Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins
The establishment of neuronal circuits requires neurons to develop and maintain appropriate connections with cellular partners in and out the central nervous system. These phenomena include elaboration of dendritic arborization and formation of synaptic contacts, initially made in excess. Subsequent...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/11/6111 |
| _version_ | 1797531197879877632 |
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| author | Greta Limoni |
| author_facet | Greta Limoni |
| author_sort | Greta Limoni |
| collection | DOAJ |
| description | The establishment of neuronal circuits requires neurons to develop and maintain appropriate connections with cellular partners in and out the central nervous system. These phenomena include elaboration of dendritic arborization and formation of synaptic contacts, initially made in excess. Subsequently, refinement occurs, and pruning takes places both at axonal and synaptic level, defining a homeostatic balance maintained throughout the lifespan. All these events require genetic regulations which happens cell-autonomously and are strongly influenced by environmental factors. This review aims to discuss the involvement of guidance cues from the Semaphorin family. |
| first_indexed | 2024-03-10T10:40:30Z |
| format | Article |
| id | doaj.art-e9146bcb2f684df79abc1ea97fdeb51c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:40:30Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e9146bcb2f684df79abc1ea97fdeb51c2023-11-21T22:59:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012211611110.3390/ijms22116111Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of SemaphorinsGreta Limoni0Department of Basic Neuroscience, University of Geneva Medical Center, Rue Michel-Servet 1, 1206 Geneva, SwitzerlandThe establishment of neuronal circuits requires neurons to develop and maintain appropriate connections with cellular partners in and out the central nervous system. These phenomena include elaboration of dendritic arborization and formation of synaptic contacts, initially made in excess. Subsequently, refinement occurs, and pruning takes places both at axonal and synaptic level, defining a homeostatic balance maintained throughout the lifespan. All these events require genetic regulations which happens cell-autonomously and are strongly influenced by environmental factors. This review aims to discuss the involvement of guidance cues from the Semaphorin family.https://www.mdpi.com/1422-0067/22/11/6111amyotrophic lateral sclerosisaxon pruningdendritogenesisneurodegenerationneuromuscular junctionperineuronal net |
| spellingShingle | Greta Limoni Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins International Journal of Molecular Sciences amyotrophic lateral sclerosis axon pruning dendritogenesis neurodegeneration neuromuscular junction perineuronal net |
| title | Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins |
| title_full | Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins |
| title_fullStr | Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins |
| title_full_unstemmed | Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins |
| title_short | Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins |
| title_sort | modelling and refining neuronal circuits with guidance cues involvement of semaphorins |
| topic | amyotrophic lateral sclerosis axon pruning dendritogenesis neurodegeneration neuromuscular junction perineuronal net |
| url | https://www.mdpi.com/1422-0067/22/11/6111 |
| work_keys_str_mv | AT gretalimoni modellingandrefiningneuronalcircuitswithguidancecuesinvolvementofsemaphorins |