Simple Plasma Test Based on a MoSe2 SERS Platform for the Specific Diagnosis of Alzheimer’s Disease
As a significant Alzheimer’s disease (AD)-specific biomarker, the examination of brain-derived tau (BD-tau) is significant in terms of the diagnosis and differentiation of neurological disorders. In this research, sea urchin-like MoSe2 microspheres were synthesized by hydrothermal synthesis, reveali...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society
2023-05-01
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| Series: | Chemical & Biomedical Imaging |
| Online Access: | https://doi.org/10.1021/cbmi.3c00041 |
| _version_ | 1797739861717811200 |
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| author | Yan Zhou Jianyan Li Tingting Zheng Yang Tian |
| author_facet | Yan Zhou Jianyan Li Tingting Zheng Yang Tian |
| author_sort | Yan Zhou |
| collection | DOAJ |
| description | As a significant Alzheimer’s disease (AD)-specific biomarker, the examination of brain-derived tau (BD-tau) is significant in terms of the diagnosis and differentiation of neurological disorders. In this research, sea urchin-like MoSe2 microspheres were synthesized by hydrothermal synthesis, revealing significant SERS activity, and the enhancement factor (EF) reached 1.44 × 107. The remarkable EF was mainly ascribed to the (i) charge transfer between MoSe2 and MB, (ii) MB molecule’s resonance effect, and (iii) molecular enrichment of porous structures. Through an aptamer-antibody sandwich method, we prepared a BD-tau SERS detection platform based on sea urchin-like MoSe2 microspheres. The liner range was 0.05–200.00 pM with a limit of detection (LOD) as low as 0.028 pM. Besides, the developed detection platform demonstrated excellent selectivity and enabled early diagnosis of AD patients. In general, the MoSe2 SERS detection platform can well detect the concentration of BD-tau in mouse plasma samples, showing great potential in specific recognition of AD among neurodegenerative diseases. |
| first_indexed | 2024-03-12T14:04:17Z |
| format | Article |
| id | doaj.art-e9068134a85448bf9c142deba7fc46a2 |
| institution | Directory Open Access Journal |
| issn | 2832-3637 |
| language | English |
| last_indexed | 2024-03-12T14:04:17Z |
| publishDate | 2023-05-01 |
| publisher | American Chemical Society |
| record_format | Article |
| series | Chemical & Biomedical Imaging |
| spelling | doaj.art-e9068134a85448bf9c142deba7fc46a22023-08-21T17:58:19ZengAmerican Chemical SocietyChemical & Biomedical Imaging2832-36372023-05-011218619110.1021/cbmi.3c00041Simple Plasma Test Based on a MoSe2 SERS Platform for the Specific Diagnosis of Alzheimer’s DiseaseYan Zhou0Jianyan Li1Tingting Zheng2Yang Tian3State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai, P. R. ChinaShanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, P. R. ChinaShanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, P. R. ChinaState Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai, P. R. ChinaAs a significant Alzheimer’s disease (AD)-specific biomarker, the examination of brain-derived tau (BD-tau) is significant in terms of the diagnosis and differentiation of neurological disorders. In this research, sea urchin-like MoSe2 microspheres were synthesized by hydrothermal synthesis, revealing significant SERS activity, and the enhancement factor (EF) reached 1.44 × 107. The remarkable EF was mainly ascribed to the (i) charge transfer between MoSe2 and MB, (ii) MB molecule’s resonance effect, and (iii) molecular enrichment of porous structures. Through an aptamer-antibody sandwich method, we prepared a BD-tau SERS detection platform based on sea urchin-like MoSe2 microspheres. The liner range was 0.05–200.00 pM with a limit of detection (LOD) as low as 0.028 pM. Besides, the developed detection platform demonstrated excellent selectivity and enabled early diagnosis of AD patients. In general, the MoSe2 SERS detection platform can well detect the concentration of BD-tau in mouse plasma samples, showing great potential in specific recognition of AD among neurodegenerative diseases.https://doi.org/10.1021/cbmi.3c00041 |
| spellingShingle | Yan Zhou Jianyan Li Tingting Zheng Yang Tian Simple Plasma Test Based on a MoSe2 SERS Platform for the Specific Diagnosis of Alzheimer’s Disease Chemical & Biomedical Imaging |
| title | Simple Plasma Test Based on a MoSe2 SERS Platform for the Specific Diagnosis of Alzheimer’s Disease |
| title_full | Simple Plasma Test Based on a MoSe2 SERS Platform for the Specific Diagnosis of Alzheimer’s Disease |
| title_fullStr | Simple Plasma Test Based on a MoSe2 SERS Platform for the Specific Diagnosis of Alzheimer’s Disease |
| title_full_unstemmed | Simple Plasma Test Based on a MoSe2 SERS Platform for the Specific Diagnosis of Alzheimer’s Disease |
| title_short | Simple Plasma Test Based on a MoSe2 SERS Platform for the Specific Diagnosis of Alzheimer’s Disease |
| title_sort | simple plasma test based on a mose2 sers platform for the specific diagnosis of alzheimer s disease |
| url | https://doi.org/10.1021/cbmi.3c00041 |
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