Water-Soluble <i>closo</i>-Docecaborate-Containing Pteroyl Derivatives Targeting Folate Receptor-Positive Tumors for Boron Neutron Capture Therapy

Water-Soluble <i>closo</i>-Docecaborate-Containing Pteroyl Derivatives Targeting Folate Receptor-Positive Tumors for Boron Neutron Capture Therapy

Water-soluble pteroyl-<i>closo</i>-dodecaborate conjugates (PBCs 1–4), were developed as folate receptor (FRα) targeting boron carriers for boron neutron capture therapy (BNCT). PBCs 1–4 had adequately low cytotoxicity with IC<sub>50</sub> values in the range of 1~3 mM toward...

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Bibliographic Details
Main Authors:	Fumiko Nakagawa, Hidehisa Kawashima, Taiki Morita, Hiroyuki Nakamura
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Series:	Cells
Subjects:	boron neutron capture therapy folate FRα <i>closo</i>-dodecaborate water-soluble
Online Access:	https://www.mdpi.com/2073-4409/9/7/1615

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