LAPTM4B allele *2 is a marker of poor prognosis for gallbladder carcinoma.
BACKGROUND: Lysosomal protein transmembrane 4 beta (LAPTM4B) is a novel cancer-related gene which has two alleles designated LAPTM4B*1 and LAPTM4B*2. In this study we investigated the correlation of LAPTM4B genotype with prognosis and clinicopathologic features in patients who had undergone curative...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3440336?pdf=render |
| _version_ | 1818043092669825024 |
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| author | Guojun Zhai Kaowen Yan Xiaoxu Ji Wenrui Xu Jiuling Yang Fuxia Xiong Jing Su Michael A McNutt Hua Yang |
| author_facet | Guojun Zhai Kaowen Yan Xiaoxu Ji Wenrui Xu Jiuling Yang Fuxia Xiong Jing Su Michael A McNutt Hua Yang |
| author_sort | Guojun Zhai |
| collection | DOAJ |
| description | BACKGROUND: Lysosomal protein transmembrane 4 beta (LAPTM4B) is a novel cancer-related gene which has two alleles designated LAPTM4B*1 and LAPTM4B*2. In this study we investigated the correlation of LAPTM4B genotype with prognosis and clinicopathologic features in patients who had undergone curative resection for gallbladder carcinoma (GBC). METHODOLOGY/PRINCIPAL FINDINGS: PCR assay was performed to determine the LAPTM4B genotype in 85 patients. The correlation of LAPTM4B genotype with clinicopathologic parameters was assessed with the Chi-squared test. Differences in patient survival were determined by the Kaplan-Meier method. Multivariate analysis of prognostic factors was carried out with Cox regression analysis. Patients with LAPTM4B *2 had both significantly shorter overall survival (OS) and shorter disease-free survival (DFS) (both P<0.001). Multivariate analysis showed that LAPTM4B genotype is a prognostic factor for OS and DFS (both P<0.001). CONCLUSIONS/SIGNIFICANCE: LAPTM4B allele *2 is a risk factor associated with poor prognosis in patients with resected GBC, and LAPTM4B status may be therefore be useful preoperatively as an adjunct in evaluation of the operability of GBC. |
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| format | Article |
| id | doaj.art-e910baa3ac5f4b469debf96b1748c5f9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T08:56:43Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e910baa3ac5f4b469debf96b1748c5f92022-12-22T01:55:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0179e4529010.1371/journal.pone.0045290LAPTM4B allele *2 is a marker of poor prognosis for gallbladder carcinoma.Guojun ZhaiKaowen YanXiaoxu JiWenrui XuJiuling YangFuxia XiongJing SuMichael A McNuttHua YangBACKGROUND: Lysosomal protein transmembrane 4 beta (LAPTM4B) is a novel cancer-related gene which has two alleles designated LAPTM4B*1 and LAPTM4B*2. In this study we investigated the correlation of LAPTM4B genotype with prognosis and clinicopathologic features in patients who had undergone curative resection for gallbladder carcinoma (GBC). METHODOLOGY/PRINCIPAL FINDINGS: PCR assay was performed to determine the LAPTM4B genotype in 85 patients. The correlation of LAPTM4B genotype with clinicopathologic parameters was assessed with the Chi-squared test. Differences in patient survival were determined by the Kaplan-Meier method. Multivariate analysis of prognostic factors was carried out with Cox regression analysis. Patients with LAPTM4B *2 had both significantly shorter overall survival (OS) and shorter disease-free survival (DFS) (both P<0.001). Multivariate analysis showed that LAPTM4B genotype is a prognostic factor for OS and DFS (both P<0.001). CONCLUSIONS/SIGNIFICANCE: LAPTM4B allele *2 is a risk factor associated with poor prognosis in patients with resected GBC, and LAPTM4B status may be therefore be useful preoperatively as an adjunct in evaluation of the operability of GBC.http://europepmc.org/articles/PMC3440336?pdf=render |
| spellingShingle | Guojun Zhai Kaowen Yan Xiaoxu Ji Wenrui Xu Jiuling Yang Fuxia Xiong Jing Su Michael A McNutt Hua Yang LAPTM4B allele *2 is a marker of poor prognosis for gallbladder carcinoma. PLoS ONE |
| title | LAPTM4B allele *2 is a marker of poor prognosis for gallbladder carcinoma. |
| title_full | LAPTM4B allele *2 is a marker of poor prognosis for gallbladder carcinoma. |
| title_fullStr | LAPTM4B allele *2 is a marker of poor prognosis for gallbladder carcinoma. |
| title_full_unstemmed | LAPTM4B allele *2 is a marker of poor prognosis for gallbladder carcinoma. |
| title_short | LAPTM4B allele *2 is a marker of poor prognosis for gallbladder carcinoma. |
| title_sort | laptm4b allele 2 is a marker of poor prognosis for gallbladder carcinoma |
| url | http://europepmc.org/articles/PMC3440336?pdf=render |
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