Hyperthyroidism in the pregnant woman: Maternal and fetal aspects
Hyperthyroidism during pregnancy is uncommon. Nonetheless, prompt identification and adequate management of hyperthyroidism in a pregnant woman is essential, because uncontrolled thyrotoxicosis significantly increases the risk of maternal and fetal complications. Also, fetal prognosis may be affecte...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-06-01
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| Series: | Journal of Clinical & Translational Endocrinology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214623719300304 |
| _version_ | 1828766119616315392 |
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| author | Mariacarla Moleti Maria Di Mauro Giacomo Sturniolo Marco Russo Francesco Vermiglio |
| author_facet | Mariacarla Moleti Maria Di Mauro Giacomo Sturniolo Marco Russo Francesco Vermiglio |
| author_sort | Mariacarla Moleti |
| collection | DOAJ |
| description | Hyperthyroidism during pregnancy is uncommon. Nonetheless, prompt identification and adequate management of hyperthyroidism in a pregnant woman is essential, because uncontrolled thyrotoxicosis significantly increases the risk of maternal and fetal complications. Also, fetal prognosis may be affected by the transplacental passage of maternal thyroid stimulating antibodies or thyrostatic agents, both of which may disrupt fetal thyroid function. Birth defects have been reported in association with the use of antithyroid drugs during early pregnancy. Although rarely, offspring of mothers with Graves’ disease may develop fetal/neonatal hyperthyroidism, the management of which requires a close collaboration between endocrinologists, obstetricians, and neonatologists.Because of the above considerations, the management of pregnant and lactating women with hyperthyroidism requires special care, bearing in mind that both maternal thyroid excess per se and related treatments may adversely affect the newborn’s health.In this review we discuss the diagnosis and management of hyperthyroidism in pregnancy, along with the impact of thyrotoxicosis and medications on fetal outcome. Keywords: Pregnancy, Hyperthyroidism, Thyrotoxicosis, Gestational transient thyrotoxicosis, Graves’ disease |
| first_indexed | 2024-12-11T06:59:32Z |
| format | Article |
| id | doaj.art-e90bf6b29a2f4bf4ac2139c3d220a4d6 |
| institution | Directory Open Access Journal |
| issn | 2214-6237 |
| language | English |
| last_indexed | 2024-12-11T06:59:32Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical & Translational Endocrinology |
| spelling | doaj.art-e90bf6b29a2f4bf4ac2139c3d220a4d62022-12-22T01:16:39ZengElsevierJournal of Clinical & Translational Endocrinology2214-62372019-06-0116Hyperthyroidism in the pregnant woman: Maternal and fetal aspectsMariacarla Moleti0Maria Di Mauro1Giacomo Sturniolo2Marco Russo3Francesco Vermiglio4Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 1, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 1, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 1, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 1, 98125 Messina, ItalyCorresponding author at: Via Consolare Valeria, 1, 98125 Messina, Italy.; Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 1, 98125 Messina, ItalyHyperthyroidism during pregnancy is uncommon. Nonetheless, prompt identification and adequate management of hyperthyroidism in a pregnant woman is essential, because uncontrolled thyrotoxicosis significantly increases the risk of maternal and fetal complications. Also, fetal prognosis may be affected by the transplacental passage of maternal thyroid stimulating antibodies or thyrostatic agents, both of which may disrupt fetal thyroid function. Birth defects have been reported in association with the use of antithyroid drugs during early pregnancy. Although rarely, offspring of mothers with Graves’ disease may develop fetal/neonatal hyperthyroidism, the management of which requires a close collaboration between endocrinologists, obstetricians, and neonatologists.Because of the above considerations, the management of pregnant and lactating women with hyperthyroidism requires special care, bearing in mind that both maternal thyroid excess per se and related treatments may adversely affect the newborn’s health.In this review we discuss the diagnosis and management of hyperthyroidism in pregnancy, along with the impact of thyrotoxicosis and medications on fetal outcome. Keywords: Pregnancy, Hyperthyroidism, Thyrotoxicosis, Gestational transient thyrotoxicosis, Graves’ diseasehttp://www.sciencedirect.com/science/article/pii/S2214623719300304 |
| spellingShingle | Mariacarla Moleti Maria Di Mauro Giacomo Sturniolo Marco Russo Francesco Vermiglio Hyperthyroidism in the pregnant woman: Maternal and fetal aspects Journal of Clinical & Translational Endocrinology |
| title | Hyperthyroidism in the pregnant woman: Maternal and fetal aspects |
| title_full | Hyperthyroidism in the pregnant woman: Maternal and fetal aspects |
| title_fullStr | Hyperthyroidism in the pregnant woman: Maternal and fetal aspects |
| title_full_unstemmed | Hyperthyroidism in the pregnant woman: Maternal and fetal aspects |
| title_short | Hyperthyroidism in the pregnant woman: Maternal and fetal aspects |
| title_sort | hyperthyroidism in the pregnant woman maternal and fetal aspects |
| url | http://www.sciencedirect.com/science/article/pii/S2214623719300304 |
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