Association of vitamin D with triglyceride-glucose index and cardiometabolic risk factors in subclinical hypothyroidism
Background: The present study aimed to explore the association of vitamin D with triglyceride-glucose (TyG) index and cardiometabolic risk factors in subclinical hypothyroidism (SCH). Methods: We recruited 75 individuals diagnosed with SCH and 75 healthy controls of both genders aged 20 to 65 years....
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Human Nutrition & Metabolism |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666149723000439 |
| _version_ | 1797435758722678784 |
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| author | Roshan Kumar Mahat Gautam Panda Bibhu Prasad Nayak Suchismita Panda |
| author_facet | Roshan Kumar Mahat Gautam Panda Bibhu Prasad Nayak Suchismita Panda |
| author_sort | Roshan Kumar Mahat |
| collection | DOAJ |
| description | Background: The present study aimed to explore the association of vitamin D with triglyceride-glucose (TyG) index and cardiometabolic risk factors in subclinical hypothyroidism (SCH). Methods: We recruited 75 individuals diagnosed with SCH and 75 healthy controls of both genders aged 20 to 65 years. Triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and 25-hydroxyvitamin D [25(OH)D] were measured using chemiluminescent immunoassay. Fasting plasma glucose and lipid profile were analyzed by standard methods. The TyG index was calculated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)]/2. Results: There were significant decreases in 25(OH)D levels and changes in cardiometabolic risk factors among individuals with SCH compared to healthy controls. Additionally, there was a significant increase in the TyG index among the SCH group. Correlation and regression analysis revealed that 25(OH)D was significantly and negatively associated with TyG index, diastolic blood pressure (DBP), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C). However, it was positively associated with high-density lipoprotein cholesterol (HDL-C). Conclusion: Present study shows that SCH patients have lower vitamin D levels and higher TyG index, increasing cardiovascular disease risk. Screening and managing vitamin D deficiency is crucial in these subjects. In addition, TyG index could be used as an indicator for identifying vitamin D deficiency. |
| first_indexed | 2024-03-09T10:52:53Z |
| format | Article |
| id | doaj.art-e910e4de7fcb44caa332112f60a0ec7e |
| institution | Directory Open Access Journal |
| issn | 2666-1497 |
| language | English |
| last_indexed | 2024-03-09T10:52:53Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Nutrition & Metabolism |
| spelling | doaj.art-e910e4de7fcb44caa332112f60a0ec7e2023-12-01T05:03:06ZengElsevierHuman Nutrition & Metabolism2666-14972023-12-0134200226Association of vitamin D with triglyceride-glucose index and cardiometabolic risk factors in subclinical hypothyroidismRoshan Kumar Mahat0Gautam Panda1Bibhu Prasad Nayak2Suchismita Panda3Department of Biochemistry, Dharanidhar Medical College and Hospital, Keonjhar, IndiaConsultant Ophthalmologist, Kalinga Superspeciality Hospital, Bhubaneswar, IndiaDepartment of Pediatrics, Dharanidhar Medical College and Hospital, Keonjhar, IndiaDepartment of Biochemistry, Dharanidhar Medical College and Hospital, Keonjhar, India; Corresponding author. Department of Biochemistry, Dharanidhar Medical College and Hospital, Keonjhar, 758002, India.Background: The present study aimed to explore the association of vitamin D with triglyceride-glucose (TyG) index and cardiometabolic risk factors in subclinical hypothyroidism (SCH). Methods: We recruited 75 individuals diagnosed with SCH and 75 healthy controls of both genders aged 20 to 65 years. Triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and 25-hydroxyvitamin D [25(OH)D] were measured using chemiluminescent immunoassay. Fasting plasma glucose and lipid profile were analyzed by standard methods. The TyG index was calculated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)]/2. Results: There were significant decreases in 25(OH)D levels and changes in cardiometabolic risk factors among individuals with SCH compared to healthy controls. Additionally, there was a significant increase in the TyG index among the SCH group. Correlation and regression analysis revealed that 25(OH)D was significantly and negatively associated with TyG index, diastolic blood pressure (DBP), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C). However, it was positively associated with high-density lipoprotein cholesterol (HDL-C). Conclusion: Present study shows that SCH patients have lower vitamin D levels and higher TyG index, increasing cardiovascular disease risk. Screening and managing vitamin D deficiency is crucial in these subjects. In addition, TyG index could be used as an indicator for identifying vitamin D deficiency.http://www.sciencedirect.com/science/article/pii/S2666149723000439Subclinical hypothyroidismVitamin DTyG indexLipid profile |
| spellingShingle | Roshan Kumar Mahat Gautam Panda Bibhu Prasad Nayak Suchismita Panda Association of vitamin D with triglyceride-glucose index and cardiometabolic risk factors in subclinical hypothyroidism Human Nutrition & Metabolism Subclinical hypothyroidism Vitamin D TyG index Lipid profile |
| title | Association of vitamin D with triglyceride-glucose index and cardiometabolic risk factors in subclinical hypothyroidism |
| title_full | Association of vitamin D with triglyceride-glucose index and cardiometabolic risk factors in subclinical hypothyroidism |
| title_fullStr | Association of vitamin D with triglyceride-glucose index and cardiometabolic risk factors in subclinical hypothyroidism |
| title_full_unstemmed | Association of vitamin D with triglyceride-glucose index and cardiometabolic risk factors in subclinical hypothyroidism |
| title_short | Association of vitamin D with triglyceride-glucose index and cardiometabolic risk factors in subclinical hypothyroidism |
| title_sort | association of vitamin d with triglyceride glucose index and cardiometabolic risk factors in subclinical hypothyroidism |
| topic | Subclinical hypothyroidism Vitamin D TyG index Lipid profile |
| url | http://www.sciencedirect.com/science/article/pii/S2666149723000439 |
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