The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan
Aim. To perform the analysis of the association of transcription factor 7-like 2 (TCF7L2) gene rs7903146 polymorphism with type 2 diabetes mellitus (T2DM) among Tatars of Bashkortostan. Materials and methods. In this study, 169 patients with T2DM and 286 controls without clinical symptoms and labora...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2016-05-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/7111 |
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| author | Diana S. Avzaletdinova Leisan F. Sharipova Olga V. Kochetova Tatyana Vyacheslavovna Morugova Vera V. Erdman Regina S. Somova Olga E. Mustafina |
| author_facet | Diana S. Avzaletdinova Leisan F. Sharipova Olga V. Kochetova Tatyana Vyacheslavovna Morugova Vera V. Erdman Regina S. Somova Olga E. Mustafina |
| author_sort | Diana S. Avzaletdinova |
| collection | DOAJ |
| description | Aim. To perform the analysis of the association of transcription factor 7-like 2 (TCF7L2) gene rs7903146 polymorphism with type 2 diabetes mellitus (T2DM) among Tatars of Bashkortostan. Materials and methods. In this study, 169 patients with T2DM and 286 controls without clinical symptoms and laboratory signs of diabetes and without diabetes relatives were examined. Amplification of the DNA fragments was performed using real-time polymerase chain reaction (PCR) and TaqMan technique. Results. Genotype CT and allele T ratios were higher in the T2DM group than in controls (46. 7% vs. 36. 4%, p = 0. 030; 41. 7% vs. 30. 8%, p = 0. 001 respectively). There was a positive association between allele T and T2DM (OR = 1. 61), and allele C had a protective effect (OR = 0. 62, p = 0,001). Carriers of the ТТ genotype had later onset of T2DM (mean = 59. 5 years old) compared with carriers of the CT and CC genotypes (56. 1 years old, p = 0. 044). Basal C-peptide concentration, lipid levels and body mass index were not associated with TCF7L2 rs7903146 polymorphism. Conclusion. TCF7L2 rs7903146 polymorphism is associated with T2DM among Tatars of Bashkortostan. |
| first_indexed | 2024-03-08T15:20:46Z |
| format | Article |
| id | doaj.art-e9104020fa524b25b4954c3a76e07d82 |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:02:48Z |
| publishDate | 2016-05-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-e9104020fa524b25b4954c3a76e07d822024-03-20T11:48:00ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782016-05-0119211912410.14341/DM2004138-457308The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of BashkortostanDiana S. Avzaletdinova0Leisan F. Sharipova1Olga V. Kochetova2Tatyana Vyacheslavovna Morugova3Vera V. Erdman4Regina S. Somova5Olga E. Mustafina6Bashkir State Medical University, UfaBashkir State Medical University, UfaInstitute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences, UfaBashkir State Medical University, UfaInstitute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences, UfaInstitute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences, UfaInstitute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences, UfaAim. To perform the analysis of the association of transcription factor 7-like 2 (TCF7L2) gene rs7903146 polymorphism with type 2 diabetes mellitus (T2DM) among Tatars of Bashkortostan. Materials and methods. In this study, 169 patients with T2DM and 286 controls without clinical symptoms and laboratory signs of diabetes and without diabetes relatives were examined. Amplification of the DNA fragments was performed using real-time polymerase chain reaction (PCR) and TaqMan technique. Results. Genotype CT and allele T ratios were higher in the T2DM group than in controls (46. 7% vs. 36. 4%, p = 0. 030; 41. 7% vs. 30. 8%, p = 0. 001 respectively). There was a positive association between allele T and T2DM (OR = 1. 61), and allele C had a protective effect (OR = 0. 62, p = 0,001). Carriers of the ТТ genotype had later onset of T2DM (mean = 59. 5 years old) compared with carriers of the CT and CC genotypes (56. 1 years old, p = 0. 044). Basal C-peptide concentration, lipid levels and body mass index were not associated with TCF7L2 rs7903146 polymorphism. Conclusion. TCF7L2 rs7903146 polymorphism is associated with T2DM among Tatars of Bashkortostan.https://www.dia-endojournals.ru/jour/article/view/7111type 2 diabetes mellitustcf7l2molecular genetics |
| spellingShingle | Diana S. Avzaletdinova Leisan F. Sharipova Olga V. Kochetova Tatyana Vyacheslavovna Morugova Vera V. Erdman Regina S. Somova Olga E. Mustafina The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan Сахарный диабет type 2 diabetes mellitus tcf7l2 molecular genetics |
| title | The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan |
| title_full | The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan |
| title_fullStr | The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan |
| title_full_unstemmed | The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan |
| title_short | The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan |
| title_sort | association of tcf7l2 rs7903146 polymorphism with type 2 diabetes mellitus among tatars of bashkortostan |
| topic | type 2 diabetes mellitus tcf7l2 molecular genetics |
| url | https://www.dia-endojournals.ru/jour/article/view/7111 |
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