4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling

4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling

Abstract Background Septic acute kidney injury (S-AKI) is the leading form of acute kidney failure among hospitalized patients, and the inflammatory response is involved in this process. 4-octyl itaconate (4-OI) is a multi-target itaconate derivative with potent anti-inflammatory action. However, it...

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Bibliographic Details
Main Authors: Lujun Xu, Juan Cai, Chenrui Li, Ming Yang, Tongyue Duan, Qing Zhao, Yiyun Xi, Liya Sun, Liyu He, Chengyuan Tang, Lin Sun
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Molecular Medicine
Subjects:
sepsis
Acute kidney injury
4-octyl itaconate
Oxidative stress
Inflammation
Mitophagy
Online Access:https://doi.org/10.1186/s10020-023-00631-8

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