Activation of Both TLR and NOD Signaling Confers Host Innate Immunity-Mediated Protection Against Microbial Infection

Activation of Both TLR and NOD Signaling Confers Host Innate Immunity-Mediated Protection Against Microbial Infection

The detection of microbial pathogens relies on the recognition of highly conserved microbial structures by the membrane sensor Toll-like receptors (TLRs) and cytosolic sensor NOD-like receptors (NLRs). Upon detection, these sensors trigger innate immune responses to eradicate the invaded microbial p...

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Bibliographic Details
Main Authors: Huiting Zhou, Andrew P. Coveney, Ming Wu, Jie Huang, Siobhan Blankson, He Zhao, D. Peter O'Leary, Zhenjiang Bai, Yiping Li, H. Paul Redmond, Jiang Huai Wang, Jian Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
TLR signaling
NOD signaling
inflammatory response
antimicrobial activity
NF-κB pathway
phagosome maturation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03082/full

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