The Impact of Music on Stress Biomarkers: Protocol of a Substudy of the Cluster-Randomized Controlled Trial Music Interventions for Dementia and Depression in ELderly Care (MIDDEL)
Recently, a large cluster-randomized controlled trial was designed—Music Interventions for Dementia and Depression in ELderly care (MIDDEL)—to assess the effectiveness of music interventions on depression in care home residents with dementia (ClinicalTrials.gov NCT03496675). To understand the pathop...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/4/485 |
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| author | Naomi L. Rasing Sarah I. M. Janus Gunter Kreutz Vigdis Sveinsdottir Christian Gold Urs M. Nater Sytse U. Zuidema |
| author_facet | Naomi L. Rasing Sarah I. M. Janus Gunter Kreutz Vigdis Sveinsdottir Christian Gold Urs M. Nater Sytse U. Zuidema |
| author_sort | Naomi L. Rasing |
| collection | DOAJ |
| description | Recently, a large cluster-randomized controlled trial was designed—Music Interventions for Dementia and Depression in ELderly care (MIDDEL)—to assess the effectiveness of music interventions on depression in care home residents with dementia (ClinicalTrials.gov NCT03496675). To understand the pathophysiological mechanisms, we observed the effect of repeated music interventions on stress in this population since chronic stress was associated with depression and an increased risk for dementia. An exploratory study was designed to assess: (1) changes in hair cortisol concentrations as an indicator of longer-term stress; (2) whether baseline stress is a predictor of therapy outcome; (3) pre- and post-treatment effects on salivary α-amylase and cortisol response as an indicator of immediate stress in 180–200 care home residents with dementia and depressive symptoms who partake in the MIDDEL trial. Insights into mediatory effects of stress to explain the effect of music interventions will be gained. Hair cortisol concentrations were assessed at baseline and at 3, 6, and 12 months along with the Perceived Stress Scale. Salivary α-amylase and cortisol concentrations were assessed at 1, 3, and 6 months. Saliva was collected just before a session and 15 and 60 min after a session, along with a stress Visual Analogue Scale. |
| first_indexed | 2024-03-09T11:05:38Z |
| format | Article |
| id | doaj.art-e8fb88fb7908433f9a014c5006a6ec85 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T11:05:38Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-e8fb88fb7908433f9a014c5006a6ec852023-12-01T00:59:59ZengMDPI AGBrain Sciences2076-34252022-04-0112448510.3390/brainsci12040485The Impact of Music on Stress Biomarkers: Protocol of a Substudy of the Cluster-Randomized Controlled Trial Music Interventions for Dementia and Depression in ELderly Care (MIDDEL)Naomi L. Rasing0Sarah I. M. Janus1Gunter Kreutz2Vigdis Sveinsdottir3Christian Gold4Urs M. Nater5Sytse U. Zuidema6Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, 9700 AD Groningen, The NetherlandsDepartment of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, 9700 AD Groningen, The NetherlandsDepartment of Music, Speech and Music Lab, Carl von Ossietzky University Oldenburg, Ammerländer Heerstraße 114-118, 26129 Oldenburg, GermanyNORCE Norwegian Research Centre AS, Nygårdsgaten 112, 5008 Bergen, NorwayNORCE Norwegian Research Centre AS, Nygårdsgaten 112, 5008 Bergen, NorwayDepartment of Clinical and Health Psychology, University of Vienna, Liebiggasse 5, 1010 Vienna, AustriaDepartment of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, 9700 AD Groningen, The NetherlandsRecently, a large cluster-randomized controlled trial was designed—Music Interventions for Dementia and Depression in ELderly care (MIDDEL)—to assess the effectiveness of music interventions on depression in care home residents with dementia (ClinicalTrials.gov NCT03496675). To understand the pathophysiological mechanisms, we observed the effect of repeated music interventions on stress in this population since chronic stress was associated with depression and an increased risk for dementia. An exploratory study was designed to assess: (1) changes in hair cortisol concentrations as an indicator of longer-term stress; (2) whether baseline stress is a predictor of therapy outcome; (3) pre- and post-treatment effects on salivary α-amylase and cortisol response as an indicator of immediate stress in 180–200 care home residents with dementia and depressive symptoms who partake in the MIDDEL trial. Insights into mediatory effects of stress to explain the effect of music interventions will be gained. Hair cortisol concentrations were assessed at baseline and at 3, 6, and 12 months along with the Perceived Stress Scale. Salivary α-amylase and cortisol concentrations were assessed at 1, 3, and 6 months. Saliva was collected just before a session and 15 and 60 min after a session, along with a stress Visual Analogue Scale.https://www.mdpi.com/2076-3425/12/4/485alpha-amylasecortisolmusic therapymusic-based therapies and interventionssalivahair |
| spellingShingle | Naomi L. Rasing Sarah I. M. Janus Gunter Kreutz Vigdis Sveinsdottir Christian Gold Urs M. Nater Sytse U. Zuidema The Impact of Music on Stress Biomarkers: Protocol of a Substudy of the Cluster-Randomized Controlled Trial Music Interventions for Dementia and Depression in ELderly Care (MIDDEL) Brain Sciences alpha-amylase cortisol music therapy music-based therapies and interventions saliva hair |
| title | The Impact of Music on Stress Biomarkers: Protocol of a Substudy of the Cluster-Randomized Controlled Trial Music Interventions for Dementia and Depression in ELderly Care (MIDDEL) |
| title_full | The Impact of Music on Stress Biomarkers: Protocol of a Substudy of the Cluster-Randomized Controlled Trial Music Interventions for Dementia and Depression in ELderly Care (MIDDEL) |
| title_fullStr | The Impact of Music on Stress Biomarkers: Protocol of a Substudy of the Cluster-Randomized Controlled Trial Music Interventions for Dementia and Depression in ELderly Care (MIDDEL) |
| title_full_unstemmed | The Impact of Music on Stress Biomarkers: Protocol of a Substudy of the Cluster-Randomized Controlled Trial Music Interventions for Dementia and Depression in ELderly Care (MIDDEL) |
| title_short | The Impact of Music on Stress Biomarkers: Protocol of a Substudy of the Cluster-Randomized Controlled Trial Music Interventions for Dementia and Depression in ELderly Care (MIDDEL) |
| title_sort | impact of music on stress biomarkers protocol of a substudy of the cluster randomized controlled trial music interventions for dementia and depression in elderly care middel |
| topic | alpha-amylase cortisol music therapy music-based therapies and interventions saliva hair |
| url | https://www.mdpi.com/2076-3425/12/4/485 |
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