Possible influence of MTHFR C677T polymorphism on serum lipid levels in Serbian school children
The effect of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism on serum lipid profiles is controversial. We randomly selected 530 healthy schoolchildren that were included in the Yugoslav Study of the Precursors of Atherosclerosis in School Children (YUSAD). The dete...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Belgrade, University of Novi Sad
2014-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402729D.pdf |
| _version_ | 1819209145316802560 |
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| author | Damnjanović Tatjana Luković Ljiljana Cvetković Dragana Jekić Biljana Bunjevački Vera Maksimović Nela Cvjetićanin Suzana Majkić-Singh Nada Slavko S. Novaković Ivana |
| author_facet | Damnjanović Tatjana Luković Ljiljana Cvetković Dragana Jekić Biljana Bunjevački Vera Maksimović Nela Cvjetićanin Suzana Majkić-Singh Nada Slavko S. Novaković Ivana |
| author_sort | Damnjanović Tatjana |
| collection | DOAJ |
| description | The effect of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene C677T
polymorphism on serum lipid profiles is controversial. We randomly selected
530 healthy schoolchildren that were included in the Yugoslav Study of the
Precursors of Atherosclerosis in School Children (YUSAD). The detected
frequencies of MTHFR 677TT genotypes and MTHFR 677T allele were 13.4% and
35.5%, respectively. The mean levels of total cholesterol, low-density
lipoprotein cholesterol and triglycerides were higher and high-density
lipoprotein cholesterol was lower in the group of children with TT genotype
compared with remaining genotypes. All differences were without statistical
significance. Our findings suggest that there is no influence of MTHFR C677T
gene variants on the lipid parameters in the population of Serbian children.
[Projekat Ministarstva nauke Republike Srbije, br. 175091] |
| first_indexed | 2024-12-23T05:50:38Z |
| format | Article |
| id | doaj.art-e90020c868a04e52ab66f879d5677bfe |
| institution | Directory Open Access Journal |
| issn | 0354-4664 1821-4339 |
| language | English |
| last_indexed | 2024-12-23T05:50:38Z |
| publishDate | 2014-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-e90020c868a04e52ab66f879d5677bfe2022-12-21T17:57:58ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392014-01-0166272973410.2298/ABS1402729D0354-46641402729DPossible influence of MTHFR C677T polymorphism on serum lipid levels in Serbian school childrenDamnjanović Tatjana0Luković Ljiljana1Cvetković Dragana2Jekić Biljana3Bunjevački Vera4Maksimović Nela5Cvjetićanin Suzana6Majkić-Singh Nada7Slavko S.8Novaković Ivana9Faculty of Medicine, Institute of Human Genetics, BelgradeFaculty of Medicine, Institute of Human Genetics, BelgradeFaculty of Biology, BelgradeFaculty of Medicine, Institute of Human Genetics, BelgradeFaculty of Medicine, Institute of Human Genetics, BelgradeFaculty of Medicine, Institute of Human Genetics, BelgradeFaculty of Medicine, Institute of Human Genetics, BelgradeFaculty of Pharmacy, BelgradeUniversity Children’s Hospital, BelgradeFaculty of Medicine, Institute of Human Genetics, BelgradeThe effect of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism on serum lipid profiles is controversial. We randomly selected 530 healthy schoolchildren that were included in the Yugoslav Study of the Precursors of Atherosclerosis in School Children (YUSAD). The detected frequencies of MTHFR 677TT genotypes and MTHFR 677T allele were 13.4% and 35.5%, respectively. The mean levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides were higher and high-density lipoprotein cholesterol was lower in the group of children with TT genotype compared with remaining genotypes. All differences were without statistical significance. Our findings suggest that there is no influence of MTHFR C677T gene variants on the lipid parameters in the population of Serbian children. [Projekat Ministarstva nauke Republike Srbije, br. 175091]http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402729D.pdfatherosclerosislipid levelsschoolchildrenMTHFR geneMTHFR 677T allelepolymorphism |
| spellingShingle | Damnjanović Tatjana Luković Ljiljana Cvetković Dragana Jekić Biljana Bunjevački Vera Maksimović Nela Cvjetićanin Suzana Majkić-Singh Nada Slavko S. Novaković Ivana Possible influence of MTHFR C677T polymorphism on serum lipid levels in Serbian school children Archives of Biological Sciences atherosclerosis lipid levels schoolchildren MTHFR gene MTHFR 677T allele polymorphism |
| title | Possible influence of MTHFR C677T polymorphism on serum lipid levels in Serbian school children |
| title_full | Possible influence of MTHFR C677T polymorphism on serum lipid levels in Serbian school children |
| title_fullStr | Possible influence of MTHFR C677T polymorphism on serum lipid levels in Serbian school children |
| title_full_unstemmed | Possible influence of MTHFR C677T polymorphism on serum lipid levels in Serbian school children |
| title_short | Possible influence of MTHFR C677T polymorphism on serum lipid levels in Serbian school children |
| title_sort | possible influence of mthfr c677t polymorphism on serum lipid levels in serbian school children |
| topic | atherosclerosis lipid levels schoolchildren MTHFR gene MTHFR 677T allele polymorphism |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402729D.pdf |
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