Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice

Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice

Mice deficient for the cellular prion protein (PrPC) do not develop prion disease; accordingly, gene-based strategies to diminish PrPC expression are of interest. We synthesized a series of chemically modified antisense oligonucleotides (ASOs) targeted against mouse Prnp messenger RNA (mRNA) and ide...

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Bibliographic Details
Main Authors: Karah Nazor Friberg, Gene Hung, Ed Wancewicz, Kurt Giles, Chris Black, Sue Freier, Frank Bennett, Stephen J DeArmond, Yevgeniy Freyman, Pierre Lessard, Sina Ghaemmaghami, Stanley B Prusiner
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300671

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