Lyme borreliosis diagnosis: state of the art of improvements and innovations
Abstract With almost 700 000 estimated cases each year in the United States and Europe, Lyme borreliosis (LB), also called Lyme disease, is the most common tick-borne illness in the world. Transmitted by ticks of the genus Ixodes and caused by bacteria Borrelia burgdorferi sensu lato, LB occurs with...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Microbiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12866-023-02935-5 |
| _version_ | 1797752872513830912 |
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| author | Mickaël Guérin Marc Shawky Ahed Zedan Stéphane Octave Bérangère Avalle Irene Maffucci Séverine Padiolleau-Lefèvre |
| author_facet | Mickaël Guérin Marc Shawky Ahed Zedan Stéphane Octave Bérangère Avalle Irene Maffucci Séverine Padiolleau-Lefèvre |
| author_sort | Mickaël Guérin |
| collection | DOAJ |
| description | Abstract With almost 700 000 estimated cases each year in the United States and Europe, Lyme borreliosis (LB), also called Lyme disease, is the most common tick-borne illness in the world. Transmitted by ticks of the genus Ixodes and caused by bacteria Borrelia burgdorferi sensu lato, LB occurs with various symptoms, such as erythema migrans, which is characteristic, whereas others involve blurred clinical features such as fatigue, headaches, arthralgia, and myalgia. The diagnosis of Lyme borreliosis, based on a standard two-tiered serology, is the subject of many debates and controversies, since it relies on an indirect approach which suffers from a low sensitivity depending on the stage of the disease. Above all, early detection of the disease raises some issues. Inappropriate diagnosis of Lyme borreliosis leads to therapeutic wandering, inducing potential chronic infection with a strong antibody response that fails to clear the infection. Early and proper detection of Lyme disease is essential to propose an adequate treatment to patients and avoid the persistence of the pathogen. This review presents the available tests, with an emphasis on the improvements of the current diagnosis, the innovative methods and ideas which, ultimately, will allow more precise detection of LB. |
| first_indexed | 2024-03-12T17:09:46Z |
| format | Article |
| id | doaj.art-e916ecb269064d07a8fa9f01a540c8e9 |
| institution | Directory Open Access Journal |
| issn | 1471-2180 |
| language | English |
| last_indexed | 2024-03-12T17:09:46Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Microbiology |
| spelling | doaj.art-e916ecb269064d07a8fa9f01a540c8e92023-08-06T11:08:35ZengBMCBMC Microbiology1471-21802023-08-0123112010.1186/s12866-023-02935-5Lyme borreliosis diagnosis: state of the art of improvements and innovationsMickaël Guérin0Marc Shawky1Ahed Zedan2Stéphane Octave3Bérangère Avalle4Irene Maffucci5Séverine Padiolleau-Lefèvre6Unité de Génie Enzymatique Et Cellulaire (GEC), CNRS UMR 7025, Université de Technologie de CompiègneConnaissance Organisation Et Systèmes TECHniques (COSTECH), EA 2223, Université de Technologie de CompiègnePolyclinique Saint CômeUnité de Génie Enzymatique Et Cellulaire (GEC), CNRS UMR 7025, Université de Technologie de CompiègneUnité de Génie Enzymatique Et Cellulaire (GEC), CNRS UMR 7025, Université de Technologie de CompiègneUnité de Génie Enzymatique Et Cellulaire (GEC), CNRS UMR 7025, Université de Technologie de CompiègneUnité de Génie Enzymatique Et Cellulaire (GEC), CNRS UMR 7025, Université de Technologie de CompiègneAbstract With almost 700 000 estimated cases each year in the United States and Europe, Lyme borreliosis (LB), also called Lyme disease, is the most common tick-borne illness in the world. Transmitted by ticks of the genus Ixodes and caused by bacteria Borrelia burgdorferi sensu lato, LB occurs with various symptoms, such as erythema migrans, which is characteristic, whereas others involve blurred clinical features such as fatigue, headaches, arthralgia, and myalgia. The diagnosis of Lyme borreliosis, based on a standard two-tiered serology, is the subject of many debates and controversies, since it relies on an indirect approach which suffers from a low sensitivity depending on the stage of the disease. Above all, early detection of the disease raises some issues. Inappropriate diagnosis of Lyme borreliosis leads to therapeutic wandering, inducing potential chronic infection with a strong antibody response that fails to clear the infection. Early and proper detection of Lyme disease is essential to propose an adequate treatment to patients and avoid the persistence of the pathogen. This review presents the available tests, with an emphasis on the improvements of the current diagnosis, the innovative methods and ideas which, ultimately, will allow more precise detection of LB.https://doi.org/10.1186/s12866-023-02935-5Lyme diseaseTickDiagnosticCulturePCRSerology detection, Direct and indirect methods |
| spellingShingle | Mickaël Guérin Marc Shawky Ahed Zedan Stéphane Octave Bérangère Avalle Irene Maffucci Séverine Padiolleau-Lefèvre Lyme borreliosis diagnosis: state of the art of improvements and innovations BMC Microbiology Lyme disease Tick Diagnostic Culture PCR Serology detection, Direct and indirect methods |
| title | Lyme borreliosis diagnosis: state of the art of improvements and innovations |
| title_full | Lyme borreliosis diagnosis: state of the art of improvements and innovations |
| title_fullStr | Lyme borreliosis diagnosis: state of the art of improvements and innovations |
| title_full_unstemmed | Lyme borreliosis diagnosis: state of the art of improvements and innovations |
| title_short | Lyme borreliosis diagnosis: state of the art of improvements and innovations |
| title_sort | lyme borreliosis diagnosis state of the art of improvements and innovations |
| topic | Lyme disease Tick Diagnostic Culture PCR Serology detection, Direct and indirect methods |
| url | https://doi.org/10.1186/s12866-023-02935-5 |
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