Obtaining a Reliable Diagnostic Biomarker for Diabetes Mellitus by Standardizing Salivary Glucose Measurements
Salivary glucose is frequently utilized in diabetes mellitus (DM), and it might be proposed as a potential biomarker candidate for DM, as it is non-invasive and cost-effective and achieves adequate diagnostic performance for DM patients. However, salivary glucose levels may change under specific con...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/10/1335 |
| _version_ | 1797474968859049984 |
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| author | Yangyang Cui Hankun Zhang Song Wang Junzhe Lu Jinmei He Lanlan Liu Weiqiang Liu |
| author_facet | Yangyang Cui Hankun Zhang Song Wang Junzhe Lu Jinmei He Lanlan Liu Weiqiang Liu |
| author_sort | Yangyang Cui |
| collection | DOAJ |
| description | Salivary glucose is frequently utilized in diabetes mellitus (DM), and it might be proposed as a potential biomarker candidate for DM, as it is non-invasive and cost-effective and achieves adequate diagnostic performance for DM patients. However, salivary glucose levels may change under specific conditions. It is consequently essential to maintain a consistent strategy for measuring saliva, taking into account the possibility of external factors influencing salivary glucose levels. In this study, we analyzed salivary glucose levels under different handling conditions and donor-dependent factors, including age, interdiurnal variations, and collection and processing methods. A structured questionnaire was used to determine the symptoms and predisposing factors of DM. The glucose oxidase peroxidase method was used to estimate glucose levels in the blood and saliva of people in a fasting state. The aim of this study is to investigate the effect of such conditions on salivary glucose levels. We found that these extraneous variables should be taken into account in the future when salivary glucose is used as a predictive biomarker for DM. |
| first_indexed | 2024-03-09T20:38:24Z |
| format | Article |
| id | doaj.art-e90d869a1a394ea885f3f7af2ab1161e |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:38:24Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-e90d869a1a394ea885f3f7af2ab1161e2023-11-23T23:07:00ZengMDPI AGBiomolecules2218-273X2022-09-011210133510.3390/biom12101335Obtaining a Reliable Diagnostic Biomarker for Diabetes Mellitus by Standardizing Salivary Glucose MeasurementsYangyang Cui0Hankun Zhang1Song Wang2Junzhe Lu3Jinmei He4Lanlan Liu5Weiqiang Liu6Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, ChinaTsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, ChinaBiomechanics and Biotechnology Laboratory, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, ChinaBiomechanics and Biotechnology Laboratory, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, ChinaBiomechanics and Biotechnology Laboratory, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, ChinaBiomechanics and Biotechnology Laboratory, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, ChinaTsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, ChinaSalivary glucose is frequently utilized in diabetes mellitus (DM), and it might be proposed as a potential biomarker candidate for DM, as it is non-invasive and cost-effective and achieves adequate diagnostic performance for DM patients. However, salivary glucose levels may change under specific conditions. It is consequently essential to maintain a consistent strategy for measuring saliva, taking into account the possibility of external factors influencing salivary glucose levels. In this study, we analyzed salivary glucose levels under different handling conditions and donor-dependent factors, including age, interdiurnal variations, and collection and processing methods. A structured questionnaire was used to determine the symptoms and predisposing factors of DM. The glucose oxidase peroxidase method was used to estimate glucose levels in the blood and saliva of people in a fasting state. The aim of this study is to investigate the effect of such conditions on salivary glucose levels. We found that these extraneous variables should be taken into account in the future when salivary glucose is used as a predictive biomarker for DM.https://www.mdpi.com/2218-273X/12/10/1335salivasalivary glucosestandardizingdiabetes mellitussample collection |
| spellingShingle | Yangyang Cui Hankun Zhang Song Wang Junzhe Lu Jinmei He Lanlan Liu Weiqiang Liu Obtaining a Reliable Diagnostic Biomarker for Diabetes Mellitus by Standardizing Salivary Glucose Measurements Biomolecules saliva salivary glucose standardizing diabetes mellitus sample collection |
| title | Obtaining a Reliable Diagnostic Biomarker for Diabetes Mellitus by Standardizing Salivary Glucose Measurements |
| title_full | Obtaining a Reliable Diagnostic Biomarker for Diabetes Mellitus by Standardizing Salivary Glucose Measurements |
| title_fullStr | Obtaining a Reliable Diagnostic Biomarker for Diabetes Mellitus by Standardizing Salivary Glucose Measurements |
| title_full_unstemmed | Obtaining a Reliable Diagnostic Biomarker for Diabetes Mellitus by Standardizing Salivary Glucose Measurements |
| title_short | Obtaining a Reliable Diagnostic Biomarker for Diabetes Mellitus by Standardizing Salivary Glucose Measurements |
| title_sort | obtaining a reliable diagnostic biomarker for diabetes mellitus by standardizing salivary glucose measurements |
| topic | saliva salivary glucose standardizing diabetes mellitus sample collection |
| url | https://www.mdpi.com/2218-273X/12/10/1335 |
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