Epidemiological, Clinical and Laboratory Features of Strongyloidiasis in 69 Attendees at a French Outpatient Clinic
The present retrospective study analyzed the characteristics of strongyloidiasis in patients who were diagnosed at the Outpatient Clinic of the Department of Parasitology-Mycology, Toulouse, France. Sixty-nine file records were included in the study on the basis of a positive stool examination that...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/12/8/983 |
| _version_ | 1797583593037365248 |
|---|---|
| author | Jean-François Magnaval Judith Fillaux Richard Fabre Sophie Cassaing Alexis Valentin Xavier Iriart Antoine Berry |
| author_facet | Jean-François Magnaval Judith Fillaux Richard Fabre Sophie Cassaing Alexis Valentin Xavier Iriart Antoine Berry |
| author_sort | Jean-François Magnaval |
| collection | DOAJ |
| description | The present retrospective study analyzed the characteristics of strongyloidiasis in patients who were diagnosed at the Outpatient Clinic of the Department of Parasitology-Mycology, Toulouse, France. Sixty-nine file records were included in the study on the basis of a positive stool examination that used Baermann’s method. The prominent epidemiological findings were the presence of former immigrants from Italy or Portugal, veterans from the 1st Indochina war, and autochthonous cases. Almost 1/4 of the patients were asymptomatic. Manifestations of skin allergy were the main clinical feature. Blood eosinophilia was present in 76.8% of the patients, and serum total IgE was ≥150 kIU/L in 79.7%. Immunodiagnosis was achieved from 1990 to 2001 by indirect immunofluorescence (IFAT) that was then replaced with ELISA, both methods using <i>Strongyloides ratti</i> filariform larvae. ELISA was found to be similar to IFAT in terms of specificity but exhibited a greater sensitivity. Patients were primarily treated with albendazole or ivermectin beginning in 1993. Forty-eight patients attended the follow-up consultation. Kinetics of the clinical picture and blood eosinophilia were found to be the most convenient parameters to assess the efficacy of anthelmintic therapy. In conclusion, strongyloidiasis remains a neglected disease in Southwestern France. The resolution of clinical features along with the kinetics of eosinophilia appeared to be the most appropriate parameters to check during the posttreatment follow-up. |
| first_indexed | 2024-03-10T23:41:00Z |
| format | Article |
| id | doaj.art-e8f8a45eab7b49749779cb16a2655bda |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T23:41:00Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-e8f8a45eab7b49749779cb16a2655bda2023-11-19T02:31:44ZengMDPI AGPathogens2076-08172023-07-0112898310.3390/pathogens12080983Epidemiological, Clinical and Laboratory Features of Strongyloidiasis in 69 Attendees at a French Outpatient ClinicJean-François Magnaval0Judith Fillaux1Richard Fabre2Sophie Cassaing3Alexis Valentin4Xavier Iriart5Antoine Berry6Service de Parasitologie Médicale, Faculté de Médecine, Université de Toulouse, 31000 Toulouse, FranceService de Parasitologie-Mycologie, Hôpital Purpan, Centre Hospitalier Universitaire de Toulouse, TSA 4003, 31059 Toulouse, FranceDENDRIS, 335 Rue du Chêne Vert, 31670 Labège, FranceService de Parasitologie-Mycologie, Hôpital Purpan, Centre Hospitalier Universitaire de Toulouse, TSA 4003, 31059 Toulouse, FranceService de Parasitologie-Mycologie, Hôpital Purpan, Centre Hospitalier Universitaire de Toulouse, TSA 4003, 31059 Toulouse, FranceService de Parasitologie-Mycologie, Hôpital Purpan, Centre Hospitalier Universitaire de Toulouse, TSA 4003, 31059 Toulouse, FranceService de Parasitologie-Mycologie, Hôpital Purpan, Centre Hospitalier Universitaire de Toulouse, TSA 4003, 31059 Toulouse, FranceThe present retrospective study analyzed the