Innate Lymphoid Cells in Human Pregnancy
Innate lymphoid cells (ILCs) are a new set of cells considered to be a part of the innate immune system. ILCs are classified into five subsets (according to their transcription factors and cytokine profile) as natural killer cells (NK cells), group 1 ILCs, group 2 ILCs, group 3 ILCs, and lymphoid ti...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-11-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.551707/full |
| _version_ | 1818602729730211840 |
|---|---|
| author | João Mendes João Mendes João Mendes João Mendes Ana Luísa Areia Ana Luísa Areia Ana Luísa Areia Ana Luísa Areia Ana Luísa Areia Paulo Rodrigues-Santos Paulo Rodrigues-Santos Paulo Rodrigues-Santos Paulo Rodrigues-Santos Paulo Rodrigues-Santos Manuel Santos-Rosa Anabela Mota-Pinto Anabela Mota-Pinto Anabela Mota-Pinto Anabela Mota-Pinto |
| author_facet | João Mendes João Mendes João Mendes João Mendes Ana Luísa Areia Ana Luísa Areia Ana Luísa Areia Ana Luísa Areia Ana Luísa Areia Paulo Rodrigues-Santos Paulo Rodrigues-Santos Paulo Rodrigues-Santos Paulo Rodrigues-Santos Paulo Rodrigues-Santos Manuel Santos-Rosa Anabela Mota-Pinto Anabela Mota-Pinto Anabela Mota-Pinto Anabela Mota-Pinto |
| author_sort | João Mendes |
| collection | DOAJ |
| description | Innate lymphoid cells (ILCs) are a new set of cells considered to be a part of the innate immune system. ILCs are classified into five subsets (according to their transcription factors and cytokine profile) as natural killer cells (NK cells), group 1 ILCs, group 2 ILCs, group 3 ILCs, and lymphoid tissue inducers (LTi). Functionally, these cells resemble the T helper population but lack the expression of recombinant genes, which is essential for the formation of T cell receptors. In this work, the authors address the distinction between peripheral and decidual NK cells, highlighting their diversity in ILC biology and its relevance to human pregnancy. ILCs are effector cells that are important in promoting immunity, inflammation, and tissue repair. Recent studies have directed their attention to ILC actions in pregnancy. Dysregulation or expansion of pro-inflammatory ILC populations as well as abnormal tolerogenic responses may directly interfere with pregnancy, ultimately resulting in pregnancy loss or adverse outcomes. In this review, we characterize these cells, considering recent findings and addressing knowledge gaps in perinatal medicine in the context of ILC biology. Moreover, we discuss the relevance of these cells not only to the process of immune tolerance, but also in disease. |
| first_indexed | 2024-12-16T13:11:55Z |
| format | Article |
| id | doaj.art-e9100df6e2ff4bed81f0ba1f9fbbaa31 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T13:11:55Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e9100df6e2ff4bed81f0ba1f9fbbaa312022-12-21T22:30:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-11-011110.3389/fimmu.2020.551707551707Innate Lymphoid Cells in Human PregnancyJoão Mendes0João Mendes1João Mendes2João Mendes3Ana Luísa Areia4Ana Luísa Areia5Ana Luísa Areia6Ana Luísa Areia7Ana Luísa Areia8Paulo Rodrigues-Santos9Paulo Rodrigues-Santos10Paulo Rodrigues-Santos11Paulo Rodrigues-Santos12Paulo Rodrigues-Santos13Manuel Santos-Rosa14Anabela Mota-Pinto15Anabela Mota-Pinto16Anabela Mota-Pinto17Anabela Mota-Pinto18Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Coimbra, PortugalFaculty of Medicine, Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), University of Coimbra, Coimbra, PortugalFaculty of Medicine, General Pathology Institute, University of Coimbra, Coimbra, PortugalCenter for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, PortugalFaculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Coimbra, PortugalFaculty of Medicine, Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), University of Coimbra, Coimbra, PortugalFaculty of Medicine, General Pathology Institute, University of Coimbra, Coimbra, PortugalCenter for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, PortugalObstetrics Department, Coimbra University Hospital Center, Coimbra, PortugalFaculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Coimbra, PortugalFaculty of Medicine, Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), University of