Intracellular VHHs to monitor and modulate GPCR signaling
Single-domain antibody fragments, also known as VHHs or nanobodies, have opened promising avenues in therapeutics and in exploration of intracellular processes. Because of their unique structural properties, they can reach cryptic regions in their cognate antigen. Intracellular VHHs/antibodies prima...
Main Authors: | Pauline Raynaud, Camille Gauthier, Vinesh Jugnarain, Frédéric Jean-Alphonse, Eric Reiter, Gilles Bruneau, Pascale Crépieux |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-11-01
|
Series: | Frontiers in Endocrinology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1048601/full |
Similar Items
-
Assessing Gonadotropin Receptor Function By Resonance Energy Transfer-Based Assays
by: Mohammed Akli eAyoub, et al.
Published: (2015-08-01) -
Phosphorylation of β-arrestin2 at Thr383 by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs
by: Elisabeth Cassier, et al.
Published: (2017-02-01) -
Generation and Application of Fluorescent Anti-Human β2-Microglobulin VHHs via Amino Modification
by: Chundong Huang, et al.
Published: (2019-07-01) -
DEER Analysis of GPCR Conformational Heterogeneity
by: Matthias Elgeti, et al.
Published: (2021-05-01) -
Combined Multiplexed Phage Display, High-Throughput Sequencing, and Functional Assays as a Platform for Identifying Modulatory VHHs Targeting the FSHR
by: Anielka Zehnaker, et al.
Published: (2023-11-01)