Human Protoparvoviruses
Next-generation sequencing and metagenomics have revolutionized the discovery of novel viruses. In recent years, three novel protoparvoviruses have been discovered in fecal samples of humans: bufavirus (BuV) in 2012, tusavirus (TuV) in 2014, and cutavirus (CuV) in 2016. BuV has since been studied th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/9/11/354 |
| _version_ | 1811259253499887616 |
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| author | Elina Väisänen Yu Fu Klaus Hedman Maria Söderlund-Venermo |
| author_facet | Elina Väisänen Yu Fu Klaus Hedman Maria Söderlund-Venermo |
| author_sort | Elina Väisänen |
| collection | DOAJ |
| description | Next-generation sequencing and metagenomics have revolutionized the discovery of novel viruses. In recent years, three novel protoparvoviruses have been discovered in fecal samples of humans: bufavirus (BuV) in 2012, tusavirus (TuV) in 2014, and cutavirus (CuV) in 2016. BuV has since been studied the most, disclosing three genotypes that also represent serotypes. Besides one nasal sample, BuV DNA has been found exclusively in diarrheal feces, but not in non-diarrheal feces, suggesting a causal relationship. According to both geno- and seroprevalences, BuV appears to be the most common of the three novel protoparvoviruses, whereas TuV DNA has been found in only a single fecal sample, with antibody detection being equally rare. Moreover, the TuV sequence is closer to those of non-human protoparvoviruses, and so the evidence of TuV being a human virus is thus far insufficient. Interestingly, besides in feces, CuV has also been detected in skin biopsies of patients with cutaneous T-cell lymphoma and a patient with melanoma, while all other skin samples have tested PCR negative. Even if preliminary disease associations exist, the full etiological roles of these viruses in human disease are yet to be resolved. |
| first_indexed | 2024-04-12T18:27:41Z |
| format | Article |
| id | doaj.art-e911fc1871a043f8a9e85dba8dec8a08 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-12T18:27:41Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-e911fc1871a043f8a9e85dba8dec8a082022-12-22T03:21:10ZengMDPI AGViruses1999-49152017-11-0191135410.3390/v9110354v9110354Human ProtoparvovirusesElina Väisänen0Yu Fu1Klaus Hedman2Maria Söderlund-Venermo3Department of Virology, University of Helsinki, Helsinki 00290, FinlandDepartment of Virology, University of Helsinki, Helsinki 00290, FinlandDepartment of Virology, University of Helsinki, Helsinki 00290, FinlandDepartment of Virology, University of Helsinki, Helsinki 00290, FinlandNext-generation sequencing and metagenomics have revolutionized the discovery of novel viruses. In recent years, three novel protoparvoviruses have been discovered in fecal samples of humans: bufavirus (BuV) in 2012, tusavirus (TuV) in 2014, and cutavirus (CuV) in 2016. BuV has since been studied the most, disclosing three genotypes that also represent serotypes. Besides one nasal sample, BuV DNA has been found exclusively in diarrheal feces, but not in non-diarrheal feces, suggesting a causal relationship. According to both geno- and seroprevalences, BuV appears to be the most common of the three novel protoparvoviruses, whereas TuV DNA has been found in only a single fecal sample, with antibody detection being equally rare. Moreover, the TuV sequence is closer to those of non-human protoparvoviruses, and so the evidence of TuV being a human virus is thus far insufficient. Interestingly, besides in feces, CuV has also been detected in skin biopsies of patients with cutaneous T-cell lymphoma and a patient with melanoma, while all other skin samples have tested PCR negative. Even if preliminary disease associations exist, the full etiological roles of these viruses in human disease are yet to be resolved.https://www.mdpi.com/1999-4915/9/11/354human protoparvovirusbufavirustusaviruscutavirusdiscoveryepidemiologygastroenteritiscutaneous T-cell lymphomaemerging viruses |
| spellingShingle | Elina Väisänen Yu Fu Klaus Hedman Maria Söderlund-Venermo Human Protoparvoviruses Viruses human protoparvovirus bufavirus tusavirus cutavirus discovery epidemiology gastroenteritis cutaneous T-cell lymphoma emerging viruses |
| title | Human Protoparvoviruses |
| title_full | Human Protoparvoviruses |
| title_fullStr | Human Protoparvoviruses |
| title_full_unstemmed | Human Protoparvoviruses |
| title_short | Human Protoparvoviruses |
| title_sort | human protoparvoviruses |
| topic | human protoparvovirus bufavirus tusavirus cutavirus discovery epidemiology gastroenteritis cutaneous T-cell lymphoma emerging viruses |
| url | https://www.mdpi.com/1999-4915/9/11/354 |
| work_keys_str_mv | AT elinavaisanen humanprotoparvoviruses AT yufu humanprotoparvoviruses AT klaushedman humanprotoparvoviruses AT mariasoderlundvenermo humanprotoparvoviruses |