Impact of repeated four-monthly anthelmintic treatment on <b><it>Plasmodium </it></b>infection in preschool children: a double-blind placebo-controlled randomized trial
<p>Abstract</p> <p>Background</p> <p>Helminth infections can alter susceptibility to malaria. Studies need to determine whether or not deworming programs can impact on <it>Plasmodium </it>infections in preschool children.</p> <p>Methods</p>...
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| Format: | Article |
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BMC
2010-09-01
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| Series: | BMC Infectious Diseases |
| Online Access: | http://www.biomedcentral.com/1471-2334/10/277 |
| _version_ | 1818823983453175808 |
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| author | Ranford-Cartwright Lisa Bruce Marian C Abiona Titilayo C Molloy Sile F Asaolu Samuel O Jackson Andrew L Kirwan Patrick O' Neill Sandra M Holland Celia V |
| author_facet | Ranford-Cartwright Lisa Bruce Marian C Abiona Titilayo C Molloy Sile F Asaolu Samuel O Jackson Andrew L Kirwan Patrick O' Neill Sandra M Holland Celia V |
| author_sort | Ranford-Cartwright Lisa |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Helminth infections can alter susceptibility to malaria. Studies need to determine whether or not deworming programs can impact on <it>Plasmodium </it>infections in preschool children.</p> <p>Methods</p> <p>A double-blind placebo-controlled randomised trial was conducted to investigate the impact of anthelmintic treatment on <it>Plasmodium </it>infection in children aged 12-59 months. Children were randomly assigned to receive either albendazole or placebo every four months for 12 months with a follow-up at 14 months.</p> <p>Results</p> <p>320 children (out of 1228, 26.1%) complied with all the follow-up assessments. <it>Plasmodium </it>prevalence and mean <it>Plasmodium </it>parasite density was significantly higher in the treatment group (44.9% and 2319 ± SE 511) compared to the placebo group (33.3% and 1471 ± 341) at baseline. The odds of having <it>Plasmodium </it>infection increased over time for children in both the placebo and treatment groups, however this increase was significantly slower for children in the treatment group (P = 0.002). By month 14, mean <it>Plasmodium </it>density had increased by 156% in the placebo group and 98% in the treatment group but the rate of change in <it>Plasmodium </it>density was not significantly different between the groups. The change from baseline in haemoglobin had a steeper increase among children in the treatment group when compared to the placebo group but this was not statistically significant.</p> <p>Conclusions</p> <p>Repeated four-monthly anthelminthic treatments for 14 months resulted in a significantly lower increase in the prevalence of <it>Plasmodium </it>infection in preschool children which coincided with a reduction in both the prevalence and intensity of <it>A. lumbricoides </it>infections.</p> <p>Trial Registration</p> <p>Current controlled trials ISRCTN44215995</p> |
| first_indexed | 2024-12-18T23:48:39Z |
| format | Article |
| id | doaj.art-e908bf996ada4cf292acf308b419007e |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-18T23:48:39Z |
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| spelling | doaj.art-e908bf996ada4cf292acf308b419007e2022-12-21T20:47:08ZengBMCBMC Infectious Diseases1471-23342010-09-0110127710.1186/1471-2334-10-277Impact of repeated four-monthly anthelmintic treatment on <b><it>Plasmodium </it></b>infection in preschool children: a double-blind placebo-controlled randomized trialRanford-Cartwright LisaBruce Marian CAbiona Titilayo CMolloy Sile FAsaolu Samuel OJackson Andrew LKirwan PatrickO' Neill Sandra MHolland Celia V<p>Abstract</p> <p>Background</p> <p>Helminth infections can alter susceptibility to malaria. Studies need to determine whether or not deworming programs can impact on <it>Plasmodium </it>infections in preschool children.</p> <p>Methods</p> <p>A double-blind placebo-controlled randomised trial was conducted to investigate the impact of anthelmintic treatment on <it>Plasmodium </it>infection in children aged 12-59 months. Children were randomly assigned to receive either albendazole or placebo every four months for 12 months with a follow-up at 14 months.</p> <p>Results</p> <p>320 children (out of 1228, 26.1%) complied with all the follow-up assessments. <it>Plasmodium </it>prevalence and mean <it>Plasmodium </it>parasite density was significantly higher in the treatment group (44.9% and 2319 ± SE 511) compared to the placebo group (33.3% and 1471 ± 341) at baseline. The odds of having <it>Plasmodium </it>infection increased over time for children in both the placebo and treatment groups, however this increase was significantly slower for children in the treatment group (P = 0.002). By month 14, mean <it>Plasmodium </it>density had increased by 156% in the placebo group and 98% in the treatment group but the rate of change in <it>Plasmodium </it>density was not significantly different between the groups. The change from baseline in haemoglobin had a steeper increase among children in the treatment group when compared to the placebo group but this was not statistically significant.</p> <p>Conclusions</p> <p>Repeated four-monthly anthelminthic treatments for 14 months resulted in a significantly lower increase in the prevalence of <it>Plasmodium </it>infection in preschool children which coincided with a reduction in both the prevalence and intensity of <it>A. lumbricoides </it>infections.</p> <p>Trial Registration</p> <p>Current controlled trials ISRCTN44215995</p>http://www.biomedcentral.com/1471-2334/10/277 |
| spellingShingle | Ranford-Cartwright Lisa Bruce Marian C Abiona Titilayo C Molloy Sile F Asaolu Samuel O Jackson Andrew L Kirwan Patrick O' Neill Sandra M Holland Celia V Impact of repeated four-monthly anthelmintic treatment on <b><it>Plasmodium </it></b>infection in preschool children: a double-blind placebo-controlled randomized trial BMC Infectious Diseases |
| title | Impact of repeated four-monthly anthelmintic treatment on <b><it>Plasmodium </it></b>infection in preschool children: a double-blind placebo-controlled randomized trial |
| title_full | Impact of repeated four-monthly anthelmintic treatment on <b><it>Plasmodium </it></b>infection in preschool children: a double-blind placebo-controlled randomized trial |
| title_fullStr | Impact of repeated four-monthly anthelmintic treatment on <b><it>Plasmodium </it></b>infection in preschool children: a double-blind placebo-controlled randomized trial |
| title_full_unstemmed | Impact of repeated four-monthly anthelmintic treatment on <b><it>Plasmodium </it></b>infection in preschool children: a double-blind placebo-controlled randomized trial |
| title_short | Impact of repeated four-monthly anthelmintic treatment on <b><it>Plasmodium </it></b>infection in preschool children: a double-blind placebo-controlled randomized trial |
| title_sort | impact of repeated four monthly anthelmintic treatment on b it plasmodium it b infection in preschool children a double blind placebo controlled randomized trial |
| url | http://www.biomedcentral.com/1471-2334/10/277 |
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