L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial
L-carnitine tartrate has been shown to improve relatively short-term recovery among athletes. However, there is a lack of research on the longer-term effects in the general population. Objective: The primary objectives of this randomized double-blind, placebo-controlled trial were to evaluate the ef...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/10/3432 |
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| author | Matthew Stefan Matthew Sharp Raad Gheith Ryan Lowery Charlie Ottinger Jacob Wilson Shane Durkee Aouatef Bellamine |
| author_facet | Matthew Stefan Matthew Sharp Raad Gheith Ryan Lowery Charlie Ottinger Jacob Wilson Shane Durkee Aouatef Bellamine |
| author_sort | Matthew Stefan |
| collection | DOAJ |
| description | L-carnitine tartrate has been shown to improve relatively short-term recovery among athletes. However, there is a lack of research on the longer-term effects in the general population. Objective: The primary objectives of this randomized double-blind, placebo-controlled trial were to evaluate the effects of daily L-carnitine tartrate supplementation for 5 weeks on recovery and fatigue. Method: In this study, eighty participants, 21- to 65-years-old, were recruited. Participants were split into two groups of forty participants each, a placebo, and a L-carnitine Tartrate group. Seventy-three participants completed a maintenance exercise training program that culminated in a high-volume exercise challenge. Results: Compared to placebo, L-carnitine tartrate supplementation was able to improve perceived recovery and soreness (<i>p</i> = 0.021), and lower serum creatine kinase (<i>p</i> = 0.016). In addition, L-carnitine tartrate supplementation was able to blunt declines in strength and power compared to placebo following an exercise challenge. Two sub-analyses indicated that these results were independent of gender and age. Interestingly, serum superoxide dismutase levels increased significantly among those supplementing with L-carnitine tartrate. Conclusions: These findings agree with previous observations among healthy adult subjects and demonstrate that L-carnitine tartrate supplementation beyond 35 days is beneficial for improving recovery and reducing fatigue following exercise across gender and age. |
| first_indexed | 2024-03-10T06:18:41Z |
| format | Article |
| id | doaj.art-e90b399bae2c4e239dd08d34641700d1 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T06:18:41Z |
| publishDate | 2021-09-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e90b399bae2c4e239dd08d34641700d12023-11-22T19:28:24ZengMDPI AGNutrients2072-66432021-09-011310343210.3390/nu13103432L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled TrialMatthew Stefan0Matthew Sharp1Raad Gheith2Ryan Lowery3Charlie Ottinger4Jacob Wilson5Shane Durkee6Aouatef Bellamine7Applied Science & Performance Institute, Research Division, Tampa, FL 33607, USAApplied Science & Performance Institute, Research Division, Tampa, FL 33607, USAApplied Science & Performance Institute, Research Division, Tampa, FL 33607, USAApplied Science & Performance Institute, Research Division, Tampa, FL 33607, USAApplied Science & Performance Institute, Research Division, Tampa, FL 33607, USAApplied Science & Performance Institute, Research Division, Tampa, FL 33607, USALonza Consumer Health Inc., Morristown, NJ 07960, USALonza Consumer Health Inc., Morristown, NJ 07960, USAL-carnitine tartrate has been shown to improve relatively short-term recovery among athletes. However, there is a lack of research on the longer-term effects in the general population. Objective: The primary objectives of this randomized double-blind, placebo-controlled trial were to evaluate the effects of daily L-carnitine tartrate supplementation for 5 weeks on recovery and fatigue. Method: In this study, eighty participants, 21- to 65-years-old, were recruited. Participants were split into two groups of forty participants each, a placebo, and a L-carnitine Tartrate group. Seventy-three participants completed a maintenance exercise training program that culminated in a high-volume exercise challenge. Results: Compared to placebo, L-carnitine tartrate supplementation was able to improve perceived recovery and soreness (<i>p</i> = 0.021), and lower serum creatine kinase (<i>p</i> = 0.016). In addition, L-carnitine tartrate supplementation was able to blunt declines in strength and power compared to placebo following an exercise challenge. Two sub-analyses indicated that these results were independent of gender and age. Interestingly, serum superoxide dismutase levels increased significantly among those supplementing with L-carnitine tartrate. Conclusions: These findings agree with previous observations among healthy adult subjects and demonstrate that L-carnitine tartrate supplementation beyond 35 days is beneficial for improving recovery and reducing fatigue following exercise across gender and age.https://www.mdpi.com/2072-6643/13/10/3432carnitinerecoveryfatigueexerciseL-carnitine tartratemuscle damage antioxidant |
| spellingShingle | Matthew Stefan Matthew Sharp Raad Gheith Ryan Lowery Charlie Ottinger Jacob Wilson Shane Durkee Aouatef Bellamine L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial Nutrients carnitine recovery fatigue exercise L-carnitine tartrate muscle damage antioxidant |
| title | L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_full | L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_fullStr | L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_full_unstemmed | L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_short | L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_sort | l carnitine tartrate supplementation for 5 weeks improves exercise recovery in men and women a randomized double blind placebo controlled trial |
| topic | carnitine recovery fatigue exercise L-carnitine tartrate muscle damage antioxidant |
| url | https://www.mdpi.com/2072-6643/13/10/3432 |
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