Incidence of post-transplant glomerulonephritis and its impact on graft outcome
Background: Herein, the significance of post-transplant glomerulonephritis (PTGN) has been revisited to investigate whether PTGN induces allograft failure. The aim of this study was to identify the incidence of PTGN and its association with allograft failure, as well as to analyze the risk factors f...
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2012-12-01
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| Series: | Kidney Research and Clinical Practice |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211913212007395 |
| _version_ | 1818109898735484928 |
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| author | Jung Nam An Jung Pyo Lee Yun Jung Oh Yun Kyu Oh Jong-won Ha Dong-Wan Chae Yon Su Kim Chun Soo Lim |
| author_facet | Jung Nam An Jung Pyo Lee Yun Jung Oh Yun Kyu Oh Jong-won Ha Dong-Wan Chae Yon Su Kim Chun Soo Lim |
| author_sort | Jung Nam An |
| collection | DOAJ |
| description | Background: Herein, the significance of post-transplant glomerulonephritis (PTGN) has been revisited to investigate whether PTGN induces allograft failure. The aim of this study was to identify the incidence of PTGN and its association with allograft failure, as well as to analyze the risk factors for PTGN.
Methods: Among the 996 Korean patients who underwent kidney transplantation in a multicenter cohort from 1995 to 2010, 764 patients were enrolled in this study.
Results: The incidence rate of PTGN was 9.7% and 17.0% at 5 and 10 years of follow-up, respectively. PTGN was diagnosed in 17.8% of the recipients with results of biopsy tests or clinical diagnosis identifying glomerular diseases as the underlying cause, compared with 0.0%, 4.4%, 4.9%, 5.5%, and 5.7% of the recipients with renal vascular diseases, renal interstitial diseases/pyelonephritis/uropathy, diabetic renal disease, hereditary renal diseases, and diseases with unknown etiologies, respectively. Allograft survival was significantly decreased in patients with PTGN. PTGN was associated with a fourfold increase in graft failure with a hazard ratio of 7.11 for both acute rejection and PTGN. Results of the risk factor analysis for PTGN revealed that the underlying glomerular renal diseases and treatment methods using drugs such as tacrolimus and basiliximab significantly increased PTGN development, after adjusting for other risk factors.
Conclusion: We conclude that PTGN is strongly associated with poor kidney allograft survival. Therefore, optimal management of recurrent or de novo GN should be the critical focus of post-transplant care. |
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| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-11T02:38:34Z |
| publishDate | 2012-12-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-e8f9058b4d104a84a9c28f5ba89ff89d2022-12-22T01:23:40ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322012-12-0131421922610.1016/j.krcp.2012.09.004Incidence of post-transplant glomerulonephritis and its impact on graft outcomeJung Nam An0Jung Pyo Lee1Yun Jung Oh2Yun Kyu Oh3Jong-won Ha4Dong-Wan Chae5Yon Su Kim6Chun Soo Lim7Department of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaDepartment of Surgery, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaBackground: Herein, the significance of post-transplant glomerulonephritis (PTGN) has been revisited to investigate whether PTGN induces allograft failure. The aim of this study was to identify the incidence of PTGN and its association with allograft failure, as well as to analyze the risk factors for PTGN. Methods: Among the 996 Korean patients who underwent kidney transplantation in a multicenter cohort from 1995 to 2010, 764 patients were enrolled in this study. Results: The incidence rate of PTGN was 9.7% and 17.0% at 5 and 10 years of follow-up, respectively. PTGN was diagnosed in 17.8% of the recipients with results of biopsy tests or clinical diagnosis identifying glomerular diseases as the underlying cause, compared with 0.0%, 4.4%, 4.9%, 5.5%, and 5.7% of the recipients with renal vascular diseases, renal interstitial diseases/pyelonephritis/uropathy, diabetic renal disease, hereditary renal diseases, and diseases with unknown etiologies, respectively. Allograft survival was significantly decreased in patients with PTGN. PTGN was associated with a fourfold increase in graft failure with a hazard ratio of 7.11 for both acute rejection and PTGN. Results of the risk factor analysis for PTGN revealed that the underlying glomerular renal diseases and treatment methods using drugs such as tacrolimus and basiliximab significantly increased PTGN development, after adjusting for other risk factors. Conclusion: We conclude that PTGN is strongly associated with poor kidney allograft survival. Therefore, optimal management of recurrent or de novo GN should be the critical focus of post-transplant care.http://www.sciencedirect.com/science/article/pii/S2211913212007395GlomerulonephritisGraft survivalKidney transplantationRisk factors |
| spellingShingle | Jung Nam An Jung Pyo Lee Yun Jung Oh Yun Kyu Oh Jong-won Ha Dong-Wan Chae Yon Su Kim Chun Soo Lim Incidence of post-transplant glomerulonephritis and its impact on graft outcome Kidney Research and Clinical Practice Glomerulonephritis Graft survival Kidney transplantation Risk factors |
| title | Incidence of post-transplant glomerulonephritis and its impact on graft outcome |
| title_full | Incidence of post-transplant glomerulonephritis and its impact on graft outcome |
| title_fullStr | Incidence of post-transplant glomerulonephritis and its impact on graft outcome |
| title_full_unstemmed | Incidence of post-transplant glomerulonephritis and its impact on graft outcome |
| title_short | Incidence of post-transplant glomerulonephritis and its impact on graft outcome |
| title_sort | incidence of post transplant glomerulonephritis and its impact on graft outcome |
| topic | Glomerulonephritis Graft survival Kidney transplantation Risk factors |
| url | http://www.sciencedirect.com/science/article/pii/S2211913212007395 |
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