatal mesenchymal stem cells improve cardiac function and vascular regeneration: Preferential treatment for ischemic heart diseaseYong Soo Park0Bong-Woo Park1Hayoung Choi2Seung Hee Lee3Myungshin Kim4Hun-Jun Park5In-Beom Kim6Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Medical Life Science, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, KoreaCatholic Genetic Laboratory Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaCatholic Genetic Laboratory Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Medical Life Science, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Catholic Institute for Applied Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Corresponding author. Department of Anatomy, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Korea Tel.: +82-2-2258-7263; Fax: +82-2-536-3110.Background: Stem cell therapy has emerged as a novel treatment for heart failure after myocardial infarction (Ml). Bone marrow-derived mesenchymal stem cells (BM-MSCs) are commonly considered because of their accessibility and usability. However, their therapeutic potential remains controversial. In our previous in vitro study, chorion-derived mesenchymal stem cells (C-MSCs) and umbilical cord-derived mesenchymal stem cells (UC-MSCs) demonstrated an ability to differentiate into cardiomyocytes and neural cells, respectively. Thus, we examined whether C-MSCs had a better differentiation potential in an MI animal model. Methods: MI was induced by ligation of the left anterior descending artery, and DiI-labeled MSCs were injected into the border of the infarcted myocardium. The left ventricular ejection fraction (LVEF) and fractional shortening (FS) were measured using echocardiograms. Masson's Trichrome staining was performed to evaluate the viable myocardium. Alpha-sarcomeric actin (α-SA), cardiac troponin-T (cTnT), and isolectin were immunolabeled to evaluate differentiation and capillary formation. Results: After 8 weeks, the LVEF and FS significantly increased to a greater extent in the C-MSC-injected group with maintenance of viable myocardium, as compared to in the control, UC-MSC-, and BM-MSC-injected groups (p < 0.05). Compared to UC-MSCs and BM-MSCs, C-MSCs significantly increased the capillary density (p < 0.05) and demonstrated higher expressions of cTnT and α-SA. Conclusions: In conclusion, compared to UC-MSCs and BM-MSCs, C-MSCs showed a better therapeutic efficacy in a rat MI model.http://www.sciencedirect.com/science/article/pii/S1109966622000872Perinatal mesenchymal stem cellmyocardial infarction (Ml)differentiationcardiac markersangiogenesis |
| spellingShingle | Yong Soo Park Bong-Woo Park Hayoung Choi Seung Hee Lee Myungshin Kim Hun-Jun Park In-Beom Kim Chorion-derived perinatal mesenchymal stem cells improve cardiac function and vascular regeneration: Preferential treatment for ischemic heart disease Hellenic Journal of Cardiology Perinatal mesenchymal stem cell myocardial infarction (Ml) differentiation cardiac markers angiogenesis |
| title | Chorion-derived perinatal mesenchymal stem cells improve cardiac function and vascular regeneration: Preferential treatment for ischemic heart disease |
| title_full | Chorion-derived perinatal mesenchymal stem cells improve cardiac function and vascular regeneration: Preferential treatment for ischemic heart disease |
| title_fullStr | Chorion-derived perinatal mesenchymal stem cells improve cardiac function and vascular regeneration: Preferential treatment for ischemic heart disease |
| title_full_unstemmed | Chorion-derived perinatal mesenchymal stem cells improve cardiac function and vascular regeneration: Preferential treatment for ischemic heart disease |
| title_short | Chorion-derived perinatal mesenchymal stem cells improve cardiac function and vascular regeneration: Preferential treatment for ischemic heart disease |
| title_sort | chorion derived perinatal mesenchymal stem cells improve cardiac function and vascular regeneration preferential treatment for ischemic heart disease |
| topic | Perinatal mesenchymal stem cell myocardial infarction (Ml) differentiation cardiac markers angiogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S1109966622000872 |
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