Coimbra, Coimbra, PortugalCenter for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, PortugalFaculty of Medicine (FMUC), Institute of Immunology, University of Coimbra, Coimbra, PortugalCenter for Neuroscience and Cell Biology (CNC), Laboratory of Immunology and Oncology, University of Coimbra, Coimbra, PortugalFaculty of Medicine (FMUC), Institute of Immunology, University of Coimbra, Coimbra, PortugalFaculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Coimbra, PortugalFaculty of Medicine, Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), University of Coimbra, Coimbra, PortugalFaculty of Medicine, General Pathology Institute, University of Coimbra, Coimbra, PortugalCenter for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, PortugalInnate lymphoid cells (ILCs) are a new set of cells considered to be a part of the innate immune system. ILCs are classified into five subsets (according to their transcription factors and cytokine profile) as natural killer cells (NK cells), group 1 ILCs, group 2 ILCs, group 3 ILCs, and lymphoid tissue inducers (LTi). Functionally, these cells resemble the T helper population but lack the expression of recombinant genes, which is essential for the formation of T cell receptors. In this work, the authors address the distinction between peripheral and decidual NK cells, highlighting their diversity in ILC biology and its relevance to human pregnancy. ILCs are effector cells that are important in promoting immunity, inflammation, and tissue repair. Recent studies have directed their attention to ILC actions in pregnancy. Dysregulation or expansion of pro-inflammatory ILC populations as well as abnormal tolerogenic responses may directly interfere with pregnancy, ultimately resulting in pregnancy loss or adverse outcomes. In this review, we characterize these cells, considering recent findings and addressing knowledge gaps in perinatal medicine in the context of ILC biology. Moreover, we discuss the relevance of these cells not only to the process of immune tolerance, but also in disease.https://www.frontiersin.org/articles/10.3389/fimmu.2020.551707/fullinnate lymphoid cellsinnate immune responseinflammationpregnancypreterm birth |
| spellingShingle | João Mendes João Mendes João Mendes João Mendes Ana Luísa Areia Ana Luísa Areia Ana Luísa Areia Ana Luísa Areia Ana Luísa Areia Paulo Rodrigues-Santos Paulo Rodrigues-Santos Paulo Rodrigues-Santos Paulo Rodrigues-Santos Paulo Rodrigues-Santos Manuel Santos-Rosa Anabela Mota-Pinto Anabela Mota-Pinto Anabela Mota-Pinto Anabela Mota-Pinto Innate Lymphoid Cells in Human Pregnancy Frontiers in Immunology innate lymphoid cells innate immune response inflammation pregnancy preterm birth |
| title | Innate Lymphoid Cells in Human Pregnancy |
| title_full | Innate Lymphoid Cells in Human Pregnancy |
| title_fullStr | Innate Lymphoid Cells in Human Pregnancy |
| title_full_unstemmed | Innate Lymphoid Cells in Human Pregnancy |
| title_short | Innate Lymphoid Cells in Human Pregnancy |
| title_sort | innate lymphoid cells in human pregnancy |
| topic | innate lymphoid cells innate immune response inflammation pregnancy preterm birth |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.551707/full |
| work_keys_str_mv | AT joaomendes innatelymphoidcellsinhumanpregnancy AT joaomendes innatelymphoidcellsinhumanpregnancy AT joaomendes innatelymphoidcellsinhumanpregnancy AT joaomendes innatelymphoidcellsinhumanpregnancy AT analuisaareia innatelymphoidcellsinhumanpregnancy AT analuisaareia innatelymphoidcellsinhumanpregnancy AT analuisaareia innatelymphoidcellsinhumanpregnancy AT analuisaareia innatelymphoidcellsinhumanpregnancy AT analuisaareia innatelymphoidcellsinhumanpregnancy AT paulorodriguessantos innatelymphoidcellsinhumanpregnancy AT paulorodriguessantos innatelymphoidcellsinhumanpregnancy AT paulorodriguessantos innatelymphoidcellsinhumanpregnancy AT paulorodriguessantos innatelymphoidcellsinhumanpregnancy AT paulorodriguessantos innatelymphoidcellsinhumanpregnancy AT manuelsantosrosa innatelymphoidcellsinhumanpregnancy AT anabelamotapinto innatelymphoidcellsinhumanpregnancy AT anabelamotapinto innatelymphoidcellsinhumanpregnancy AT anabelamotapinto innatelymphoidcellsinhumanpregnancy AT anabelamotapinto innatelymphoidcellsinhumanpregnancy |