The Role of RNA Editing in Cancer Development and Metabolic Disorders
Numerous human diseases arise from alterations of genetic information, most notably DNA mutations. Thought to be merely the intermediate between DNA and protein, changes in RNA sequence were an afterthought until the discovery of RNA editing 30 years ago. RNA editing alters RNA sequence without alte...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2018.00762/full |
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| author | Che-Pei Kung Che-Pei Kung Leonard B. Maggi Leonard B. Maggi Jason D. Weber Jason D. Weber Jason D. Weber |
| author_facet | Che-Pei Kung Che-Pei Kung Leonard B. Maggi Leonard B. Maggi Jason D. Weber Jason D. Weber Jason D. Weber |
| author_sort | Che-Pei Kung |
| collection | DOAJ |
| description | Numerous human diseases arise from alterations of genetic information, most notably DNA mutations. Thought to be merely the intermediate between DNA and protein, changes in RNA sequence were an afterthought until the discovery of RNA editing 30 years ago. RNA editing alters RNA sequence without altering the sequence or integrity of genomic DNA. The most common RNA editing events are A-to-I changes mediated by adenosine deaminase acting on RNA (ADAR), and C-to-U editing mediated by apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1). Both A-to-I and C-to-U editing were first identified in the context of embryonic development and physiological homeostasis. The role of RNA editing in human disease has only recently started to be understood. In this review, the impact of RNA editing on the development of cancer and metabolic disorders will be examined. Distinctive functions of each RNA editase that regulate either A-to-I or C-to-U editing will be highlighted in addition to pointing out important regulatory mechanisms governing these processes. The potential of developing novel therapeutic approaches through intervention of RNA editing will be explored. As the role of RNA editing in human disease is elucidated, the clinical utility of RNA editing targeted therapies will be needed. This review aims to serve as a bridge of information between past findings and future directions of RNA editing in the context of cancer and metabolic disease. |
| first_indexed | 2024-12-13T00:56:24Z |
| format | Article |
| id | doaj.art-e91137ce2f7747c3875ec60fa2250a89 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-13T00:56:24Z |
| publishDate | 2018-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-e91137ce2f7747c3875ec60fa2250a892022-12-22T00:04:48ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-12-01910.3389/fendo.2018.00762428241The Role of RNA Editing in Cancer Development and Metabolic DisordersChe-Pei Kung0Che-Pei Kung1Leonard B. Maggi2Leonard B. Maggi3Jason D. Weber4Jason D. Weber5Jason D. Weber6ICCE Institute, Washington University School of Medicine, Saint Louis, MO, United StatesDivision of Molecular Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, United StatesICCE Institute, Washington University School of Medicine, Saint Louis, MO, United StatesDivision of Molecular Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, United StatesICCE Institute, Washington University School of Medicine, Saint Louis, MO, United StatesDivision of Molecular Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, United StatesSiteman Cancer Center, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, United StatesNumerous human diseases arise from alterations of genetic information, most notably DNA mutations. Thought to be merely the intermediate between DNA and protein, changes in RNA sequence were an afterthought until the discovery of RNA editing 30 years ago. RNA editing alters RNA sequence without altering the sequence or integrity of genomic DNA. The most common RNA editing events are A-to-I changes mediated by adenosine deaminase acting on RNA (ADAR), and C-to-U editing mediated by apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1). Both A-to-I and C-to-U editing were first identified in the context of embryonic development and physiological homeostasis. The role of RNA editing in human disease has only recently started to be understood. In this review, the impact of RNA editing on the development of cancer and metabolic disorders will be examined. Distinctive functions of each RNA editase that regulate either A-to-I or C-to-U editing will be highlighted in addition to pointing out important regulatory mechanisms governing these processes. The potential of developing novel therapeutic approaches through intervention of RNA editing will be explored. As the role of RNA editing in human disease is elucidated, the clinical utility of RNA editing targeted therapies will be needed. This review aims to serve as a bridge of information between past findings and future directions of RNA editing in the context of cancer and metabolic disease.https://www.frontiersin.org/article/10.3389/fendo.2018.00762/fullRNA editingADARAPOBEC1cancermetabolic disease |
| spellingShingle | Che-Pei Kung Che-Pei Kung Leonard B. Maggi Leonard B. Maggi Jason D. Weber Jason D. Weber Jason D. Weber The Role of RNA Editing in Cancer Development and Metabolic Disorders Frontiers in Endocrinology RNA editing ADAR APOBEC1 cancer metabolic disease |
| title | The Role of RNA Editing in Cancer Development and Metabolic Disorders |
| title_full | The Role of RNA Editing in Cancer Development and Metabolic Disorders |
| title_fullStr | The Role of RNA Editing in Cancer Development and Metabolic Disorders |
| title_full_unstemmed | The Role of RNA Editing in Cancer Development and Metabolic Disorders |
| title_short | The Role of RNA Editing in Cancer Development and Metabolic Disorders |
| title_sort | role of rna editing in cancer development and metabolic disorders |
| topic | RNA editing ADAR APOBEC1 cancer metabolic disease |
| url | https://www.frontiersin.org/article/10.3389/fendo.2018.00762/full |
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