Metastatic breast tumors downregulate miR-145 regulating the hypoxia-induced vasculogenic mimicry

Metastatic breast tumors downregulate miR-145 regulating the hypoxia-induced vasculogenic mimicry

Tumor cells grow in three-dimensional (3D) channels-like structures denoted as vasculogenic mimicry (VM), which provides a route for nutrients and oxygen acquisition. VM is activated by hypoxia and associated with metastasis and poor prognosis. MetastamiRs are microRNAs regulating metastasis, howeve...

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Main Authors: Estefania Contreras-Sanzón, Ángeles Carlos-Reyes, Mónica Sierra-Martínez, Gustavo Acosta-Altamirano, Cesar Luna-Rivero, David Núñez-Corona, Alejandra Paola García-Hernández, Eloisa Ibarra-Sierra, Horacio Vidrio-Morgado, María Elizbeth Alvarez-Sánchez, Laurence A. Marchat, César López-Camarillo
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Translational Oncology
Subjects:
breast cancer
vasculogenic mimicry
metastasis
miR-145
therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323000669

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