A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis
The Polycomb Repressive Complex 2 (PRC2) methylates H3K27 to regulate development and cell fate by transcriptional silencing. Alteration of PRC2 is associated with various cancers. Here, we show that mouse Kdm1a deletion causes a dramatic reduction of PRC2 proteins, whereas mouse null mutation of L3...
Main Authors: | Pengfei Guo, Rebecca C Lim, Keshari Rajawasam, Tiffany Trinh, Hong Sun, Hui Zhang |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2024-02-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/86168 |
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