characteristics of strongyloidiasis in patients who were diagnosed at the Outpatient Clinic of the Department of Parasitology-Mycology, Toulouse, France. Sixty-nine file records were included in the study on the basis of a positive stool examination that used Baermann’s method. The prominent epidemiological findings were the presence of former immigrants from Italy or Portugal, veterans from the 1st Indochina war, and autochthonous cases. Almost 1/4 of the patients were asymptomatic. Manifestations of skin allergy were the main clinical feature. Blood eosinophilia was present in 76.8% of the patients, and serum total IgE was ≥150 kIU/L in 79.7%. Immunodiagnosis was achieved from 1990 to 2001 by indirect immunofluorescence (IFAT) that was then replaced with ELISA, both methods using <i>Strongyloides ratti</i> filariform larvae. ELISA was found to be similar to IFAT in terms of specificity but exhibited a greater sensitivity. Patients were primarily treated with albendazole or ivermectin beginning in 1993. Forty-eight patients attended the follow-up consultation. Kinetics of the clinical picture and blood eosinophilia were found to be the most convenient parameters to assess the efficacy of anthelmintic therapy. In conclusion, strongyloidiasis remains a neglected disease in Southwestern France. The resolution of clinical features along with the kinetics of eosinophilia appeared to be the most appropriate parameters to check during the posttreatment follow-up.https://www.mdpi.com/2076-0817/12/8/983strongyloidiasissouthwestern Franceepidemiologyclinical pictureeosinophilia<i>Strongyloides ratti</i> |
| spellingShingle | Jean-François Magnaval Judith Fillaux Richard Fabre Sophie Cassaing Alexis Valentin Xavier Iriart Antoine Berry Epidemiological, Clinical and Laboratory Features of Strongyloidiasis in 69 Attendees at a French Outpatient Clinic Pathogens strongyloidiasis southwestern France epidemiology clinical picture eosinophilia <i>Strongyloides ratti</i> |
| title | Epidemiological, Clinical and Laboratory Features of Strongyloidiasis in 69 Attendees at a French Outpatient Clinic |
| title_full | Epidemiological, Clinical and Laboratory Features of Strongyloidiasis in 69 Attendees at a French Outpatient Clinic |
| title_fullStr | Epidemiological, Clinical and Laboratory Features of Strongyloidiasis in 69 Attendees at a French Outpatient Clinic |
| title_full_unstemmed | Epidemiological, Clinical and Laboratory Features of Strongyloidiasis in 69 Attendees at a French Outpatient Clinic |
| title_short | Epidemiological, Clinical and Laboratory Features of Strongyloidiasis in 69 Attendees at a French Outpatient Clinic |
| title_sort | epidemiological clinical and laboratory features of strongyloidiasis in 69 attendees at a french outpatient clinic |
| topic | strongyloidiasis southwestern France epidemiology clinical picture eosinophilia <i>Strongyloides ratti</i> |
| url | https://www.mdpi.com/2076-0817/12/8/983 |
| work_keys_str_mv | AT jeanfrancoismagnaval epidemiologicalclinicalandlaboratoryfeaturesofstrongyloidiasisin69attendeesatafrenchoutpatientclinic AT judithfillaux epidemiologicalclinicalandlaboratoryfeaturesofstrongyloidiasisin69attendeesatafrenchoutpatientclinic AT richardfabre epidemiologicalclinicalandlaboratoryfeaturesofstrongyloidiasisin69attendeesatafrenchoutpatientclinic AT sophiecassaing epidemiologicalclinicalandlaboratoryfeaturesofstrongyloidiasisin69attendeesatafrenchoutpatientclinic AT alexisvalentin epidemiologicalclinicalandlaboratoryfeaturesofstrongyloidiasisin69attendeesatafrenchoutpatientclinic AT xavieririart epidemiologicalclinicalandlaboratoryfeaturesofstrongyloidiasisin69attendeesatafrenchoutpatientclinic AT antoineberry epidemiologicalclinicalandlaboratoryfeaturesofstrongyloidiasisin69attendeesatafrenchoutpatientclinic |