Hard-Shelled Glycol Chitosan Nanoparticles for Dual MRI/US Detection of Drug Delivery/Release: A Proof-of-Concept Study
This paper describes a novel nanoformulation for dual MRI/US in vivo monitoring of drug delivery/release. The nanosystem was made of a perfluoropentane core coated with phospholipids stabilized by glycol chitosan crosslinked with triphosphate ions, and it was co-loaded with the prodrug prednisolone...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/13/15/2227 |
| _version_ | 1797586274922528768 |
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| author | Simona Baroni Monica Argenziano Francesca La Cava Marco Soster Francesca Garello David Lembo Roberta Cavalli Enzo Terreno |
| author_facet | Simona Baroni Monica Argenziano Francesca La Cava Marco Soster Francesca Garello David Lembo Roberta Cavalli Enzo Terreno |
| author_sort | Simona Baroni |
| collection | DOAJ |
| description | This paper describes a novel nanoformulation for dual MRI/US in vivo monitoring of drug delivery/release. The nanosystem was made of a perfluoropentane core coated with phospholipids stabilized by glycol chitosan crosslinked with triphosphate ions, and it was co-loaded with the prodrug prednisolone phosphate (PLP) and the structurally similar MRI agent Gd-DTPAMA-CHOL. Importantly, the in vitro release of PLP and Gd-DTPAMA-CHOL from the nanocarrier showed similar profiles, validating the potential impact of the MRI agent as an imaging reporter for the drug release. On the other hand, the nanobubbles were also detectable by US imaging both in vitro and in vivo. Therefore, the temporal evolution of both MRI and US contrast after the administration of the proposed nanosystem could report on the delivery and the release kinetics of the transported drug in a given lesion. |
| first_indexed | 2024-03-11T00:21:00Z |
| format | Article |
| id | doaj.art-e9029172e60b4b3dbbfaeda9f17b6827 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-11T00:21:00Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-e9029172e60b4b3dbbfaeda9f17b68272023-11-18T23:21:51ZengMDPI AGNanomaterials2079-49912023-08-011315222710.3390/nano13152227Hard-Shelled Glycol Chitosan Nanoparticles for Dual MRI/US Detection of Drug Delivery/Release: A Proof-of-Concept StudySimona Baroni0Monica Argenziano1Francesca La Cava2Marco Soster3Francesca Garello4David Lembo5Roberta Cavalli6Enzo Terreno7Molecular and Preclinical Imaging Centers, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, ItalyDepartment of Drug Science and Technology, University of Torino, Via P. Giuria 9, 10125 Torino, ItalyMolecular and Preclinical Imaging Centers, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, ItalyDepartment of Drug Science and Technology, University of Torino, Via P. Giuria 9, 10125 Torino, ItalyMolecular and Preclinical Imaging Centers, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, ItalyDepartment of Clinical and Biological Sciences, University of Torino, S. Luigi Gonzaga Hospital, Regione Gonzole, 10, 10043 Orbassano, ItalyDepartment of Drug Science and Technology, University of Torino, Via P. Giuria 9, 10125 Torino, ItalyMolecular and Preclinical Imaging Centers, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, ItalyThis paper describes a novel nanoformulation for dual MRI/US in vivo monitoring of drug delivery/release. The nanosystem was made of a perfluoropentane core coated with phospholipids stabilized by glycol chitosan crosslinked with triphosphate ions, and it was co-loaded with the prodrug prednisolone phosphate (PLP) and the structurally similar MRI agent Gd-DTPAMA-CHOL. Importantly, the in vitro release of PLP and Gd-DTPAMA-CHOL from the nanocarrier showed similar profiles, validating the potential impact of the MRI agent as an imaging reporter for the drug release. On the other hand, the nanobubbles were also detectable by US imaging both in vitro and in vivo. Therefore, the temporal evolution of both MRI and US contrast after the administration of the proposed nanosystem could report on the delivery and the release kinetics of the transported drug in a given lesion.https://www.mdpi.com/2079-4991/13/15/2227theranosticsMRIultrasound imagingnanobubblesGd(III) complexesrelaxometry |
| spellingShingle | Simona Baroni Monica Argenziano Francesca La Cava Marco Soster Francesca Garello David Lembo Roberta Cavalli Enzo Terreno Hard-Shelled Glycol Chitosan Nanoparticles for Dual MRI/US Detection of Drug Delivery/Release: A Proof-of-Concept Study Nanomaterials theranostics MRI ultrasound imaging nanobubbles Gd(III) complexes relaxometry |
| title | Hard-Shelled Glycol Chitosan Nanoparticles for Dual MRI/US Detection of Drug Delivery/Release: A Proof-of-Concept Study |
| title_full | Hard-Shelled Glycol Chitosan Nanoparticles for Dual MRI/US Detection of Drug Delivery/Release: A Proof-of-Concept Study |
| title_fullStr | Hard-Shelled Glycol Chitosan Nanoparticles for Dual MRI/US Detection of Drug Delivery/Release: A Proof-of-Concept Study |
| title_full_unstemmed | Hard-Shelled Glycol Chitosan Nanoparticles for Dual MRI/US Detection of Drug Delivery/Release: A Proof-of-Concept Study |
| title_short | Hard-Shelled Glycol Chitosan Nanoparticles for Dual MRI/US Detection of Drug Delivery/Release: A Proof-of-Concept Study |
| title_sort | hard shelled glycol chitosan nanoparticles for dual mri us detection of drug delivery release a proof of concept study |
| topic | theranostics MRI ultrasound imaging nanobubbles Gd(III) complexes relaxometry |
| url | https://www.mdpi.com/2079-4991/13/15/2227 |
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