The Effect of Sneezing on the Reduction of Infarct Volume and the Improvement of Neurological Deficits in Male Rats
Background: Sneezing transiently elevates cerebral blood flow. We speculated that induced sneezing, following embolism would restore arterial flow, thereby diminishing infarct volume and improving neurological deficits. Materials and Methods: Male rats were subjected to middle cerebral artery occlus...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Advanced Biomedical Research |
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| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2018;volume=7;issue=1;spage=142;epage=142;aulast=Vanaie |
| _version_ | 1818671513404964864 |
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| author | Mahdi Vanaie Majid Valiyan Boroujeni Hamed Motavallipour Abarghuie Ali Asghar Pourshanazari Hossein Rezazadeh |
| author_facet | Mahdi Vanaie Majid Valiyan Boroujeni Hamed Motavallipour Abarghuie Ali Asghar Pourshanazari Hossein Rezazadeh |
| author_sort | Mahdi Vanaie |
| collection | DOAJ |
| description | Background: Sneezing transiently elevates cerebral blood flow. We speculated that induced sneezing, following embolism would restore arterial flow, thereby diminishing infarct volume and improving neurological deficits. Materials and Methods: Male rats were subjected to middle cerebral artery occlusion (MCAO) using prepared clots (embolization) and randomized into four equal groups as follows: (1) pre-MCAO-induced sneezing (PRMIS), (2) post-MCAO-induced sneezing (POMIS), and (3) pre- and POMIS (PRPOMIS) and the control group (eight rats per group). In the treatment groups, rats' sneezing episodes were induced before MCAO in PRMIS group or before regaining consciousness from surgical anesthesia in other treatment groups by cutting their whiskers during their anesthesia and subsequently inserted them into the rats' nostrils. Infarct volume was evaluated by 2, 3, 5-triphenyl tetrazolium chloride staining, and neurological deficits and brain edema were assessed by Bederson scale deficit scores 24-h post-MCAO. Results: The infarct volume and brain edema reduced and neurological deficits improved in the induced sneezing groups as compared with the MCAO control group. Compared to the control group, the highest improvements in the infarct volume and neurological deficits were seen in the PRPOMIS group, and POMIS group showed the most significant differences concerning the results of both ischemic and nonischemic brain edema. The highest protective effect was observed in the central region of the MCA territory. Conclusions: The reduction in ischemia-induced brain injury, brain edema, and neurological deficits by sneezing suggest that brief episodes of acute hypertension after stroke can increase blood flow to the ischemic area and improve recovery. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2277-9175 |
| language | English |
| last_indexed | 2024-12-17T07:25:12Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-e917dbaea35448cb8dfa96fca0fcc4622022-12-21T21:58:39ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752018-01-017114214210.4103/abr.abr_119_18The Effect of Sneezing on the Reduction of Infarct Volume and the Improvement of Neurological Deficits in Male RatsMahdi VanaieMajid Valiyan BoroujeniHamed Motavallipour AbarghuieAli Asghar PourshanazariHossein RezazadehBackground: Sneezing transiently elevates cerebral blood flow. We speculated that induced sneezing, following embolism would restore arterial flow, thereby diminishing infarct volume and improving neurological deficits. Materials and Methods: Male rats were subjected to middle cerebral artery occlusion (MCAO) using prepared clots (embolization) and randomized into four equal groups as follows: (1) pre-MCAO-induced sneezing (PRMIS), (2) post-MCAO-induced sneezing (POMIS), and (3) pre- and POMIS (PRPOMIS) and the control group (eight rats per group). In the treatment groups, rats' sneezing episodes were induced before MCAO in PRMIS group or before regaining consciousness from surgical anesthesia in other treatment groups by cutting their whiskers during their anesthesia and subsequently inserted them into the rats' nostrils. Infarct volume was evaluated by 2, 3, 5-triphenyl tetrazolium chloride staining, and neurological deficits and brain edema were assessed by Bederson scale deficit scores 24-h post-MCAO. Results: The infarct volume and brain edema reduced and neurological deficits improved in the induced sneezing groups as compared with the MCAO control group. Compared to the control group, the highest improvements in the infarct volume and neurological deficits were seen in the PRPOMIS group, and POMIS group showed the most significant differences concerning the results of both ischemic and nonischemic brain edema. The highest protective effect was observed in the central region of the MCA territory. Conclusions: The reduction in ischemia-induced brain injury, brain edema, and neurological deficits by sneezing suggest that brief episodes of acute hypertension after stroke can increase blood flow to the ischemic area and improve recovery.http://www.advbiores.net/article.asp?issn=2277-9175;year=2018;volume=7;issue=1;spage=142;epage=142;aulast=VanaieAnimalsbrain edemainfarctionmiddle cerebral arteryrats |
| spellingShingle | Mahdi Vanaie Majid Valiyan Boroujeni Hamed Motavallipour Abarghuie Ali Asghar Pourshanazari Hossein Rezazadeh The Effect of Sneezing on the Reduction of Infarct Volume and the Improvement of Neurological Deficits in Male Rats Advanced Biomedical Research Animals brain edema infarction middle cerebral artery rats |
| title | The Effect of Sneezing on the Reduction of Infarct Volume and the Improvement of Neurological Deficits in Male Rats |
| title_full | The Effect of Sneezing on the Reduction of Infarct Volume and the Improvement of Neurological Deficits in Male Rats |
| title_fullStr | The Effect of Sneezing on the Reduction of Infarct Volume and the Improvement of Neurological Deficits in Male Rats |
| title_full_unstemmed | The Effect of Sneezing on the Reduction of Infarct Volume and the Improvement of Neurological Deficits in Male Rats |
| title_short | The Effect of Sneezing on the Reduction of Infarct Volume and the Improvement of Neurological Deficits in Male Rats |
| title_sort | effect of sneezing on the reduction of infarct volume and the improvement of neurological deficits in male rats |
| topic | Animals brain edema infarction middle cerebral artery rats |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2018;volume=7;issue=1;spage=142;epage=142;aulast=Vanaie |
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