mRNA Delivery: Challenges and Advances through Polymeric Soft Nanoparticles
Single-stranded messenger ribonucleic acid (mRNA) plays a pivotal role in transferring genetic information, and tremendous effort has been devoted over the years to utilize its transcription efficacy in therapeutic interventions for a variety of diseases with high morbidity and mortality. Lipid nano...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/3/1739 |
| _version_ | 1797318703321186304 |
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| author | Samaneh Yousefi Adlsadabad John W. Hanrahan Ashok Kakkar |
| author_facet | Samaneh Yousefi Adlsadabad John W. Hanrahan Ashok Kakkar |
| author_sort | Samaneh Yousefi Adlsadabad |
| collection | DOAJ |
| description | Single-stranded messenger ribonucleic acid (mRNA) plays a pivotal role in transferring genetic information, and tremendous effort has been devoted over the years to utilize its transcription efficacy in therapeutic interventions for a variety of diseases with high morbidity and mortality. Lipid nanocarriers have been extensively investigated for mRNA delivery and enabled the rapid and successful development of mRNA vaccines against SARS-CoV-2. Some constraints of lipid nanocarriers have encouraged the development of alternative delivery systems, such as polymer-based soft nanoparticles, which offer a modular gene delivery platform. Such macromolecule-based nanocarriers can be synthetically articulated for tailored parameters including mRNA protection, loading efficacy, and targeted release. In this review, we highlight recent advances in the development of polymeric architectures for mRNA delivery, their limitations, and the challenges that still exist, with the aim of expediting further research and the clinical translation of such formulations. |
| first_indexed | 2024-03-08T03:56:08Z |
| format | Article |
| id | doaj.art-e917f46381f94f5eb8d3056df1a83473 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T03:56:08Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e917f46381f94f5eb8d3056df1a834732024-02-09T15:14:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01253173910.3390/ijms25031739mRNA Delivery: Challenges and Advances through Polymeric Soft NanoparticlesSamaneh Yousefi Adlsadabad0John W. Hanrahan1Ashok Kakkar2Department of Chemistry, McGill University, 801 Sherbrooke St West, Montreal, QC H3A 0B8, CanadaDepartment of Physiology, McGill University, 3655 Promenade Sir-William-Osler, Montreal, QC H3G 1Y6, CanadaDepartment of Chemistry, McGill University, 801 Sherbrooke St West, Montreal, QC H3A 0B8, CanadaSingle-stranded messenger ribonucleic acid (mRNA) plays a pivotal role in transferring genetic information, and tremendous effort has been devoted over the years to utilize its transcription efficacy in therapeutic interventions for a variety of diseases with high morbidity and mortality. Lipid nanocarriers have been extensively investigated for mRNA delivery and enabled the rapid and successful development of mRNA vaccines against SARS-CoV-2. Some constraints of lipid nanocarriers have encouraged the development of alternative delivery systems, such as polymer-based soft nanoparticles, which offer a modular gene delivery platform. Such macromolecule-based nanocarriers can be synthetically articulated for tailored parameters including mRNA protection, loading efficacy, and targeted release. In this review, we highlight recent advances in the development of polymeric architectures for mRNA delivery, their limitations, and the challenges that still exist, with the aim of expediting further research and the clinical translation of such formulations.https://www.mdpi.com/1422-0067/25/3/1739mRNA therapeuticscationic and non-cationic polymerspolymer lipid hybrid systems |
| spellingShingle | Samaneh Yousefi Adlsadabad John W. Hanrahan Ashok Kakkar mRNA Delivery: Challenges and Advances through Polymeric Soft Nanoparticles International Journal of Molecular Sciences mRNA therapeutics cationic and non-cationic polymers polymer lipid hybrid systems |
| title | mRNA Delivery: Challenges and Advances through Polymeric Soft Nanoparticles |
| title_full | mRNA Delivery: Challenges and Advances through Polymeric Soft Nanoparticles |
| title_fullStr | mRNA Delivery: Challenges and Advances through Polymeric Soft Nanoparticles |
| title_full_unstemmed | mRNA Delivery: Challenges and Advances through Polymeric Soft Nanoparticles |
| title_short | mRNA Delivery: Challenges and Advances through Polymeric Soft Nanoparticles |
| title_sort | mrna delivery challenges and advances through polymeric soft nanoparticles |
| topic | mRNA therapeutics cationic and non-cationic polymers polymer lipid hybrid systems |
| url | https://www.mdpi.com/1422-0067/25/3/1739 |
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